Simple feeding pause could save preemie lives
NCT ID NCT05213806
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This large international trial tests whether temporarily stopping milk feeds around the time of a blood transfusion can prevent necrotizing enterocolitis (NEC), a severe gut infection, in very premature babies (born before 30 weeks). Over 4,000 infants in Canada and the UK will be randomly assigned to either have feeds paused or continued during transfusions. The goal is to see which approach reduces the risk of NEC and death.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
withholding enteral feeds around blood transfusion
What this could lead to
If it works, this simple change in care could prevent a life-threatening gut disease in thousands of premature babies each year.
What could go wrong
This is a large trial, but the approach is already used in some hospitals, so the difference between groups may be small. Also, withholding feeds might have its own risks for fragile infants.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Barnsley Hospital NHS Foundation Trust
RECRUITINGBarnsley, United Kingdom
Contact Email: •••••@•••••
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Barts Health NHS Trust (3 Hospitals: Royal London Hospital, Whipps Cross Hospital, Newham General Hospital)
RECRUITINGLondon, UK, United Kingdom
Contact Email: •••••@•••••
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Bedfordshire Hospitals NHS Foundation Trust (Luton & Dunstable University Hospital)
RECRUITINGLuton, UK, United Kingdom
Contact Email: •••••@•••••
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Betsi Cadwaladr University Health Board (Glan Cwyd Hospital)
RECRUITINGWales, United Kingdom
Contact Email: •••••@•••••
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Birmingham Women's and Children's NHS Foundation Trust (Birmingham Women's Hospital NICU)
RECRUITINGBirmingham, United Kingdom
Contact Email: •••••@•••••
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Bradford Teaching Hospitals NHS Foundation Trust (Bradford Royal Infirmary)
RECRUITINGBradford, United Kingdom
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Buckinghamshire Healthcare NHS Trust (Stoke Mandeville Hospital)
RECRUITINGAylesbury, United Kingdom
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Calderdale & Huddersfield NHS Foundation Trust (Calderdale Royal Hospital)
RECRUITINGHalifax, United Kingdom
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Chelsea and Westminster Hospital NHS Foundation Trust (Chelsea and Westminster Hospital)
RECRUITINGLondon, UK, United Kingdom
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East Kent University Hospitals NHS Foundation Trust (William Harvey Hospital)
RECRUITINGAshford, United Kingdom
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East and North Essex NHS Foundation Trust - Colchester Hospital
RECRUITINGColchester, United Kingdom
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East and North Essex NHS Foundation Trust - Ipswich Hospital
RECRUITINGIpswich, United Kingdom
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Gloucestershire Hospitals NHS Foundation Trust (Gloucestershire Royal Hospital)
RECRUITINGGloucester, United Kingdom
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IWK Health
RECRUITINGHalifax, Nova Scotia, B3K 6R8, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Imperial College Healthcare NHS Trust (2 Hospitals: St Mary's Hospital & Queen Charlotte's and Chelsea Hospital)
RECRUITINGLondon, UK, United Kingdom
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Lancashire Teaching Hospitals NHS Foundation Trust (Royal Preston Hospital)
RECRUITINGPreston, United Kingdom
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Leeds Teaching Hospitals NHS Trust (Leeds General Infirmary & St James' University Hospital)
RECRUITINGLeeds, United Kingdom
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Liverpool Women's Hospital NHS Foundation Trust (Liverpool Women's Hospital)
RECRUITINGLiverpool, United Kingdom
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Manchester University NHS Foundation Trust (2 Hospitals: St Mary's Hospital - Oxford Road, North Manchester General)
RECRUITINGManchester, United Kingdom
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Manchester University NHS Foundation Trust (Wythenshawe)
RECRUITINGManchester, United Kingdom
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Medway Hospital NHS Foundation Trust (Oliver Fisher Neonatal Unit, Medway Maritime Hospital)
RECRUITINGGillingham, United Kingdom
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NHS Tayside (Ninewells Hospital)
RECRUITINGDundee, United Kingdom
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Norfolk & Norwich University Hospitals NHS Foundation Trust (Norfolk & Norwich University Hospital)
RECRUITINGNorwich, England, United Kingdom
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North Bristol NHS Trust (Southmead Hospital)
RECRUITINGBristol, United Kingdom
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North West Anglia NHS Trust (Peterborough City Hospital)
RECRUITINGPeterborough, United Kingdom
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North West London NHS Trust (Northwick Park Hospital)
RECRUITINGLondon, United Kingdom
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Nottingham University Hospitals NHS Trust (2 Hospitals: City Hospital, Queen's Medical Centre)
RECRUITINGNottingham, United Kingdom
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Oxford University Hospitals NHS FT (John Radcliffe Hospital)
RECRUITINGOxford, United Kingdom
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Portsmouth University Hospitals NHS Trust (Queen Alexandra Hospital)
RECRUITINGPortsmouth, United Kingdom
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Royal Wolverhampton NHS Trust (New Cross Hospital)
RECRUITINGWolverhampton, United Kingdom
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The Hillingdon Hospitals NHS Foundation Trust (Hillingdon Hospital)
RECRUITINGHillingdon, UK, United Kingdom
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The Newcastle Upon Tyne Hospitals NHS Foundation Trust (Royal Victoria Infirmary)
RECRUITINGNewcastle upon Tyne, United Kingdom
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The Shrewsbury & Telford Hospitals NHS Trust (Royal Shrewsbury Hospital)
RECRUITINGShrewsbury, United Kingdom
Contact
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University Hospital Coventry & Warwickshire NHS Trust (University Hospital Coventry)
RECRUITINGCoventry, United Kingdom
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University Hospital Southampton NHS Foundation Trust (Southampton General Hospital)
RECRUITINGSouthampton, United Kingdom
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University Hospitals Birmingham NHS Trust (2 Hospitals: Heartland's Hospital & Good Hope Hospital)
RECRUITINGBirmingham, United Kingdom
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University Hospitals of Derby and Burton NHS Trust (Royal Derby Hospital)
RECRUITINGDerby, United Kingdom
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University Hospitals of Leicester NHS Trust (Leicester Royal Infirmary)
RECRUITINGLeicester, United Kingdom
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Walsall Healthcare NHS Trust (Walsall Manor Hospital)
RECRUITINGWalsall, United Kingdom
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West Hertfordshire Hospitals NHS Trust (Watford General Hospital)
RECRUITINGWatford, United Kingdom
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