OVERWEIGHT AND/OR OBESITY

This early-stage study tests a new way to deliver semaglutide—a drug used for weight management—using a small, needle-free patch that sticks to the skin. The patch, called VX-201, aims to provide the same benefits as injections without the need for needles. The trial includes hea…

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, for weight loss in adults with overweight or obesity. About 872 participants will receive either the drugs or a placebo injection. The main goal is to see how much weight they lose over…

This Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…

This study tests whether a supervised, equipment-free high-intensity interval training (HIIT) program can improve heart and muscle fitness, body composition, and blood markers in adults aged 18-55 who are overweight or obese. Participants will do body-weight exercises in small gr…

This study tests a new, non-surgical procedure called Endoscopic Radial Compression Gastroplasty (ERCG) that uses a clip-and-loop system to reduce stomach size, helping with weight loss. It is for Chinese adults aged 18-65 with a BMI of 24.0-37.4 who have not succeeded with diet …

This study tests an experimental oral drug called ecnoglutide in 84 Chinese adults who are overweight or obese. The main goal is to check safety and how the body processes the drug, while also measuring weight changes. Participants take either the drug or a placebo daily for seve…

This study tests whether a six-month program of dietary counseling and group exercise can reduce heart disease risk in adults with severe mental illnesses like schizophrenia or bipolar disorder. Around 70 participants will either receive the lifestyle program plus usual care, or …

This study tests whether a daily powder containing fiber and plant compounds (inulin, resveratrol, quercetin) can reduce brain inflammation in 120 overweight women aged 35-60 who are going through menopause. Participants take the supplement or a placebo for 6 months, and research…

This study tests a family-based program using a mobile app to help prevent childhood obesity in school-age children (5-9 years old) in Sonora, Mexico. The program includes guidance on healthy eating, physical activity, and positive parenting. Researchers will compare families who…

This study tests whether 10 minutes of daily brain games on a phone can help teens aged 14-17 with overweight improve their self-control around food. Over three weeks, participants play games designed to strengthen inhibitory control and receive a short nutrition lesson. The goal…

This early-stage study tests an experimental drug called PF-08653944 in 20 overweight or obese adults. Researchers want to see how it affects the speed at which the stomach empties food, using a common painkiller as a marker. The main goals are to understand the drug's effects an…