OVERWEIGHT AND/OR OBESITY

This study tests whether adding a chatbot to a smartphone weight loss program helps young adults lose weight and stay engaged. Twenty overweight or obese adults will use either a standard app or one with a chatbot for 12 weeks. Researchers will measure how often participants use …

This study tests whether a 6-month program of dietary counseling and group exercise can reduce heart disease risk in people with severe mental illnesses like schizophrenia or bipolar disorder. About 70 adults will either receive the lifestyle program plus usual care, or usual car…

This study tests a new medicine called MET097, given as a weekly shot under the skin, to help adults with overweight or obesity and type 2 diabetes lose weight. About 1,000 people will take part for 21 months, with some receiving the study drug and others a placebo. The goal is t…

This study tests a new, non-surgical stomach procedure called Endoscopic Radial Compression Gastroplasty (ERCG) combined with lifestyle changes for weight loss in Chinese adults who are overweight or have mild-to-moderate obesity. About 216 participants will be randomly assigned …

This study tests an experimental oral tablet called ecnoglutide in 84 Chinese adults who are overweight or obese. The main goal is to check the drug's safety and how the body processes it, while also measuring weight loss and other body changes. Participants take the tablet or a …

This study tests whether a daily dietary supplement containing fiber and plant compounds can reduce brain inflammation in overweight women going through menopause. The goal is to see if changing gut bacteria through diet can protect brain health and lower the risk of cognitive de…

This study tests a family-based program using a mobile app and coaching to prevent obesity in children aged 5 to 9 in Sonora, Mexico. About 40 families will be split into two groups: one gets the app and support, the other gets standard care. The goal is to see if the program imp…

This study tests whether a supervised 10-week whole-body high-intensity interval training (HIIT) program can improve cardiorespiratory fitness, muscle strength, body composition, and blood markers in adults aged 18-55 who are overweight or obese (BMI 25-35). Participants will do …

This early-stage study tests a medicine called PF-08653944 in 20 adults who are overweight or have obesity. The goal is to see how it changes the speed at which the stomach empties food after a meal. Researchers will also check for side effects. The results will help plan future …