Antidepressant study probes anger processing in healthy youth
NCT ID NCT07424781
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study at the University of Oxford is testing how the antidepressant fluoxetine (Prozac) influences the way healthy young people process anger. Eighty participants aged 18-24 will take either fluoxetine or a placebo for 7 days and complete tasks involving angry faces, words, and frustrating situations. Researchers will also measure heart rate and facial expressions to understand the drug's effects on anger-related responses.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fluoxetine
What this could lead to
If it works, this could help explain how antidepressants influence emotional responses, potentially improving treatment for depression and irritability.
What could go wrong
This is a small, early-stage study in healthy volunteers, not patients. Results may not apply to people with depression, and the short 7-day treatment may not reflect real-world use.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Department of Psychiatry, University of Oxford
RECRUITINGOxford, Oxfordshire, OX3 7JX, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••