Could a simple antibiotic during pregnancy save thousands of newborns?

NCT ID NCT06723392

Recruiting now Disease control Sponsor: NICHD Global Network for Women's and Children's Health Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether treating asymptomatic bacteriuria (a bladder infection with no symptoms) in pregnant women can reduce the number of preterm births, stillbirths, and underweight babies. Over 1,100 pregnant women in seven low- and middle-income countries will receive either a 7-day course of the antibiotic nitrofurantoin or a placebo. The goal is to see if this simple, low-cost intervention improves newborn survival and health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nitrofurantoin (an antibiotic)
What this could lead to: If it works, this could show that treating hidden bladder infections during pregnancy reduces the risk of preterm birth, stillbirth, and underweight babies in low-resource settings.
What could go wrong: This is a large phase 3 trial, but previous studies on this topic have had mixed results. The antibiotic may not improve outcomes, and side effects or antibiotic resistance are possible risks.

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Conditions

The condition(s) this trial relates to.

bacteriuria fetal growth restriction pregnancy disorder with abortive outcome Premature Birth Stillbirth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BACTERIURIA (ASYMPTOMATIC) IN PREGNANCY PRETERM BIRTH SMALL FOR GESTATIONAL AGE (SGA) STILLBIRTH

Contacts and locations

Locations

Aga Khan University
NOT_YET_RECRUITING

Karachi, Pakistan, Pakistan
Icddr,B
RECRUITING

Dhaka, Bangladesh, Bangladesh
Institue for Nutrition of Central America and Panama (INCAP)
NOT_YET_RECRUITING

Guatemala City, Departamento de Guatemala, Guatemala
KLE Academy of Higher Education and Research
RECRUITING

Belagavi, Karnataka, India
Kinshasa School of Public Health
NOT_YET_RECRUITING

Kinshasa, DRC, Democratic Republic of the Congo
Lata Medical Research Foundation
NOT_YET_RECRUITING

Nagpur, Maharashtra, India
University Teaching Hospital
NOT_YET_RECRUITING

Lusaka, Zambia, Zambia

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