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Massive study aims to unlock secrets of COVID-19 immunity

NCT ID NCT04582903

Recruiting now Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study, run by the National Institute of Allergy and Infectious Diseases, collects blood and stool samples from up to 5,000 people of all ages who have or had COVID-19, as well as those heavily exposed but uninfected. Researchers will analyze immune responses and genetic factors to understand why outcomes vary so widely. No treatments are tested—this is purely a knowledge-gathering effort to guide future therapies and vaccines.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this study could reveal why some people get very sick from COVID-19 while others don't, pointing toward better treatments and vaccines.
What could go wrong
This is an early, exploratory study that only collects samples—it does not test any treatment. Findings may not lead to direct benefits for participants or the public.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 INFECTION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Niaid/Lcim

    RECRUITING

    Rockville, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.