A 250,000-Person study aims to sharpen heart risk prediction with CT scans

NCT ID NCT05169333

Recruiting now Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This large observational study is collecting CT scans, blood samples, and health data from 250,000 adults to develop and validate new ways of predicting heart disease, stroke, and other cardiometabolic conditions. Participants aged 18 to 99 without active cancer are being enrolled across multiple centers. The study will follow participants for up to 15 years to see how well novel imaging and blood biomarkers predict future health outcomes, including mortality and non-fatal vascular events.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to more accurate ways to predict who is at risk for heart attacks, strokes, and other cardiometabolic diseases, enabling earlier prevention.
What could go wrong: This is an observational study, so it cannot prove cause and effect. The findings may take many years to emerge and may not change clinical practice immediately.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASES CARDIOVASCULAR RISK FACTORS

Contacts and locations

Locations

Assistance Publique - Hôpitaux de Paris
RECRUITING

Paris, France
Barts Health NHS Trust
RECRUITING

London, United Kingdom
Bridging Medical Silos
RECRUITING

Tampa, Florida, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, United States
Brooke Army Medical Center (BAMC)
RECRUITING

San Antonio, Texas, United States
Centro Cardiologico Monzino IRCCS, University of Milan
RECRUITING

Milan, Italy
Cleveland Clinic
RECRUITING

Cleveland, Ohio, United States
Emory University
RECRUITING

Atlanta, Georgia, United States
Friedrich-Alexander-Universitat Erlangen-Nurmberg
RECRUITING

Erlangen, Germany
Golden Jubilee National Hospital
NOT_YET_RECRUITING

Glasgow, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
RECRUITING

London, United Kingdom
GØdstrup Regional hospital
RECRUITING

Aarhus, Denmark
Heart and Lung Centre, New Cross Hospital
RECRUITING

Wolverhampton, United Kingdom
Isola Tiberina-Gemelli Isola Hospital
RECRUITING

Roma, Italy
Leeds Teaching Hospitals NHS Trust
RECRUITING

Leeds, United Kingdom
Lefkos Stavros Clinic
RECRUITING

Athens, Greece
Liverpool heart and chest hospital
NOT_YET_RECRUITING

Liverpool, United Kingdom
Midwest Heart & Vascular Specialists LLC
RECRUITING

Kansas City, Kansas, United States
Milton Keynes University Hospital
RECRUITING

Milton Keynes, United Kingdom
NHS Greater Glasgow and Clyde
NOT_YET_RECRUITING

Glasgow, United Kingdom
NIH National Heart, Lunch, and Blood Institute
RECRUITING

Bethesda, Maryland, United States
National and Kapodistrian University of Athens - Hippokration Hospital
RECRUITING

Athens, Greece
Nicosia Polyclinic
RECRUITING

Nicosia, Cyprus
Oxford University Hospitals NHS Foundation Trust
RECRUITING

Oxford, United Kingdom
Royal Brompton and Harefield Hospitals
RECRUITING

London, United Kingdom
Royal Papworth Hospital NHS Trust
RECRUITING

Cambridge, United Kingdom
Royal United Hospitals Bath NHS Foundation Trust
RECRUITING

Bath, United Kingdom
Sandwell and West Birmingham Hospitals NHS Trust
RECRUITING

Birmingham, United Kingdom
Semmelweis University
RECRUITING

Budapest, Hungary
Seoul National University
RECRUITING

Seoul, South Korea
St Luke's Hospital
RECRUITING

Kansas City, Kansas, United States
Taiwan Kaohsiung Medical University
RECRUITING

Kaohsiung City, Taiwan
The Newcastle Hospitals NHS Foundation Trust
RECRUITING

Newcastle upon Tyne, United Kingdom
The University of Sydney
NOT_YET_RECRUITING

Sydney, Australia
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, United States
University Hospital Ulm
NOT_YET_RECRUITING

Ulm, Germany
University Hospital of Manchester NHS Foundation Trust
NOT_YET_RECRUITING

Manchester, United Kingdom
University Hospitals Birmingham NHS Trust
NOT_YET_RECRUITING

Birmingham, United Kingdom
University Hospitals Leuven
NOT_YET_RECRUITING

Leuven, Belgium
University Hosptials of Leicester NHS Trust
RECRUITING

Leicester, United Kingdom
University of Edinburgh, Royal Infirmary
NOT_YET_RECRUITING

Edinburgh, United Kingdom
University of Medicine and Pharmacy of Targu Mures
RECRUITING

Târgu Mureş, Romania
University of Virginia
RECRUITING

Charlottesville, Virginia, United States
Valleywise Health
RECRUITING

Phoenix, Arizona, United States
Yale University, School of Medicine
RECRUITING

New Haven, Connecticut, United States

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