Could a different way of pedaling rebuild muscles after severe COVID-19?

NCT ID NCT04649086

Terminated Disease control Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study tests whether a specific type of exercise, called eccentric exercise, can help people recover muscle strength and walking ability after a severe COVID-19 infection. Participants, aged 18 to 80, will be randomly assigned to either eccentric or standard concentric exercise sessions on a stationary bike over two months. The main goal is to see if eccentric exercise leads to greater improvements in walking capacity, as measured by the six-minute walk test.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Eccentric exercise rehabilitation using a cycloergometer
What this could lead to: If eccentric exercise proves more effective, it could offer a faster, more efficient rehabilitation path for people recovering from severe COVID-19, potentially reducing care costs and duration.
What could go wrong: This is a small, early-stage trial, so results may not apply broadly. Eccentric exercise may be harder to tolerate or carry risks for some patients, and the benefits over standard exercise are not yet proven.

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Conditions

The condition(s) this trial relates to.

COVID-19 Muscle Weakness Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID19 MUSCLE WEAKNESS SARCOPENIA

Contacts and locations

Locations

CHU de Clermont-Ferrand

Clermont-Ferrand, 63000, France
CHU de Dijon

Dijon, 21000, France
CHU de Saint-Etienne

Saint-Etienne, 42000, France

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