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Scientists dive into amniotic fluid to unlock preterm gut mysteries

NCT ID NCT07152106

Recruiting now Knowledge-focused Sponsor: Maxima Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study collects amniotic fluid from 275 pregnant women delivering at various stages, including extremely preterm. Researchers will analyze the fluid's microbes and chemicals, and link them to the baby's gut bacteria and health outcomes like necrotizing enterocolitis (NEC) and sepsis. The goal is to better understand how amniotic fluid influences gut development and infection risk in preterm infants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could help identify high-risk preterm infants earlier and guide future treatments to prevent serious gut infections.
What could go wrong
This is an observational study, not a treatment trial. It will not directly improve health outcomes and may not lead to any new therapies.

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Conditions

The condition(s) this trial relates to.

chorioamnionitis fetal growth restriction necrotizing enterocolitis neonatal sepsis perinatal necrotizing enterocolitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHORIOAMNIONITIS CHORIOAMNIONITIS AFFECTING FETUS OR NEWBORN FETAL GROWTH RESTRICTION (FGR) NECROTIZING ENTEROCOLITIS OF NEWBORN NEONATAL SEPSIS, EARLY-ONSET NEONATAL SEPSIS, LATE-ONSET PREMATURITY COMPLICATIONS PRETERM BIRTH COMPLICATION

Contacts and locations

Locations

  • Amsterdam UMC

    RECRUITING

    Amsterdam, Netherlands

  • Máxima Medical Center

    RECRUITING

    Veldhoven, Netherlands

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