PREGNANCY COMPLICATIONS

This study tests if wearing a continuous glucose monitor (CGM) that shows blood sugar on a phone app, plus joining a group chat with other pregnant participants, helps keep blood sugar healthy during pregnancy. The goal is to prevent health problems for both mother and baby. The …

This study compares an automated insulin delivery system (CamAPS FX) to usual insulin methods in 305 women with type 1 diabetes who are planning pregnancy or are in early pregnancy. The goal is to see if the automated system helps keep blood sugar in a healthy range and improves …

This study looks at whether giving pregnant people at risk of preterm birth a single, lower dose of steroids works as well as the usual two-dose treatment. The goal is to reduce serious health problems in premature babies, like breathing issues or brain bleeding. About 3,250 part…

This study looks at whether starting hepatitis C treatment during pregnancy works well for women who have used drugs. About 50 pregnant women will take the medication glecaprevir-pibrentasvir and be followed for a year. Researchers will check how well they stick to the treatment …

This study tests whether a buprenorphine patch can reduce withdrawal symptoms in pregnant women with opioid use disorder when starting treatment. About 40 participants will receive either the patch or standard care during the required withdrawal period before taking buprenorphine…

This study tests whether taking low-dose aspirin for 6 months after childbirth can help women who had preeclampsia recover their blood vessel health and lower their blood pressure. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple tr…

This study tests whether adding a specially trained doula to standard care helps women who had high blood pressure during pregnancy get their blood pressure under control after giving birth. About 454 women will be randomly assigned to either usual blood pressure monitoring at ho…

This study tests whether providing extra money specifically for healthy groceries during pregnancy can help women avoid gaining too much weight. About 1,440 pregnant women will either receive standard nutrition advice and food assistance referrals, or the same plus up to $3,000 t…

This study tests whether adding the drug certolizumab to standard treatment (blood thinners and low-dose aspirin) can prevent pregnancy complications like miscarriage or early delivery in pregnant women with antiphospholipid syndrome (APS) and lupus anticoagulant. All 55 particip…

This study tests a special balloon device (U-CaVIT) placed inside the uterus during C-section to prevent severe bleeding in women at high risk. About 70 women will be randomly assigned to receive either standard care or standard care plus the balloon. The goal is to see if the ba…

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can better prevent preeclampsia in pregnant women at high risk. Preeclampsia is a dangerous condition involving high blood pressure and organ damage. The trial will enroll 100…

This pilot study tests a simple exercise program designed for high-risk pregnant women who are on bed rest in the hospital. The program includes resistance and strength training done while lying in bed. Researchers want to see if it improves physical health, emotional well-being,…

This study tests whether propofol sedation or spinal analgesia works better for external cephalic version, a procedure to turn a breech baby head-down before birth. About 270 pregnant women with a breech baby will be randomly assigned to one of the two pain relief methods. The go…

This study uses bedside ultrasound to track muscle loss, fat changes, and fluid buildup in critically ill pregnant and gynecological patients. Researchers will see if these body changes are linked to serious outcomes like death, need for a breathing machine, or longer ICU stays. …

This study looks at whether women with gestational diabetes (diabetes during pregnancy) also have sarcopenia, a condition of muscle loss and weakness. Researchers will check 200 pregnant women for sarcopenia and follow their pregnancy outcomes and thinking abilities. The goal is …

This study looks at whether common blood sugar tests (like fasting glucose and HbA1c) can replace the sugary drink test for diagnosing gestational diabetes in pregnant women who have had bariatric surgery. Many of these women cannot tolerate the standard drink due to side effects…

This study is a worldwide registry that will follow about 10 women with Fabry disease who take the medication pegunigalsidase alfa during pregnancy or while breastfeeding. Researchers will track the health of both mothers and their babies for up to one year after birth. The goal …

This study looks back at the pregnancy history of 50 women who were later diagnosed with lupus. The goal is to find out how often pregnancy problems like miscarriage or preterm birth happen before the lupus diagnosis. By understanding these early signs, doctors may be able to spo…

This study looks at how things that happen early in life—like pregnancy complications or birth outcomes—can affect health later for both mothers and children. Researchers are following 24,000 mothers and their babies born at Boston Medical Center. The goal is to understand links …

This study is testing two new ultrasound techniques to see if they can better detect fetal growth restriction (FGR), a condition where a baby is smaller than expected. Researchers will compare these scans in 60 pregnant women, some with healthy pregnancies and some with FGR. The …

This study follows pregnant women with a severe hemophilia A gene and their babies after birth. The goal is to learn why some mothers have heavy bleeding after delivery and why some children develop antibodies that make hemophilia treatment less effective. By observing 500 mother…

This study looks at how cells in the placenta die or recycle themselves in pregnant women with conditions like preeclampsia or poor fetal growth. Researchers will compare these cell processes in 50 women to better understand why these complications happen. The goal is to find new…

This study looks at how the body processes aspirin in pregnant women who are at risk for preeclampsia, a serious condition involving high blood pressure. Researchers will measure markers of metabolic health, like fatty acids and salicylate levels, in 50 participants. The goal is …

This study tests a decision support tool called Periviable GOALS for parents facing the threat of giving birth extremely early (between 22 and 25 weeks of pregnancy). The tool provides clear information about outcomes and helps parents clarify their values. About 300 parents will…

This study looks at how the bacteria and natural chemicals in couples' bodies might influence the success of IVF treatment. Researchers will collect samples from 1000 couples to see if these factors are linked to pregnancy, miscarriage, or live birth. The goal is to better unders…

This study aims to understand how exposure to high temperatures during pregnancy affects the health of mothers and their babies. Researchers will follow 6,000 pregnant women in rural Pakistan, where extreme heat is common, by monitoring their environment and health throughout pre…