Necrotizing enterocolitis

This early-phase study tests whether an oral supplement called L-Citrulline is safe for preterm babies born at or before 30 weeks who have lung problems (BPD) or a serious gut condition (NEC). The goal is to see if raising low levels of a natural substance in the blood can reduce…

This study tests a procedure called mucous fistula refeeding in 120 infants who have a temporary bowel opening (enterostomy). The idea is to take the baby's own stool and put it back into the lower bowel to help it get ready to work again. The goal is to see if this helps babies …

This study tests a new drug called ST266 in premature infants with necrotizing enterocolitis (NEC), a severe gut infection. The trial will include 36 babies and aims to see if the drug is safe and tolerable at two different doses. Researchers will also look for early signs that i…

This study tests a device called the Eclipse XL1 that is placed inside the body to slowly stretch and lengthen the remaining small intestine in people with short bowel syndrome. The goal is to improve nutrition and reduce the need for intravenous feeding. The study will enroll 40…

This study tests whether early physiotherapy, taught to parents, can improve movement and development in babies at risk for problems like cerebral palsy. Fifty infants from the NICU will be randomly assigned to get either the special program or standard care. Researchers will mea…

This study aims to see if an artificial intelligence tool can predict necrotizing enterocolitis (NEC) — a severe and often fatal gut infection — in premature babies by analyzing their stool samples. Researchers will collect stool from 1,000 premature babies across several hospita…

This large international trial tests whether temporarily stopping milk feeds around the time of a blood transfusion can prevent necrotizing enterocolitis (NEC), a severe gut infection, in very premature babies (born before 30 weeks). Over 4,000 infants in Canada and the UK will b…

This study tests whether tiny particles called extracellular vesicles, naturally found in human milk, can prevent necrotizing enterocolitis (NEC) in very premature infants. Twenty babies born before 32 weeks will receive these particles as a supplement. Researchers will monitor s…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study looks at very preterm babies to understand how feeding during blood transfusions affects blood flow and oxygen levels in their gut. Researchers will use non-invasive monitors to measure these changes in 270 infants. The goal is to find safer care practices that could l…

This UK study follows 90 families of very premature babies (born before 30 weeks) for one year after hospital discharge. It measures how caring for a baby with or without necrotising enterocolitis (NEC)—a serious bowel disease—affects the family's finances, emotions, and quality …

This study looks at how the intestines develop in premature and full-term babies up to 2 years old. Researchers will collect tissue, blood, and stool samples from infants already having intestinal surgery or scopes. The goal is to better understand normal development and diseases…

This study looks at tiny particles called extracellular vesicles in the umbilical cord blood of extremely premature babies (born before 28 weeks). Researchers want to see if these particles can help predict serious problems like brain bleeding, lung injury, or death. The goal is …

This study tests whether giving extra arginine (a nutrient) to preterm and full-term infants after major bowel surgery or a serious gut infection (necrotising enterocolitis) can improve their immune function. Researchers will measure changes in gene activity related to infection-…

This study is looking at whether small differences in certain genes make very low birth-weight babies more likely to develop chronic lung disease and other complications of prematurity. Researchers will compare the genes of 1,100 infants who develop these conditions with those wh…

This study is collecting and analyzing immune cells from the umbilical cord blood of premature and full-term newborns. Researchers want to understand how these cells respond to certain inflammatory signals, which may help explain why some premature babies develop necrotizing ente…

This study collects amniotic fluid from 275 pregnant women delivering at various stages, including extremely preterm. Researchers will analyze the fluid's microbes and chemicals, and link them to the baby's gut bacteria and health outcomes like necrotizing enterocolitis (NEC) and…