New nasal spray COVID-19 booster could replace needles

NCT ID NCT06821126

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: ANRS, Emerging Infectious Diseases Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a new intranasal (nose spray) COVID-19 booster vaccine, LVT-001, with the standard mRNA booster shot in 238 healthy adults. The goal is to see if the nasal vaccine is safe and triggers a strong immune response, especially in the nose and throat where the virus first enters. The trial has two phases: first, testing different doses for safety, then comparing the best dose to the mRNA booster.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LVT-001 (intranasal COVID-19 vaccine) and Pfizer-BioNTech mRNA vaccine (Cormirnaty)
What this could lead to: If successful, this could provide a needle-free, easier-to-take booster option that may better protect against COVID-19 at the nose and mouth, where the virus enters.
What could go wrong: This is an early Phase I/II trial with only 238 participants, so results may not apply to everyone. The intranasal vaccine is first-in-human, so safety and effectiveness are still unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY

Contacts and locations

Locations

APHP - Hôpital Cochin - Centre d'Investigation Clinique de Vaccinologie Cochin-Pasteur 1417
NOT_YET_RECRUITING

Paris, 75679, France
CHRU de Tours - Centre d'Investigation Clinique 1415
RECRUITING

Tours, 37044, France
CHU Dijon Bourgogne - Centre d'Investigation Clinique 1432
NOT_YET_RECRUITING

Dijon, 21079, France
CHU de Saint-Etienne - Service des Maladies Infectieuses
NOT_YET_RECRUITING

Saint-Priest-en-Jarez, 42270, France
HCL - Hôpital de la Croix-Rousse - Service des Maladies Infectieuses et Tropicales
NOT_YET_RECRUITING

Lyon, 69004, France

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