Arginine supplement may boost immunity in newborns after bowel surgery

NCT ID NCT05306925

Recruiting now Knowledge-focused Sponsor: University of Liverpool Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether giving extra arginine (a nutrient) to preterm and full-term infants after major bowel surgery or a serious gut infection (necrotising enterocolitis) can improve their immune function. Researchers will measure changes in gene activity related to infection-fighting cells. 48 infants will be split into groups receiving arginine in different ways or standard nutrition. The goal is to understand if arginine can help these vulnerable babies recover better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Arginine (dietary supplement)
What this could lead to: If it works, this could point toward a simple nutritional supplement to help babies fight infections after surgery.
What could go wrong: This is a very early exploratory study with only 48 infants, so results may not be conclusive or lead to a treatment. It focuses on gene activity, not direct health outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastroschisis immune system disorder Malnutrition necrotizing enterocolitis nutritional deficiency disease Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMMUNE SYSTEM AND RELATED DISORDERS NUTRITIONAL DEFICIENCY PRETERM SURGERY

Contacts and locations

Locations

Alder Hey Children's Hospital
RECRUITING

Liverpool, Merseyside, L14 5AB, United Kingdom
Liverpool Women's Hospital
RECRUITING

Liverpool, Merseyside, L8 7SS, United Kingdom

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