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Can High-Intensity workouts help stroke survivors regain muscle?

NCT ID NCT07456956

Symptom relief Sponsor: Fenerbahce University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether high-intensity interval training (HIIT) is better than moderate continuous exercise for treating muscle loss (sarcopenia) in people who have had an ischemic stroke. Researchers will measure changes in thigh muscle thickness, grip strength, walking ability, and quality of life in 32 participants over 6 weeks. The goal is to find the best exercise approach to improve recovery and daily function after a stroke.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MCIT) exercise programs
What this could lead to
If successful, this study could show that HIIT is a more effective exercise approach than moderate training for rebuilding muscle and improving mobility after a stroke.
What could go wrong
This is a small, early-stage trial with only 32 participants, so results may not apply to all stroke survivors. Exercise intensity may be hard for some to tolerate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * First-ever stroke. * Age 18 years or older. * Diagnosis of ischemic stroke. * Stroke duration between 1-6 months (subacute phase). * Modified Rankin Scale score \< 3. * Mini-Mental State Examination (MMSE) score ≥ 24. * Brunnstrom lower extremity motor stage between Stage III-V. * Lower extremity functional capacity sufficient to allow exercise participation (able to ambulate at least with an assistive device). * Lower extremity spasticity ≤ 2 according to the Modified Ashworth Scale. * Independent sitting balance (able to sit unsupported for at least 30 seconds). * Presence of sufficient voluntary active movement in the lower extremity to permit exercise application. * Ability to communicate. * Willingness to participate in the study and provision of written informed consent. Exclusion Criteria: * Presence of hemispatial neglect. * History of recurrent stroke. * Presence of a psychiatric disorder. * Presence of orthopedic, neurological, or cardiopulmonary conditions that would contraindicate the planned exercise protocols.

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Conditions

The condition(s) this trial relates to.

ischemic stroke Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sarcopenia Stroke, ischemic

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Fenerbahçe University

    RECRUITING

    Istanbul, Ataşehir, 34758, Turkey (Türkiye)

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