SARCOPENIA

This study tests whether a device called MyokinE100, which sends electrical signals to the thigh muscles, is safe and practical for use in the ICU. It includes 50 critically ill patients with sepsis who are at risk of muscle weakness. Half will receive standard care plus daily 60…

This study tested whether a simple, low-cost exercise program using elastic bands could help older adults in rural long-term care facilities delay or prevent sarcopenia, a condition that causes muscle loss and weakness. Sixty participants aged 60 and older did 30-minute sessions …

This study tests whether taking branched-chain amino acid (BCAA) supplements for three months after knee replacement surgery can help improve muscle mass and strength in patients with sarcopenia (age-related muscle loss). About 140 adults aged 40 to 100 will be randomly assigned …

This study tests whether taking silkworm pupa powder daily for four months can improve thinking, daily living, and nutrition in people with Alzheimer's disease. About 300 participants will receive either the powder or a placebo. Researchers will track changes in memory, frailty, …

This pilot study tests whether taking creatine while doing resistance training can help prevent muscle loss in people starting GLP-1 weight-loss drugs. 40 adults will be assigned to either creatine or a placebo during a 12-week exercise program. The goal is to see if this combina…

This study looks at whether giving patients with bone or soft tissue sarcoma a special nutritional supplement twice daily before surgery can reduce complications and help maintain muscle mass. About 100 adults scheduled for tumor removal will be randomly assigned to receive eithe…

This study tests a 4-week prehabilitation program combining exercise, nutritional supplements, and psychological support for patients with sarcopenia (muscle loss) who are about to have pancreatic cancer surgery. The goal is to see if this program reduces serious complications li…

This Phase 2 study tests whether a Traditional Chinese Medicine (TCM) herbal formula can improve muscle strength and bone health in pre-frail adults aged 65 and older, compared to the nutritional supplement HMB. Over 24 weeks, 90 participants will take either the TCM powder or HM…

This phase 3 trial tests whether high-dose vitamin D (50,000 IU once a month) can improve muscle health in adults aged 21-65 who have low vitamin D levels after surgery. The study will measure vitamin D levels at 3, 6, and 12 months. If successful, it could point to a simple way …

This study looks at whether eating protein evenly throughout the day, combined with a regular exercise program, can improve nutrition, muscle mass, and strength in people with end-stage liver disease awaiting a transplant. 90 participants will be split into three groups: one with…

This study tests whether adding the CytoSorb blood-filtering device to standard hospital care can better remove waste products like bilirubin and ammonia in people with sudden worsening of chronic liver disease. Twenty adults with severe liver failure will receive the device for …

This study tests whether eating a special oil (high in linoleic acid) every day can help older adults with muscle loss (sarcopenia) build stronger muscles and improve mobility. Researchers will give 66 participants either the oil or a placebo for a period, then measure changes in…

This study tests whether a virtual group exercise program combined with health education can lower fall risk and increase physical activity in older veterans who have both obesity and signs of muscle loss (sarcopenia). About 50 veterans aged 55 and older will take part. The goal …

This study looks at whether whole body vibration therapy, added to usual care, can improve muscle mass, strength, and function in older adults who are starting to become frail. About 40 people aged 65 and older will be randomly assigned to receive either vibration therapy plus us…

This study tests whether a drug called nandrolone decanoate, combined with a structured exercise and diet program, can improve strength and mobility in older adults with sarcopenia (age-related muscle loss). About 168 people aged 60–99 will receive either the drug or a placebo, p…

This study looks at whether a type of dialysis done more often but with a slower flow can help kidney patients who have been in the hospital regain muscle strength and function. About 50 adults with end-stage kidney disease will take part. They will do a rehab program with exerci…

This study tests whether taking creatine HCl daily for 12 weeks can improve muscle strength, body composition, and brain function in adults over 60 with sarcopenia (age-related muscle loss). Researchers will measure handgrip strength, fitness, and blood markers. The goal is to se…

This study looks at whether adding branched-chain amino acid (BCAA) supplements to a standard liver procedure (TIPS) can help reverse muscle loss (sarcopenia) in people with cirrhosis and high blood pressure in the liver. About 164 patients will be randomly assigned to receive ei…

This study tests a specialized clinic designed to diagnose and treat muscle loss (sarcopenia) in people with COPD. The clinic brings together a team of experts to provide targeted care. Researchers will see if this approach improves muscle mass and function, and reduces hospitali…

This study tests a new technology (HD-sEMG) that monitors muscle signals to better diagnose sarcopenia—a condition where older adults lose muscle mass and strength. Researchers will enroll 846 people aged 75 and older who are hospitalized and at risk for sarcopenia. The goal is t…

This study compares using a tape measure around the calf to a standard X-ray method for diagnosing sarcopenia (age-related muscle loss) in hospitalized adults aged 75 and older. Researchers will measure calf, arm, and thigh circumferences in 298 participants and see how well thes…

This study tests whether a 12-week smartphone-based program can help older adults at risk of sarcopenia (muscle loss) maintain muscle mass and strength. The program includes exercise videos, nutrition tips, daily reminders, and a point system to keep users engaged. Sixty particip…

