Could a steroid shot help tiny preemies survive shock?

NCT ID NCT07248761

Ongoing Disease control Sponsor: Coordinación de Investigación en Salud, Mexico Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving the steroid hydrocortisone early, right when shock is diagnosed, helps very small preterm babies (under 1500 grams) recover faster. Researchers will compare babies who get standard shock treatment plus hydrocortisone to those who get standard treatment alone. The goal is to see if early hydrocortisone resolves shock within 72 hours and reduces death in the first week.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hydrocortisone (a steroid hormone) given intravenously
What this could lead to: If it works, this could lead to a standard early treatment for shock in very small preterm babies, potentially saving lives in the first week.
What could go wrong: This is a small, single-country Phase 4 trial (76 babies). The benefit may be modest, and steroids carry risks like infection or high blood sugar in fragile newborns.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome hyperglycemia intestinal perforation necrotizing enterocolitis neonatal sepsis patent ductus arteriosus perinatal asphyxia Pulmonary Atelectasis Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASPHYXIA PERINATAL DISTRESS RESPIRATORY SYNDROME HYPERGLYCAEMIA (NON DIABETIC) INTESTINAL PERFORATION NEC - NECROTIZING ENTEROCOLITIS NEONATAL SEPSIS, EARLY-ONSET NEONATAL SEPSIS, LATE-ONSET PATENT DUCTUS ARTERIOSUS IN PRETERM INFANTS PRETERM BIRTH COMPLICATION PRETERM INTRAVENTRICULAR HEMORRHAGE SHOCK

Contacts and locations

Locations

UMAE Hospital de Gineco Obstetricia No. 4 "Luis Castelazo Ayala", IMSS

Mexico City, ALVARO OBREGON, 01090, Mexico

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