Pfizer's new weight loss drugs enter Mid-Stage trial

NCT ID NCT07575932

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen May 10, 2026 · Last updated Jun 19, 2026 · Updated 8 times

Summary

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, for weight loss in adults who are overweight or obese. About 872 participants will receive either the drugs or a placebo via injection. The main goal is to see how much weight they lose and if the drugs are safe.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

3A Research
NOT_YET_RECRUITING

Plano, Texas, 75093, United States
AB Clinical Trials
RECRUITING

Las Vegas, Nevada, 89119, United States
AGA Clinical Trials
NOT_YET_RECRUITING

Hialeah, Florida, 33012, United States
Activian Clinical Research
NOT_YET_RECRUITING

Kingwood, Texas, 77339, United States
Alliance Clinical Research Las Vegas (Excel Clinical Research)
NOT_YET_RECRUITING

Las Vegas, Nevada, 89109, United States
Alpine Medical Group
NOT_YET_RECRUITING

Salt Lake City, Utah, 84107, United States
Arizona Clinical Trials (ACT) - Tucson
NOT_YET_RECRUITING

Tucson, Arizona, 85711, United States
Arizona Clinical Trials-Chandler
NOT_YET_RECRUITING

Chandler, Arizona, 85225, United States
Ark Clinical Research
NOT_YET_RECRUITING

Fountain Valley, California, 92708, United States
Ark Clinical Research
NOT_YET_RECRUITING

Long Beach, California, 90815, United States
Atlanta Diabetes Associates
NOT_YET_RECRUITING

Atlanta, Georgia, 30318, United States
Bioluminux Clinical Research
NOT_YET_RECRUITING

Hamilton, New Jersey, 08690, United States
Bioluminux Clinical Research Illinois
NOT_YET_RECRUITING

Naperville, Illinois, 60540, United States
Cedar Health Research - Euless
NOT_YET_RECRUITING

Euless, Texas, 76040, United States
Charter Research
NOT_YET_RECRUITING

Orlando, Florida, 32803, United States
Clinical Research Atlanta
NOT_YET_RECRUITING

Stockbridge, Georgia, 30281, United States
Clinical Research Institute of Arizona
NOT_YET_RECRUITING

Sun City West, Arizona, 85375, United States
Collaborative Neuroscience Research, LLC
NOT_YET_RECRUITING

Los Alamitos, California, 90720, United States
DM Clinical Research
RECRUITING

Tomball, Texas, 77375, United States
DelRicht Research
ACTIVE_NOT_RECRUITING

Mandeville, Louisiana, 70471, United States
DelRicht Research
ACTIVE_NOT_RECRUITING

Prairieville, Louisiana, 70769, United States
DelRicht Research
ACTIVE_NOT_RECRUITING

Springfield, Missouri, 65807, United States
DelRicht Research
RECRUITING

Charlotte, North Carolina, 28210, United States
DelRicht Research
RECRUITING

Hendersonville, Tennessee, 37075, United States
DelRicht Research
NOT_YET_RECRUITING

Vienna, Virginia, 22182, United States
DelRicht Research @ Zomnir Family Medicine
ACTIVE_NOT_RECRUITING

Prosper, Texas, 75078, United States
Diablo Clinical Research, LLC dba Flourish Research
RECRUITING

Walnut Creek, California, 94598, United States
JCCT-JUNO NW Houston
RECRUITING

Houston, Texas, 77040, United States
Johnson County Clinical Trials
NOT_YET_RECRUITING

Lenexa, Kansas, 66219, United States
Koch Family Medicine Clinical Research/Elite Research Network
ACTIVE_NOT_RECRUITING

Morton, Illinois, 61550, United States
Manassas Clinical Research Center
NOT_YET_RECRUITING

Manassas, Virginia, 20110, United States
Mercury Street Medical Group, PLLC
RECRUITING

Butte, Montana, 59701, United States
Monroe Biomedical Research
RECRUITING

Monroe, North Carolina, 28112, United States
New Horizon Research Center
NOT_YET_RECRUITING

Miami, Florida, 33165, United States
Paradigm Clinical Research Centers, LLC
NOT_YET_RECRUITING

San Diego, California, 92108, United States
Paradigm Clinical Research-Modesto
NOT_YET_RECRUITING

Modesto, California, 95355, United States
Paragon Rx Clinical
NOT_YET_RECRUITING

Garden Grove, California, 92840, United States
Patient First Clinical Trials (PFCTRIALS)
NOT_YET_RECRUITING

Lutherville, Maryland, 21093, United States
Piedmont Healthcare
RECRUITING

Statesville, North Carolina, 28625, United States
Preferred Primary Care Physicians
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15236, United States
Preferred Primary Care Physicians
NOT_YET_RECRUITING

Uniontown, Pennsylvania, 15401, United States
TMA Headlands LLC (d/b/a Trial Management Associates)
NOT_YET_RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Tekton Research, LLC.
ACTIVE_NOT_RECRUITING

Edmond, Oklahoma, 73013, United States
Tekton Research, LLC.
ACTIVE_NOT_RECRUITING

San Antonio, Texas, 78258, United States
University Clinical Investigators, Incorporated
NOT_YET_RECRUITING

Tustin, California, 92780, United States
Wasatch Clinical Research, LLC
NOT_YET_RECRUITING

Salt Lake City, Utah, 84107, United States
Westside Center for Clinical Research
NOT_YET_RECRUITING

Jacksonville, Florida, 32205, United States
Worldwide Clinical Trials
NOT_YET_RECRUITING

San Antonio, Texas, 78217, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

PF-08653945 and PF-08653944 (injectable drugs for weight loss)

What this could lead to

If successful, this could lead to a new treatment option for weight loss in people with overweight or obesity.

What could go wrong

This is an early Phase 2 trial, so the drugs may not work better than placebo or could have side effects. Results may not apply to everyone.

Conditions

The condition(s) this trial relates to.

Body Weight Nutritional and Metabolic Diseases nutritional disorder Obesity obesity disorder overnutrition Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BODY WEIGHT NUTRITION DISORDERS NUTRITIONAL AND METABOLIC DISEASES OBESITY OVERNUTRITION OVERWEIGHT OVERWEIGHT AND/OR OBESITY OVERWEIGHT OR OBESITY