Necrotizing enterocolitis
MONDO:0005313Necrotizing enterocolitis (NEC) is a devastating disease that affects mostly the intestine of premature infants. The wall of the intestine is invaded by bacteria, which cause local infection and inflammation that can ultimately destroy the wall of the bowel (intestine). Such bowel wall destruction can lead to perforation of the intestine and spillage of stool into the infant's abdomen, which can result in an overwhelming infection and death.
Also known as: NEC, necrotizing enterocolitis, necrotizing enterocolitis in fetus or newborn, necrotizing enterocolitis in foetus or newborn
49 clinical trials for this condition and its sub-types.
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Could a simple saline enema save tiny preemies from deadly gut disease?
Disease control TerminatedThis study tested whether giving extremely preterm babies (born before 27 weeks) a gentle saline enema twice a day could help them reach full feeding sooner and prevent necrotizing enterocolitis (NEC), a severe gut infection. The trial planned to include 200 infants but was termi…
Phase: NA • Sponsor: Uppsala County Council, Sweden • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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New Light-Based test aims to catch deadly newborn gut disease early
Diagnosis TerminatedThis study looked at whether measuring oxygen levels in the brain and gut using a light-based device (NIRS) could help doctors diagnose necrotizing enterocolitis (NEC) earlier in newborns with symptoms like bloody stool or a swollen belly. The study planned to include 45 newborns…
Phase: NA • Sponsor: University Hospital, Montpellier • Aim: Diagnosis
Last updated Jun 27, 2026 14:00 UTC