Could a higher aspirin dose stop preterm births? large trial launches

NCT ID NCT06980025

Recruiting now Prevention Sponsor: The George Washington University Biostatistics Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking 162 mg of aspirin daily (two baby aspirins) is better than the usual 81 mg for preventing another early birth. It includes 1,800 pregnant women who have previously delivered before 35 weeks. Participants start the medicine between 10 and 15 weeks of pregnancy and continue until nearly 37 weeks. The goal is to see if the higher dose reduces the chance of preterm delivery or fetal death before 35 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aspirin
What this could lead to: If successful, this could establish a higher dose of aspirin as a standard to prevent preterm birth in women with a history of early delivery.
What could go wrong: This is a phase 3 trial, but it only compares two aspirin doses—not a placebo—so the benefit over no treatment is already assumed. Results may not apply to all women, and aspirin carries bleeding risks.

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Conditions

The condition(s) this trial relates to.

obstetric disorder pregnancy disorder Premature Birth Stillbirth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSTETRICAL COMPLICATIONS PRETERM DELIVERY

Contacts and locations

Locations

Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Brown University
RECRUITING

Providence, Rhode Island, 02905, United States
Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44109, United States
Columbia University
RECRUITING

New York, New York, 10032, United States
Duke University
RECRUITING

Durham, North Carolina, 27710, United States
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Magee Women's Hospital of UPMC
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Regents of the University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Alabama - Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of North Carolina - Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Texas - Houston
RECRUITING

Houston, Texas, 77030, United States
University of Utah Medical Center
RECRUITING

Salt Lake City, Utah, 84132, United States

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