Could a simple vitamin save lives in the ICU?
NCT ID NCT03188796
First seen Nov 21, 2025 · Last updated Jun 23, 2026 · Updated 31 times
Summary
This study is testing whether giving high doses of vitamin D3 to critically ill patients with very low vitamin D levels can reduce the chance of death within 28 days. The trial will include 2,400 adults in intensive care units. If successful, this cheap and easy treatment could be quickly adopted worldwide.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Barmherzige Brüder
RECRUITINGVienna, Austria
Contact
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Barmherzige Schwestern
RECRUITINGLinz, Austria
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CHR Citadelle
TERMINATEDLiège, Belgium
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CHU Ambroise Pare
TERMINATEDMons, Belgium
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CHU de Charleroi
TERMINATEDCharleroi, Belgium
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Erasme Hospital
TERMINATEDBrussels, Belgium
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Kaiser Franz Josef Spital Wien
SUSPENDEDVienna, Austria
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Kepler Universitätsklinikum Linz
RECRUITINGLinz, Austria
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Klinikum am Wörthersee
RECRUITINGKlagenfurt, Austria
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Krankenhaus Schwarzach
TERMINATEDSchwarzach im Pongau, Austria
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LKH Enzenbach
RECRUITINGEnzenbach, Austria
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LKH Feldbach
TERMINATEDFeldbach, Austria
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LKH Hochsteiermark Standort Leoben
RECRUITINGLeoben, Austria
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LKH Villach
RECRUITINGVillach, Austria
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Medical University of Graz
RECRUITINGGraz, Austria
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Medical University of Vienna
RECRUITINGVienna, Austria
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University Hospital Wuerzburg
RECRUITINGWürzburg, Germany
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University of Birmingham
RECRUITINGBirmingham, United Kingdom
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vitamin D3 (cholecalciferol)
What this could lead to
If it works, this could provide a simple, inexpensive way to lower death rates in critically ill patients with severe vitamin D deficiency.
What could go wrong
This is a confirmatory trial, but the earlier study was small and the benefit was seen only in a subgroup. There is also a risk of side effects like high calcium levels.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.