New weight loss drugs enter human testing – could they beat placebo?

NCT ID NCT07575932

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 4 times

Summary

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, for weight loss in adults with overweight or obesity. About 872 participants will receive either the drugs or a placebo injection. The main goal is to see how much weight they lose over time and check for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-08653945 and PF-08653944 (injectable drugs for weight loss)
What this could lead to: If successful, this could lead to new medication options for weight loss in people with overweight or obesity.
What could go wrong: This is an early Phase 2 trial, so the drugs may not work better than placebo or could have side effects. Results are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Body Weight Nutritional and Metabolic Diseases nutritional disorder Obesity obesity disorder overnutrition Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BODY WEIGHT NUTRITION DISORDERS NUTRITIONAL AND METABOLIC DISEASES OBESITY OVERNUTRITION OVERWEIGHT OVERWEIGHT AND/OR OBESITY OVERWEIGHT OR OBESITY

Contacts and locations

Locations

3A Research
RECRUITING

Plano, Texas, 75093, United States
AB Clinical Trials
RECRUITING

Las Vegas, Nevada, 89119, United States
AGA Clinical Trials
RECRUITING

Hialeah, Florida, 33012, United States
Accellacare - Wilmington
RECRUITING

Wilmington, North Carolina, 28401, United States
Activian Clinical Research
RECRUITING

Kingwood, Texas, 77339, United States
Aggarwal and Associates Limited
RECRUITING

Brampton, Ontario, L6T 0G1, Canada
Alliance Clinical Research Las Vegas (Excel Clinical Research)
RECRUITING

Las Vegas, Nevada, 89109, United States
Alpine Medical Group
RECRUITING

Salt Lake City, Utah, 84102, United States
Arizona Clinical Trials (ACT) - Tucson
RECRUITING

Tucson, Arizona, 85711, United States
Arizona Clinical Trials-Chandler
RECRUITING

Chandler, Arizona, 85225, United States
Ark Clinical Research
RECRUITING

Fountain Valley, California, 92708, United States
Ark Clinical Research
RECRUITING

Long Beach, California, 90815, United States
Atlanta Diabetes Associates
RECRUITING

Atlanta, Georgia, 30318, United States
Bioluminux Clinical Research
RECRUITING

Hamilton, New Jersey, 08690, United States
Bioluminux Clinical Research Illinois
RECRUITING

Naperville, Illinois, 60540, United States
Bluewater Clinical Research Group Inc.
RECRUITING

Sarnia, Ontario, N7T 4X3, Canada
Cedar Health Research - Euless
RECRUITING

Euless, Texas, 76040, United States
Centricity Research Etobicoke Endocrinology
RECRUITING

Etobicoke, Ontario, M9R 4E1, Canada
Centricity Research Mirabel Multispecialty
NOT_YET_RECRUITING

Mirabel, Quebec, J7J 2K8, Canada
Centricity Research Toronto Manna Multispecialty
RECRUITING

Toronto, Ontario, M9W 4L6, Canada
Charter Research
RECRUITING

Orlando, Florida, 32803, United States
Clinical Research Atlanta
RECRUITING

Stockbridge, Georgia, 30281, United States
Clinical Research Institute of Arizona
RECRUITING

Sun City West, Arizona, 85375, United States
Collaborative Neuroscience Research, LLC
RECRUITING

Los Alamitos, California, 90720, United States
Consano Clinical Research, LLC
RECRUITING

Shavano Park, Texas, 78231, United States
DM Clinical Research
RECRUITING

Tomball, Texas, 77375, United States
DelRicht Research
RECRUITING

Mandeville, Louisiana, 70471, United States
DelRicht Research
RECRUITING

Prairieville, Louisiana, 70769, United States
DelRicht Research
RECRUITING

Springfield, Missouri, 65807, United States
DelRicht Research
RECRUITING

Charlotte, North Carolina, 28210, United States
DelRicht Research
RECRUITING

Hendersonville, Tennessee, 37075, United States
DelRicht Research
RECRUITING

Vienna, Virginia, 22182, United States
DelRicht Research @ Zomnir Family Medicine
RECRUITING

Prosper, Texas, 75078, United States
Diablo Clinical Research, LLC dba Flourish Research
RECRUITING

Walnut Creek, California, 94598, United States
Dr. Anil K. Gupta Medicine Professional Corporation
RECRUITING

Toronto, Ontario, M9V 4B4, Canada
Ecogene-21
NOT_YET_RECRUITING

Chicoutimi, Quebec, G7H 7K9, Canada
JCCT-JUNO NW Houston
RECRUITING

Houston, Texas, 77040, United States
Johnson County Clinical Trials
RECRUITING

Lenexa, Kansas, 66219, United States
Koch Family Medicine Clinical Research/Elite Research Network
RECRUITING

Morton, Illinois, 61550, United States
Manassas Clinical Research Center
RECRUITING

Manassas, Virginia, 20110, United States
Mercury Street Medical Group, PLLC
RECRUITING

Butte, Montana, 59701, United States
Milestone Research Inc.
RECRUITING

London, Ontario, N5W 6A2, Canada
Monroe Biomedical Research
RECRUITING

Monroe, North Carolina, 28112, United States
New Horizon Research Center
RECRUITING

Miami, Florida, 33165, United States
Palm Research Center
RECRUITING

Las Vegas, Nevada, 89128, United States
Paradigm Clinical Research Centers, LLC
RECRUITING

San Diego, California, 92108, United States
Paradigm Clinical Research-Modesto
RECRUITING

Modesto, California, 95355, United States
Paragon Rx Clinical
RECRUITING

Garden Grove, California, 92840, United States
Patient First Clinical Trials (PFCTRIALS)
RECRUITING

Lutherville, Maryland, 21093, United States
Piedmont Healthcare
RECRUITING

Statesville, North Carolina, 28625, United States
Preferred Primary Care Physicians
RECRUITING

Pittsburgh, Pennsylvania, 15236, United States
Preferred Primary Care Physicians
RECRUITING

Uniontown, Pennsylvania, 15401, United States
Preferred Primary Care Physicians, Inc.
RECRUITING

Uniontown, Pennsylvania, 15401, United States
Recherche GCP Research
NOT_YET_RECRUITING

Montreal, Quebec, H1Y 3H5, Canada
San Fernando Valley Health Institute
RECRUITING

Canoga Park, California, 91304, United States
TMA Headlands LLC (d/b/a Trial Management Associates)
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Tekton Research, LLC.
RECRUITING

Edmond, Oklahoma, 73013, United States
Tekton Research, LLC.
RECRUITING

San Antonio, Texas, 78258, United States
Torrance Clinical Research Institute, Inc.
RECRUITING

Lomita, California, 90717, United States
University Clinical Investigators, Incorporated
RECRUITING

Tustin, California, 92780, United States
Viable Clinical Research Corporation
RECRUITING

Bridgewater, Nova Scotia, B4V 3N2, Canada
Wasatch Clinical Research, LLC
RECRUITING

Salt Lake City, Utah, 84107, United States
Washington Center for Weight Management and Research
RECRUITING

Arlington, Virginia, 22206, United States
Westside Center for Clinical Research
RECRUITING

Jacksonville, Florida, 32205, United States
Worldwide Clinical Trials
RECRUITING

San Antonio, Texas, 78217, United States

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