Can hepatitis c treatment start safely in pregnancy? new study aims to find out

NCT ID NCT06367465

Recruiting now Disease control Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether starting hepatitis C treatment during pregnancy is feasible and acceptable for women who have used drugs. Fifty pregnant adults with hepatitis C will take glecaprevir-pibrentasvir daily for 56 days. Researchers will track how well participants stick to the medication and how satisfied they are with the process, aiming to improve care for this vulnerable group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Glecaprevir-pibrentasvir (an oral hepatitis C medication)
What this could lead to: If successful, this could show that treating hepatitis C during pregnancy is practical and well-tolerated, potentially reducing mother-to-child transmission and improving long-term health for both.
What could go wrong: This is a small, early feasibility study with only 50 participants, so results may not apply to all pregnant women. Adherence may be challenging, and the study does not yet prove long-term safety or cure.

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Conditions

The condition(s) this trial relates to.

hepatitis C virus infection pregnancy disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATITIS C PREGNANCY COMPLICATIONS

Contacts and locations

Locations

Barnes Jewish Hospital
RECRUITING

St Louis, Missouri, 63110, United States
Washington Univeristy
RECRUITING

St Louis, Missouri, 63110, United States

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