Could a higher aspirin dose stop preterm births? large trial launches
NCT ID NCT06980025
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether taking 162 mg of aspirin daily (two baby aspirins) is better than the usual 81 mg for preventing another early birth. It includes 1,800 pregnant women who have previously delivered before 35 weeks. Participants start the medicine between 10 and 15 weeks of pregnancy and continue until nearly 37 weeks. The goal is to see if the higher dose reduces the chance of preterm delivery or fetal death before 35 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Aspirin
What this could lead to
If successful, this could establish a higher dose of aspirin as a standard to prevent preterm birth in women with a history of early delivery.
What could go wrong
This is a phase 3 trial, but it only compares two aspirin doses—not a placebo—so the benefit over no treatment is already assumed. Results may not apply to all women, and aspirin carries bleeding risks.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
Contact
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Brown University
RECRUITINGProvidence, Rhode Island, 02905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Case Western Reserve University
RECRUITINGCleveland, Ohio, 44109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Columbia University
RECRUITINGNew York, New York, 10032, United States
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Duke University
RECRUITINGDurham, North Carolina, 27710, United States
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Hospital of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Magee Women's Hospital of UPMC
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
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Regents of the University of California San Francisco
RECRUITINGSan Francisco, California, 94143, United States
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University of Alabama - Birmingham
RECRUITINGBirmingham, Alabama, 35233, United States
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University of North Carolina - Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27599, United States
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University of Texas - Houston
RECRUITINGHouston, Texas, 77030, United States
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University of Utah Medical Center
RECRUITINGSalt Lake City, Utah, 84132, United States
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