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This study tests a new, simpler weight training program called D-STORM for adults with type 2 diabetes. The program uses easier exercises to build muscle and improve blood sugar control. Over 12 weeks, 56 participants will either do the training plus usual care or just usual care…

This study tests a 12-week resistance exercise program designed to help older adults with sarcopenia (age-related muscle loss). The program uses behavior change techniques like education, rewards, and reminders to keep participants on track. One hundred community-dwelling adults …

This study will test whether a 24-week home-based resistance exercise program, when added to the weight-loss drug tirzepatide, helps overweight and obese adults maintain muscle mass and strength. About 108 people starting tirzepatide will be randomly assigned to either exercise p…

This study tests whether specially designed retort meals can improve muscle health, thinking skills, and nutrition in low-income older adults in Malaysia. Seventy participants aged 60-84 will receive the meals for 12 weeks, while a control group does not. The goal is to see if th…

This study tests a new capsule, TJ0113, in 204 older adults (age 60+) with sarcopenia, a condition causing muscle loss and weakness. Participants take the capsule or a placebo daily for 26 weeks. The main goal is to see if the drug improves walking speed, a key measure of muscle …

This study tests a volunteer-led lifestyle program for older adults (60+) with sarcopenia, a condition causing muscle loss and weakness. The program includes workshops on nutrition and exercise, supported by nurses and trained volunteers. Researchers will measure changes in muscl…

This study tests a combination of high-protein supplements, mobility-based physical therapy, and neuromuscular electric stimulation in older adults (60+) who have been in the ICU for at least two weeks and now have muscle weakness. The goal is to see if this approach can improve …

This study tests different weight-loss strategies for adults aged 50 to 75 with obesity. Participants will follow either a high-protein or standard-protein diet for 16 weeks. Those who don't respond well may then receive extra protein supplements or resistance exercise training. …

This study tests a 12-week home exercise program combining aerobic and resistance training for older adults (60+) with type 2 diabetes and early muscle weakness. The goal is to see if short, regular workouts can improve physical activity levels and muscle strength. About 73 parti…

This study tests whether a 32-week multicomponent exercise program can improve muscle quality and function in women over 60 with sarcopenia. Forty participants will do strength, balance, aerobic, and flexibility exercises. The goal is to see if the program leads to better muscle …

This study tests whether walking in a robotic exoskeleton combined with mild electrical stimulation of the spinal cord can improve muscle and bone health in people with chronic spinal cord injury. About 24 participants will be assigned to either active or sham stimulation during …

This study tests whether adding a traditional Chinese medicine formula (Huangjing Yangji) to resistance exercise improves physical function more than exercise alone in older adults with sarcopenia (age-related muscle loss). About 106 participants will take either the herbal granu…

This study tests whether a special cardiac rehabilitation program can improve muscle strength and reduce inflammation in elderly patients with both heart disease and sarcopenia (age-related muscle loss). One hundred participants will either receive rehab plus standard care or sta…

This study tests whether roxadustat, a drug currently used to treat anemia in kidney disease, can also improve sarcopenia (muscle loss) in patients on hemodialysis. Sixty adults with end-stage kidney disease and anemia will receive either roxadustat or standard erythropoietin. Re…

This study will check if a muscle ultrasound can reliably detect muscle loss (sarcopenia) in 140 adults getting a kidney transplant. Researchers will compare ultrasound results with a standard body-composition test before and up to one year after transplant. If it works, this cou…

This study is testing a new AI software called Soma that automatically measures muscle and fat from CT scans. Researchers will compare the software's measurements to those made by three expert radiologists using 200 CT scans from public databases. The goal is to see if the AI is …

This study will create a smart AI tool that uses muscle tests and scans to diagnose sarcopenia—age-related muscle loss—more accurately. Researchers will also check if a rehabilitation exercise program can improve muscle function in adults 65 and older who are at risk. The goal is…

This study tests whether eating all meals within an 8-hour window (between early morning and early afternoon) combined with morning exercise can prevent sarcopenia—age-related muscle loss—in postmenopausal women with obesity and type 2 diabetes. Forty-five women will follow eithe…

This study tests whether a program of exercise, lifestyle changes, and a smart chatbot can prevent osteoporosis and sarcopenia in 8,336 adults aged 40-60. Participants are split into two groups: one gets active support with structured workouts and reminders, the other gets basic …

This study tests a program called SHAPE that combines physical activity and nutrition advice for older adults after they leave the hospital for a severe flare-up of chronic lung disease. The goal is to reduce frailty and muscle loss, and improve recovery. About 90 participants wi…

This study tests whether a home-use electrical stimulation device can safely improve leg muscle strength and physical performance in 40 older adults with sarcopenia (age-related muscle loss). Participants use the device on their thighs for 20 minutes, at least 4 times a week, for…

This study will test whether silkworm pupa powder, taken daily for 12 weeks, can improve memory, daily living skills, and frailty in 100 people with mild-to-moderate Alzheimer's disease. Participants will take the powder twice a day and visit the clinic every 4 weeks for tests in…

This study looks at whether taking magnesium supplements can improve muscle strength, muscle mass, and physical performance in older adults with sarcopenia (age-related muscle loss). Researchers will enroll 352 people aged 70 and older from Portugal. Participants with low magnesi…

This study tests whether silkworm pupa tablets can improve nutrition and reduce muscle loss (sarcopenia) in people who have completed cancer treatment. 480 participants will receive either the tablets or a placebo for 3 months. The main goal is to see if muscle strength and mass …