This study tests a digital therapeutic device (exoDTx) – a mobile app that guides personalized resistance exercises at home – to see if it can improve muscle strength in people with sarcopenia (age-related muscle loss). 130 participants will either use the app for 12 weeks or rec…

This study looks at whether taking creatine supplements while doing supervised weight training for 12 weeks can help men with prostate cancer who are on hormone therapy (ADT) maintain or improve their muscle mass, strength, and physical function. ADT often causes muscle loss and …

This study tests whether a 6-week supervised pool exercise program can improve muscle strength, mass, and quality of life in adults aged 65 and older with sarcopenia (age-related muscle loss). Participants will do 15 sessions of water-based exercises over 6 weeks. Researchers wil…

This study looks at whether taking krill oil supplements for six months can increase muscle strength and improve walking in healthy adults aged 65 and older. Researchers will measure grip strength, leg muscle size, and how well the nerves and muscles communicate. The goal is to f…

This study tests whether a home-based exercise and nutrition program, called prehabilitation, can improve physical function in adults aged 65 and older with breast cancer before they have surgery. The program includes strength, balance, and flexibility exercises tailored to each …

This pilot study tests whether a physical activity program can help children aged 5–17 with acute lymphoblastic leukemia maintain muscle strength and avoid frailty during early treatment. Kids who show signs of weakness after five weeks of chemotherapy are randomly assigned to ei…

This study tests whether a 12-session pulmonary rehabilitation program—including breathing exercises, resistance training, and treadmill walking—can help patients with advanced non-small-cell lung cancer maintain muscle mass, improve lung function, and reduce inflammation. The go…

This study tests whether a 12-week multimodal exercise program—combining supervised training, home exercises, and digital support—can improve muscle function, physical performance, and blood sugar control in adults aged 45 to 85 with both type 2 diabetes and sarcopenia (age-relat…

This study looks at whether high-intensity interval training (HIIT) is better than moderate continuous exercise for treating muscle loss (sarcopenia) in people who have had an ischemic stroke. Researchers will measure changes in thigh muscle thickness, grip strength, walking abil…

This study tests whether taking essential amino acids (protein building blocks) combined with resistance exercise for 12 weeks can improve muscle strength and function in people on hemodialysis who have sarcopenia (muscle loss). Forty participants will be randomly assigned to the…

This study compares two exercise programs for women who have finished breast cancer treatment. One group does supervised resistance and relaxation exercises at a facility, while the other follows a home-based resistance routine. The goal is to see which approach better improves m…

This study tests whether a 12-week supervised exercise program done during dialysis can improve muscle mass, strength, sleep, and quality of life in adults over 40 with chronic kidney disease. Participants are randomly assigned to either exercise during the first 90 minutes of di…

This pilot study tests whether taking a daily polyphenol supplement (from red leaf lettuce) alongside a 12-week exercise program can improve physical performance in adults over 60. The main goal is to see if the study is feasible—can people stick with it? Researchers will also me…

This study tests whether electroacupuncture (acupuncture with mild electrical pulses) combined with standard rehabilitation can improve walking ability in elderly people with sarcopenia (age-related muscle loss). 120 participants aged 60-95 will be randomly assigned to receive ei…

This pilot study tests whether whole-body electrical muscle stimulation (WB-EMS) combined with exercise can improve muscle activation and physical function in healthy older adults aged 65 and older. Participants will use a special suit with electrodes that stimulate major muscle …

This study tests whether a 2-week exercise and nutrition program is safe and doable for people about to have head and neck cancer surgery. About 20 adults with a new diagnosis will take part. The goal is to see if the program helps patients feel stronger before their operation.

This study tests whether taking silkworm pupa powder daily for 3 months can improve nutrition, muscle strength, and frailty in people with Alzheimer's disease. Researchers will compare the powder to a placebo in 200 participants aged 50-90. The goal is to see if it helps with wei…

This study looks at a new tool called the Functional Muscle-Bone Incongruity Index (FKUI) that combines handgrip strength and bone density measurements. Researchers want to see if this combined approach gives a fuller picture of muscle and bone health than looking at each measure…

This study looks at 110 patients aged 80 and older who are in the hospital for acute heart failure. Researchers will use ultrasound and blood tests to measure muscle loss (sarcopenia) and see how it affects their recovery over six months. The goal is to find better ways to predic…

This study looks at 100 adults aged 65 and older with fibrosing interstitial lung disease, a condition that scars the lungs and shortens life. Researchers will assess frailty and muscle loss (sarcopenia) using questionnaires and tests to see if these factors predict hospital stay…

This study looks at whether a new ultrasound technique can measure fat inside the muscles of older adults in rehabilitation. Researchers want to see if more muscle fat makes it harder to regain physical function after a hospital stay. The study will involve 115 people aged 75 and…

This observational study looks at whether sarcopenia (muscle loss) and frailty affect how the muscle relaxant rocuronium works in older patients having surgery. Researchers will monitor 100 adults aged 65 and older to see how fast the drug takes effect and how long it lasts. The …

