Carbs vs fats: which diet is better for your heart? oxford launches new study

NCT ID NCT05973539

Recruiting now Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study from the University of Oxford looks at how eating a diet very high in either carbohydrates or fats (65% of calories) changes blood fat levels and liver fat in 60 healthy adults. Participants will follow one of two diets for a short time, and researchers will measure changes in triglycerides and liver fat using blood tests and MRI. The goal is to understand which diet composition may lower the risk of heart disease and diabetes, and whether a person's genes play a role.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Diet: eucaloric diet enriched in either carbohydrates or fat (both contributing to 65% total energy intake)
What this could lead to: If successful, this study could help identify which diet composition is better for heart and metabolic health, and how genes influence that.
What could go wrong: This is a small, early-stage observational study (60 participants) that does not test a treatment. Results may not apply to everyone and won't directly change medical practice.

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Conditions

The condition(s) this trial relates to.

Nutritional and Metabolic Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NUTRITIONAL AND METABOLIC DISEASES

Contacts and locations

Locations

Oxford Centre for Diabetes, Endocrinology and Metabolism
RECRUITING

Oxford, OX3 7LE, United Kingdom
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
RECRUITING

Oxford, OX3 7LE, United Kingdom

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