PREGNANCY COMPLICATIONS

This study tests whether providing money specifically for healthy foods helps pregnant women avoid gaining too much weight. About 1,440 women will either get standard nutrition advice or that plus up to $3,000 for healthy groceries. Researchers will compare weight gain between th…

This study tests if leg exercise (like pedaling) is better than arm exercise for controlling blood sugar, weight, and stress in pregnant women with gestational diabetes. 108 women in their second trimester will exercise three times a week for eight weeks. The goal is to find a sa…

This study looks at whether starting hepatitis C treatment during pregnancy is feasible and acceptable for women who have used drugs. Fifty pregnant adults with hepatitis C will take glecaprevir-pibrentasvir daily for 56 days. Researchers will track how well participants stick to…

This study tests whether taking low-dose aspirin for six months after childbirth can help blood vessels heal and lower blood pressure in women who had preeclampsia. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple treatment can redu…

This study tests whether adding certolizumab (Cimzia) to standard care (heparin and aspirin) can prevent fetal death or early delivery in pregnant women with antiphospholipid syndrome (APS) and lupus anticoagulant. About 55 women will receive the drug early in pregnancy and be co…

This study tests whether an automated insulin delivery system (CamAPS FX) can help women with type 1 diabetes maintain better blood sugar control before and during pregnancy, compared to their usual insulin routine. The trial will enroll 305 women aged 18-45 who are either planni…

This study tests whether giving pregnant people at risk of preterm birth half the usual dose of a steroid (Celestone) works as well as the full dose to prevent serious health problems in their babies. About 3,250 participants will receive either one or two doses after an initial …

This study tests whether wearing a continuous glucose monitor that shows real-time blood sugar levels on a smartphone app, plus joining a group chat with other pregnant women, helps keep glucose levels healthy during pregnancy. About 70 pregnant women at risk for gestational diab…

This study tests a new method called U-CaVIT, which uses a balloon placed in the uterus to prevent severe bleeding after a C-section in women at high risk. About 70 participants will either get standard care or standard care plus the balloon. The goal is to see if the balloon red…

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…

This study compares two pain relief methods—propofol sedation and spinal analgesia with bupivacaine—during a procedure to turn breech babies (external cephalic version). The goal is to see which method leads to more successful turns and fewer complications. 270 pregnant women wit…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This pilot study is testing a specially designed exercise program for high-risk pregnant women who are hospitalized on bed rest. The exercises are adapted to be done while lying in bed, focusing on strength and resistance. Researchers want to see if this program can improve physi…

This study explores the real-life experiences of people who had Lyme disease during or before pregnancy and are now raising children. Participants fill out surveys about their health, mental well-being, and child development, then take part in an interview to share their personal…

This study follows 40 pregnant women with Lyme disease to see how the infection might affect their baby's development. Researchers will monitor pregnancies and check infant growth, thinking, and motor skills from birth to 18 months. The goal is to learn if Lyme exposure in the wo…

This study is testing two new ultrasound techniques to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will scan 60 pregnant women every three weeks using a …

This study tests an iPad app called Periviable GOALS that helps parents facing a very early preterm birth (22-25 weeks) understand their options and clarify their values. The app includes videos and outcome information designed for people with varying literacy levels. Researchers…

This study looks at how pregnant women sleep, focusing on the positions they spend the most time in and how often they snore. About 500 women who are at least 28 weeks pregnant will use a sleep monitor at home. The goal is to learn more about sleep patterns during pregnancy and s…

This study examines how cells in the placenta manage waste and self-destruction in women with pregnancy complications like pre-eclampsia and intrauterine growth restriction. Researchers will take blood and urine samples from 50 pregnant women throughout their pregnancy and at del…

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study looks at how the natural microbes and chemical profiles in couples' bodies relate to IVF outcomes. Researchers will collect samples from 1000 couples and track whether they have a baby, miscarriage, or other pregnancy results. The goal is to find patterns that might he…

This study looks at whether routine blood sugar tests (like fasting glucose and HbA1c) can predict gestational diabetes in pregnant women who have had bariatric surgery and cannot tolerate the standard sugary drink test. Researchers will follow 84 women throughout pregnancy to se…

This 10-year observational registry will follow up to 10 women with Fabry disease who received pegunigalsidase alfa (Elfabrio) around the time of pregnancy or while breastfeeding, along with their infants. Researchers will track pregnancy outcomes, birth defects, and infant healt…

This study follows 500 mother-child pairs where the mother has a severe hemophilia A gene. It aims to understand bleeding risks during pregnancy and childbirth for mothers, and how children develop antibodies to factor VIII treatment. By observing families over time, researchers …

This study uses ultrasound to measure muscle, fat, and fluid changes in 121 critically ill pregnant or gynecological patients in the ICU. The goal is to see if these body composition changes are linked to serious outcomes like death, need for a breathing machine, or longer hospit…

This study looks at pregnancy outcomes in 50 women who had at least one pregnancy before being diagnosed with lupus. Researchers will collect data from medical records and interviews to see how often pregnancy complications occurred before the lupus diagnosis. The goal is to bett…

This study follows 6,000 pregnant women in rural Pakistan to understand how high temperatures impact pregnancy and birth outcomes. Researchers will track heat exposure, collect blood and urine samples, and monitor mothers and babies for up to a year after birth. The goal is to id…

This study looks at whether women with gestational diabetes (GDM) experience muscle loss, known as sarcopenia, and how this might affect pregnancy outcomes and thinking skills. Researchers will test 200 pregnant women using muscle strength and function tests, along with standard …

This long-term study follows 24,000 mothers and their children born at Boston Medical Center to understand how early-life exposures—like pregnancy complications and birth outcomes—affect health later in life. Researchers will track conditions such as asthma, obesity, allergies, a…

This study looks at how pregnant women at risk for preeclampsia process aspirin and how that relates to signs of metabolic problems. Researchers will measure aspirin byproducts in blood and urine, along with other health markers, in 50 women. The goal is to better understand why …