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Could a simple vitamin save lives in the ICU?

NCT ID NCT03188796

Recruiting now Disease control Sponsor: Medical University of Graz Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether giving high doses of vitamin D3 to critically ill patients with very low vitamin D levels can reduce the chance of death within 28 days. The trial will include 2,400 adults in intensive care units. If successful, this cheap and easy treatment could be quickly adopted worldwide.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Vitamin D3 (cholecalciferol)
What this could lead to
If it works, this could provide a simple, inexpensive way to lower death rates in critically ill patients with severe vitamin D deficiency.
What could go wrong
This is a confirmatory trial, but the earlier study was small and the benefit was seen only in a subgroup. There is also a risk of side effects like high calcium levels.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 Critical Illness vitamin D deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID19 CRITICAL ILLNESS VITAMIN D DEFICIENCY

Contacts and locations

Locations

  • Barmherzige Brüder

    RECRUITING

    Vienna, Austria

  • Barmherzige Schwestern

    RECRUITING

    Linz, Austria

  • CHR Citadelle

    TERMINATED

    Liège, Belgium

  • CHU Ambroise Pare

    TERMINATED

    Mons, Belgium

  • CHU de Charleroi

    TERMINATED

    Charleroi, Belgium

  • Erasme Hospital

    TERMINATED

    Brussels, Belgium

  • Kaiser Franz Josef Spital Wien

    SUSPENDED

    Vienna, Austria

  • Kepler Universitätsklinikum Linz

    RECRUITING

    Linz, Austria

  • Klinikum am Wörthersee

    RECRUITING

    Klagenfurt, Austria

  • Krankenhaus Schwarzach

    TERMINATED

    Schwarzach im Pongau, Austria

  • LKH Enzenbach

    RECRUITING

    Enzenbach, Austria

  • LKH Feldbach

    TERMINATED

    Feldbach, Austria

  • LKH Hochsteiermark Standort Leoben

    RECRUITING

    Leoben, Austria

  • LKH Villach

    RECRUITING

    Villach, Austria

  • Medical University of Graz

    RECRUITING

    Graz, Austria

  • Medical University of Vienna

    RECRUITING

    Vienna, Austria

  • University Hospital Wuerzburg

    RECRUITING

    Würzburg, Germany

  • University of Birmingham

    RECRUITING

    Birmingham, United Kingdom

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