This study tests a 6-week program for adults 55 and older that combines group book discussions with simple mouth exercises. The goal is to see if it can reduce depression, improve physical and oral health, and boost mental toughness. Half of the 60 participants will do the progra…

This study tests whether personalized cooking and food guidance can help slow muscle loss in people with advanced cancer who are on chemotherapy. About 200 adults will be split into two groups: one gets standard nutrition care plus exercise advice, and the other gets the same plu…

This study tests whether an 8-week tele-rehabilitation program can improve muscle mass, reduce frailty, and enhance quality of life in adults with cystic fibrosis. Participants will do supervised exercise sessions at home via video calls three times a week. The goal is to see if …

This study tests whether a supervised exercise program can help women who have had breast or gynecological cancer and now suffer from muscle loss (sarcopenia). The 78 participants will do resistance, aerobic, balance, and stretching exercises. Researchers will measure changes in …

This study tests whether a digital prehabilitation app (HEAL-ME) combined with creatine and whey protein supplements can help maintain muscle health and reduce frailty in 100 adults with cirrhosis. Participants will use the app and take supplements for at least 3 months. The goal…

This study tests whether two types of amino acids (protein building blocks) can safely improve muscle mass and strength in 20 adults aged 45-75 with advanced chronic kidney disease and sarcopenia (muscle loss). Participants will take the supplements for 6 weeks while researchers …

This study tests two different supervised exercise programs in 350 adults aged 60 and older in Angola. One program includes strength, balance, and coordination exercises, while the other focuses on basic strengthening and daily activities. Both are done three times a week for 12 …

This study looks at whether a 12-week strengthening exercise program can improve muscle strength, muscle mass, and cognitive function in people with compensated liver cirrhosis. Twenty participants will be randomly assigned to either face-to-face or home-based exercise sessions t…

This study tests a home strengthening program using the BandPass system—a Bluetooth exercise band and mobile app that gives real-time feedback. Researchers want to see if older adults (65+) can use it easily and if it improves their strength and mobility. Participants will do a 1…

This study tests whether interactive video game exercises (exergames) can improve foot muscle activation, balance, and mobility in healthy older adults aged 65-80. Forty participants will be split into two groups: one doing exergame training and the other doing standard balance e…

This study tests whether a health informatics platform (with educational videos and instant messaging) plus resistance band exercises can improve quality of life and reduce muscle loss in 90 people who have had surgery for esophageal cancer. Participants will either receive the 1…

This study tests whether adding neuromuscular electrical stimulation (NMES) to resistance exercises can improve muscle strength and physical performance in hospitalized patients with alcoholic liver cirrhosis who have muscle loss (sarcopenia). About 112 participants aged 47–70 wi…

This study will examine muscle health in 533 adult survivors of childhood cancer and compare them to people without a cancer history. Using advanced imaging and tests, researchers hope to identify different types of muscle problems. The goal is to better understand why survivors …

This observational study will follow 200 women aged 45 to 60 to understand how muscle strength, bone density, body composition, physical activity, sleep, mood, and menopause symptoms relate to overall functional health. Participants will undergo simple strength tests, bone scans,…

This observational study will use bedside ultrasound to measure the diaphragm—the main breathing muscle—in 120 adults with liver cirrhosis and compare them to healthy volunteers. Researchers want to see if cirrhosis weakens the diaphragm and if removing fluid from the belly impro…

This study looks at whether a blood test measuring the ratio of two substances (IGF-1 and albumin) can help identify muscle loss (sarcopenia) in people with end-stage kidney disease on dialysis. Researchers will compare the test results to standard muscle assessments in 110 adult…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks at how sarcopenia (age-related muscle loss) is connected to fatigue and orthostatic intolerance (dizziness when standing up) in people aged 65 and older. Researchers will compare 90 older adults with and without sarcopenia to see if those with muscle loss experie…

This study will check how many people with knee osteoarthritis also have sarcopenia—a condition of low muscle mass and strength. Researchers in Upper Egypt will study 224 adults aged 40 and older to measure muscle health, nutrition, and quality of life. The goal is to better unde…

This study will compare 80 adults aged 40 and older—half living with HIV and half healthy—to see if those with HIV experience frailty, muscle loss, and cognitive decline earlier. Researchers will assess physical function, nutrition, and thinking skills. The goal is to understand …

This study looks at whether combining handgrip strength tests, body composition scans, and thigh ultrasound can better detect acute sarcopenia—a rapid loss of muscle mass and function—in older adults hospitalized for acute medical conditions. Researchers will follow 280 patients …

This study looks at whether a CT scan already done for routine care can predict which patients with leg artery disease will improve with supervised exercise therapy. About 40% of patients don't get enough benefit from exercise and need a procedure to open blocked arteries. Resear…

This study looks at 100 elderly patients with hip fractures to see if quick, easy tests like muscle ultrasound, handgrip strength, and routine blood work can predict frailty. Frailty affects recovery after surgery, so finding a fast way to measure it could help doctors provide sa…

This study will check how common sarcopenia (age-related muscle loss) is in 100 elderly people with type 2 diabetes. Researchers will use bedside muscle ultrasound and handgrip strength tests to measure muscle health, and a questionnaire to see how it affects quality of life. The…

This study looks at whether older adults (70+) with low muscle mass are more likely to have serious bleeding while taking common blood thinners (apixaban or rivaroxaban). Researchers will compare muscle mass in 110 patients who had a bleeding event with those who did not. The goa…