Antidepressant study probes anger processing in healthy youth

NCT ID NCT07424781

Recruiting now Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study at the University of Oxford is testing how the antidepressant fluoxetine (Prozac) influences the way healthy young people process anger. Eighty participants aged 18-24 will take either fluoxetine or a placebo for 7 days and complete tasks involving angry faces, words, and frustrating situations. Researchers will also measure heart rate and facial expressions to understand the drug's effects on anger-related responses.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fluoxetine
What this could lead to: If it works, this could help explain how antidepressants influence emotional responses, potentially improving treatment for depression and irritability.
What could go wrong: This is a small, early-stage study in healthy volunteers, not patients. Results may not apply to people with depression, and the short 7-day treatment may not reflect real-world use.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION DEPRESSION - MAJOR DEPRESSIVE DISORDER IRRITABILITY

Contacts and locations

Locations

Department of Psychiatry, University of Oxford
RECRUITING

Oxford, Oxfordshire, OX3 7JX, United Kingdom

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