Massive UK trial seeks best drugs to beat pneumonia and COVID-19

NCT ID NCT04381936

Recruiting now Disease control Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This large Phase 3 trial is testing many different treatments, including antiviral drugs and steroids, in 70,000 hospitalized patients with pneumonia (including COVID-19). The goal is to see which treatments reduce deaths and speed up recovery. Researchers compare each treatment against standard care to find what works best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Multiple drugs including lopinavir-ritonavir, dexamethasone, azithromycin, tocilizumab, and others
What this could lead to: If successful, this could identify effective treatments to reduce deaths and shorten hospital stays for patients with pneumonia, including COVID-19.
What could go wrong: This is a large, ongoing trial testing many drugs, so results may vary for each. Some treatments may prove ineffective or have side effects, and findings may not apply to all patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia COVID-19 influenza pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PNEUMONIA

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Belgian sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITING

Brussels, Belgium

Contact Email: •••••@•••••
Clinical Trial Unit, Oxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences
RECRUITING

Kathmandu, Nepal
Dutch sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITING

Utrecht, 3584 BA, Netherlands

Contact Email: •••••@•••••
Eijkman Oxford Clinical Research Unit (EOCRU), Eijkman Institute for Molecular Biology
RECRUITING

Jakarta, Indonesia
Estonian sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITING

Tallinn, Estonia

Contact Email: •••••@•••••
French sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITING

Paris, France

Contact Email: •••••@•••••
Indian Council of Medical Research, Division of Epidemiology and Communicable Diseases
COMPLETED

New Delhi, ICMR-110029, India
Italian sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITING

Roma, Italy

Contact Email: •••••@•••••
Kumasi Center for Collaborative Research in Tropical Medicine KNUST
RECRUITING

Kumasi, Ghana
Nuffield Department of Population Health, University of Oxford
RECRUITING

Oxford, OX3 7LF, United Kingdom

Contact Email: •••••@•••••
Oxford University Clinical Research Unit, Centre for Tropical Medicine
RECRUITING

Ho Chi Minh City, Vietnam

Contact Email: •••••@•••••
Portuguese sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITING

Lisbon, Portugal

Contact Email: •••••@•••••
Romanian sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITING

Bucharest, Romania

Contact Email: •••••@•••••
Spanish sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITING

Barcelona, Spain

Contact Email: •••••@•••••
Swedish sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITING

Stockholm, Sweden

Contact Email: •••••@•••••
Wits Health Consortium
RECRUITING

Johannesburg, South Africa

More trials for these conditions

Other studies related to the condition(s) this trial covers.