Massive UK trial seeks best drugs to beat pneumonia and COVID-19
NCT ID NCT04381936
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This large Phase 3 trial is testing many different treatments, including antiviral drugs and steroids, in 70,000 hospitalized patients with pneumonia (including COVID-19). The goal is to see which treatments reduce deaths and speed up recovery. Researchers compare each treatment against standard care to find what works best.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Multiple drugs including lopinavir-ritonavir, dexamethasone, azithromycin, tocilizumab, and others
What this could lead to
If successful, this could identify effective treatments to reduce deaths and shorten hospital stays for patients with pneumonia, including COVID-19.
What could go wrong
This is a large, ongoing trial testing many drugs, so results may vary for each. Some treatments may prove ineffective or have side effects, and findings may not apply to all patient groups.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Belgian sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITINGBrussels, Belgium
Contact Email: •••••@•••••
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Clinical Trial Unit, Oxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences
RECRUITINGKathmandu, Nepal
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Dutch sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITINGUtrecht, 3584 BA, Netherlands
Contact Email: •••••@•••••
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Eijkman Oxford Clinical Research Unit (EOCRU), Eijkman Institute for Molecular Biology
RECRUITINGJakarta, Indonesia
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Estonian sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITINGTallinn, Estonia
Contact Email: •••••@•••••
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French sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITINGParis, France
Contact Email: •••••@•••••
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Indian Council of Medical Research, Division of Epidemiology and Communicable Diseases
COMPLETEDNew Delhi, ICMR-110029, India
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Italian sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITINGRoma, Italy
Contact Email: •••••@•••••
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Kumasi Center for Collaborative Research in Tropical Medicine KNUST
RECRUITINGKumasi, Ghana
Contact Phone: •••-•••-••••
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Nuffield Department of Population Health, University of Oxford
RECRUITINGOxford, OX3 7LF, United Kingdom
Contact Email: •••••@•••••
Contact
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Oxford University Clinical Research Unit, Centre for Tropical Medicine
RECRUITINGHo Chi Minh City, Vietnam
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Portuguese sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITINGLisbon, Portugal
Contact Email: •••••@•••••
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Romanian sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITINGBucharest, Romania
Contact Email: •••••@•••••
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Spanish sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITINGBarcelona, Spain
Contact Email: •••••@•••••
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Swedish sites are managed by the European Clinical Research Alliance on Infectious Diseases
RECRUITINGStockholm, Sweden
Contact Email: •••••@•••••
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Wits Health Consortium
RECRUITINGJohannesburg, South Africa
Contact Phone: •••-•••-••••