Could probiotics be the missing ingredient for gestational diabetes?

NCT ID NCT07645001

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study will test whether adding a probiotic supplement to standard diabetes medications (metformin or insulin) improves blood sugar control and reduces inflammation in pregnant women with gestational diabetes. Two hundred women diagnosed between 18-26 weeks of pregnancy will be split into four groups: metformin alone, insulin alone, metformin plus probiotics, or insulin plus probiotics. The goal is to see if the probiotic combination leads to better outcomes for both mother and baby.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
multistrain probiotic (HI flora sachet) plus metformin or insulin
What this could lead to
If it works, this could point toward a simple, safe way to improve blood sugar control and reduce complications for mothers and babies with gestational diabetes.
What could go wrong
This is an early-stage trial with 200 participants, so results may not apply to all women. Probiotics may not provide additional benefit over standard treatment.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Pakistan Railway Hospital

    RECRUITING

    Rawalpindi, Punjab Province, 46000, Pakistan

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