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

This study looks at how common muscle loss and weakness are in people with liver cirrhosis, and how malnutrition plays a role. Researchers will use ultrasound to measure muscle size and a grip test to check strength. The goal is to better understand the problem and its impact on …

This study looks at how a new type of whey protein, called 'super-whey,' affects muscle building in older adults. Researchers will test three different doses to see which one works best, both at rest and after exercise. The goal is to find a low-dose protein option that helps mai…

This study looks at why older adults respond differently to the same exercise program. Researchers will have 250 healthy adults aged 60+ do a mix of cycling and strength training three times a week. The goal is to understand what makes exercise more effective for some, so future …

This study is following 5,000 middle-aged and older adults in Taiwan who are Tzu Chi volunteers and eat plant-based or vegetarian diets. Researchers want to see if these diets are linked to healthier aging, including better memory, stronger muscles, and lower risk of frailty. Par…

This study looks at why people with chronic kidney disease (CKD) often lose muscle mass and strength, a condition called sarcopenia. Researchers will follow 1,000 adults with CKD to find risk factors for sarcopenia and see how it affects their health over time. The goal is to bet…

This study follows 142 adults having lung cancer surgery to see if measuring nutrition and muscle loss can help predict complications, hospital stay, and survival. Participants get blood tests, CT scans, and ultrasound before surgery. The goal is to create a better risk score to …

This study tests whether showing older adults with sarcopenia (age-related muscle loss) their movement speed during leg presses can improve muscle activation, motivation, and perceived effort. Sixty participants will visit the lab once a week for three weeks to perform leg press …

This study follows 100 women with early-stage breast cancer for two years after surgery and treatment. Researchers will measure changes in muscle mass, body fat, and strength using simple tests. The goal is to understand how the body recovers and what factors affect quality of li…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…

This study looks at why a procedure called TIPS (which helps blood flow in the liver) might also improve muscle loss (sarcopenia) in people with advanced liver disease. Researchers will measure a protein called FGF21 in the blood and track changes in muscle mass and strength over…

This study follows 250 adults in the ICU to understand frailty and muscle wasting. Researchers will use ultrasound, blood tests, and questionnaires to track changes. The goal is to find factors that can be changed to improve recovery and reduce long-term disability.

This study aims to find out how common malnutrition and muscle loss (sarcopenia) are among adults visiting hospital clinics in Turkey. Researchers will screen 7,500 people aged 18 and older using questionnaires and simple physical tests like grip strength and calf measurement. No…

This study looks at whether easy, quick tests for frailty and muscle strength can help predict complications after major abdominal surgery in adults aged 65 and older. About 100 participants will do brief assessments during a routine pre-surgery visit, and researchers will check …

This study looks at the gut bacteria of older adults with sarcopenia (age-related muscle loss) and compares them to healthy older and young adults. The goal is to find differences that could help create probiotics to treat sarcopenia. Researchers will enroll 150 people aged 65-90…

This study looks at whether low muscle mass (myopenia) is linked to severe side effects from chemotherapy in older adults with advanced colorectal cancer. Researchers will follow 300 newly diagnosed patients to track toxicities and survival. The goal is to better understand who m…

This study will follow 20,000 adults in rural China for three years to understand how chronic diseases like high blood pressure, diabetes, and frailty develop. Participants will provide health data and samples to build a comprehensive database. The goal is to create better diseas…

This study looks at how a person's fat-free mass (like muscle) affects the dose and side effects of the chemotherapy drug carboplatin in patients with advanced non-small cell lung cancer. Researchers will track 132 patients to see if body composition is linked to toxicity. The go…

This study looks at whether sarcopenia (age-related muscle loss) influences the type and location of rotator cuff tears. Researchers will assess muscle health in 104 adults aged 40-75 with shoulder problems using ultrasound and strength tests, then compare their MRI scans to see …

This study looks at whether women with gestational diabetes (GDM) experience muscle loss, known as sarcopenia, and how this might affect pregnancy outcomes and thinking skills. Researchers will test 200 pregnant women using muscle strength and function tests, along with standard …

This study tracks 100 cancer survivors aged 18–74 to see how common muscle loss (sarcopenia) and cognitive problems ('chemo brain') are after treatment. Participants undergo physical and mental assessments. The goal is to better understand these long-term side effects and guide p…

This study looks at how the type of anesthesia used during colorectal cancer surgery affects muscle loss and strength after the operation. Researchers will measure muscle size and function using ultrasound, grip strength tests, and body composition scans. The goal is to find out …

This study looks at how diet and gut bacteria are linked to sarcopenia, a condition where older adults lose muscle mass and strength. Researchers will analyze the diets and gut microbes of 1,220 people aged 60 and older. The goal is to understand if certain diets cause inflammati…

The SMILE study is tracking 10,000 adults aged 18 and older to see how sarcopenia (age-related muscle loss) and metabolic diseases like diabetes influence overall health and lifespan. Researchers will collect data from medical records, tests, and surveys over time. This is an obs…