Necrotizing enterocolitis
MONDO:0005313Necrotizing enterocolitis (NEC) is a devastating disease that affects mostly the intestine of premature infants. The wall of the intestine is invaded by bacteria, which cause local infection and inflammation that can ultimately destroy the wall of the bowel (intestine). Such bowel wall destruction can lead to perforation of the intestine and spillage of stool into the infant's abdomen, which can result in an overwhelming infection and death.
Also known as: NEC, necrotizing enterocolitis, necrotizing enterocolitis in fetus or newborn, necrotizing enterocolitis in foetus or newborn
51 clinical trials for this condition and its sub-types.
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Broader categories
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Could a steroid shot help tiny preemies survive shock?
Disease control OngoingThis study tests whether giving the steroid hydrocortisone early, right when shock is diagnosed, helps very small preterm babies (under 1500 grams) recover faster. Researchers will compare babies who get standard shock treatment plus hydrocortisone to those who get standard treat…
Phase 4 • Sponsor: Coordinación de Investigación en Salud, Mexico • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Sugar compound aimed at saving tiny guts: trial pulled before start
Disease control CancelledThis study was designed to test whether a supplement called chondroitin sulfate is safe for newborns with necrotizing enterocolitis (NEC), a severe gut infection. The plan was to give the supplement to very low birth weight babies for two days and compare their outcomes to those …
Phase 1 • Sponsor: Indiana University • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Probiotics may shield preterm infants from fatal gut infection
Prevention OngoingThis study tests whether giving probiotics to preterm babies (born before 35 weeks) can prevent necrotizing enterocolitis (NEC), a severe gut infection. About 196 infants will receive either probiotics or a placebo within 24 hours of birth. The main goal is to see if fewer babies…
Sponsor: Hayatabad Medical Complex • Aim: Prevention
Last updated Aug 20, 2026 00:00 UTC
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New study aims to predict deadly gut infection in preemies before symptoms appear
Knowledge-focused OngoingThis study looks for early signs of necrotizing enterocolitis (NEC), a severe gut infection in premature babies. Researchers will use non-invasive measures and blood markers to identify at-risk infants before symptoms start. The goal is to eventually prevent the disease from prog…
Sponsor: Nationwide Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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Can poop predict preemie health? new study investigates
Knowledge-focused OngoingThis study follows 300 premature babies born before 33 weeks to see if the bacteria in their stool can predict life-threatening conditions like necrotizing enterocolitis, a severe gut infection. Researchers will also analyze the babies' DNA from saliva and look at small molecules…
Sponsor: University of California, Davis • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Premature Babies' gut disease leaves lasting nutrition scars, new study shows
Knowledge-focused By invitation onlyThis study follows 200 premature babies who had a serious gut infection called necrotizing enterocolitis (NEC) to see how it affects their nutrition and growth by age 5. Researchers will check for problems like food allergies, poor growth, feeding difficulties, and other digestiv…
Sponsor: Central Hospital, Nancy, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Could a blood pressure cuff save tiny lives? new trial explores simple treatment for deadly newborn gut disease
Knowledge-focused OngoingThis study looks at a procedure called remote ischemic conditioning (RIC) for newborns with necrotizing enterocolitis (NEC), a serious gut disease. RIC involves briefly inflating a blood pressure cuff on the baby's arm to protect the gut from damage. The main goal is to see if a …
Phase 2 • Sponsor: The Hospital for Sick Children • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC