Could a simple antibiotic during pregnancy save thousands of newborns?
NCT ID NCT06723392
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether treating asymptomatic bacteriuria (a bladder infection with no symptoms) in pregnant women can reduce the number of preterm births, stillbirths, and underweight babies. Over 1,100 pregnant women in seven low- and middle-income countries will receive either a 7-day course of the antibiotic nitrofurantoin or a placebo. The goal is to see if this simple, low-cost intervention improves newborn survival and health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nitrofurantoin (an antibiotic)
What this could lead to
If it works, this could show that treating hidden bladder infections during pregnancy reduces the risk of preterm birth, stillbirth, and underweight babies in low-resource settings.
What could go wrong
This is a large phase 3 trial, but previous studies on this topic have had mixed results. The antibiotic may not improve outcomes, and side effects or antibiotic resistance are possible risks.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aga Khan University
NOT_YET_RECRUITINGKarachi, Pakistan, Pakistan
Contact Email: •••••@•••••
Contact
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Icddr,B
RECRUITINGDhaka, Bangladesh, Bangladesh
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
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Institue for Nutrition of Central America and Panama (INCAP)
NOT_YET_RECRUITINGGuatemala City, Departamento de Guatemala, Guatemala
Contact Email: •••••@•••••
Contact
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KLE Academy of Higher Education and Research
RECRUITINGBelagavi, Karnataka, India
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kinshasa School of Public Health
NOT_YET_RECRUITINGKinshasa, DRC, Democratic Republic of the Congo
Contact Email: •••••@•••••
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Lata Medical Research Foundation
NOT_YET_RECRUITINGNagpur, Maharashtra, India
Contact Email: •••••@•••••
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University Teaching Hospital
NOT_YET_RECRUITINGLusaka, Zambia, Zambia
Contact Email: •••••@•••••
Contact