Could a past cold make your lungs more sensitive to air pollution?

NCT ID NCT05773001

Recruiting now Knowledge-focused Sponsor: Robert Tighe, MD Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether having a respiratory infection in the past changes how your lungs react to ozone, a common air pollutant. One hundred healthy adults will breathe ozone while exercising and have their lung cells sampled. The goal is to understand why some people may be more susceptible to lung inflammation after environmental exposures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ozone (O3) gas
What this could lead to: If successful, this could help identify why some people are more prone to lung inflammation from air pollution after a respiratory infection.
What could go wrong: This is an early-phase study with only 100 participants, so results may not apply to everyone. It is designed to gather knowledge, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for RESPIRATORY VIRAL INFECTION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

COVID-19 viral respiratory tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESPIRATORY VIRAL INFECTION SARS-COV 2 PNEUMONIA

Contacts and locations

Locations

Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.