Could low muscle mass predict chemo toxicity in older cancer patients?

NCT ID NCT03998202

Recruiting now Knowledge-focused Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether low muscle mass (myopenia) is linked to severe side effects from chemotherapy in older adults with advanced colorectal cancer. Researchers will follow 300 newly diagnosed patients to track toxicities and survival. The goal is to better understand who might struggle with treatment, not to test a new drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors predict which older patients are at higher risk for severe chemotherapy side effects, leading to more personalized treatment plans.
What could go wrong: This is an observational study, not a treatment trial. It will not directly improve outcomes, and results may not apply to all patients or cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER SARCOPENIA

Contacts and locations

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Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Adena Regional Medical Center
RECRUITING

Chillicothe, Ohio, 45601, United States
Armes Family Cancer Center
RECRUITING

Findlay, Ohio, 45840, United States

Contact Email: •••••@•••••
Atrium Health Cabarrus/LCI-Concord
RECRUITING

Concord, North Carolina, 28025, United States
Atrium Health Pineville/LCI-Pineville
RECRUITING

Charlotte, North Carolina, 28210, United States
Atrium Health University City/LCI-University
RECRUITING

Charlotte, North Carolina, 28262, United States
BJC Outpatient Center at Sunset Hills
RECRUITING

Sunset Hills, Missouri, 63127, United States
Beebe Health Campus
RECRUITING

Rehoboth Beach, Delaware, 19971, United States

Contact Email: •••••@•••••
Beebe South Coastal Health Campus
RECRUITING

Millville, Delaware, 19967, United States

Contact Email: •••••@•••••
Broadlawns Medical Center
RECRUITING

Des Moines, Iowa, 50314, United States
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Hematology Centers - Flint
RECRUITING

Flint, Michigan, 48503, United States
Carle BroMenn Medical Center
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Cancer Institute Normal
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Physician Group - Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Carolinas Medical Center/Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28203, United States
Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Christiana Care Health System-Wilmington Hospital
RECRUITING

Wilmington, Delaware, 19801, United States
Community Medical Center
RECRUITING

Scranton, Pennsylvania, 18510, United States

Contact Email: •••••@•••••
Corewell Health Reed City Hospital
RECRUITING

Reed City, Michigan, 49677, United States
CoxHealth South Hospital
RECRUITING

Springfield, Missouri, 65807, United States
Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States
Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

Contact Email: •••••@•••••
Essentia Health - Park Rapids
RECRUITING

Park Rapids, Minnesota, 56470, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center-South University Clinic
RECRUITING

Fargo, North Dakota, 58103, United States

Contact Email: •••••@•••••
Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States
Essentia Health Saint Joseph's Medical Center
RECRUITING

Brainerd, Minnesota, 56401, United States

Contact Email: •••••@•••••
Essentia Health Saint Mary's - Detroit Lakes Clinic
RECRUITING

Detroit Lakes, Minnesota, 56501, United States

Contact Email: •••••@•••••
Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

Contact Email: •••••@•••••
Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

Contact Email: •••••@•••••
Essentia Health-Spooner Clinic
RECRUITING

Spooner, Wisconsin, 54801, United States

Contact Email: •••••@•••••
Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States
Geisinger Cancer Services-Pottsville
RECRUITING

Pottsville, Pennsylvania, 17901, United States

Contact Email: •••••@•••••
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

Contact Email: •••••@•••••
Geisinger Medical Center-Cancer Center Hazleton
RECRUITING

Hazleton, Pennsylvania, 18201, United States

Contact Email: •••••@•••••
Geisinger Medical Group
RECRUITING

State College, Pennsylvania, 16801, United States

Contact Email: •••••@•••••
Geisinger Medical Oncology-Lewisburg
RECRUITING

Lewisburg, Pennsylvania, 17837, United States

Contact Email: •••••@•••••
Geisinger Medical Oncology-Selinsgrove
RECRUITING

Selinsgrove, Pennsylvania, 17870, United States

Contact Email: •••••@•••••
Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

Contact Email: •••••@•••••
Genesee Hematology Oncology PC
RECRUITING

Flint, Michigan, 48503, United States
Genesis Healthcare System Cancer Care Center
RECRUITING

Zanesville, Ohio, 43701, United States
Genesys Hurley Cancer Institute
RECRUITING

Flint, Michigan, 48503, United States
Gibbs Cancer Center-Gaffney
RECRUITING

Gaffney, South Carolina, 29341, United States
Gibbs Cancer Center-Pelham
RECRUITING

Greer, South Carolina, 29651, United States
Health Partners Inc
WITHDRAWN

Minneapolis, Minnesota, 55454, United States
Heartland Regional Medical Center
RECRUITING

Saint Joseph, Missouri, 64506, United States
Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States
Illinois CancerCare - Washington
RECRUITING

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
RECRUITING

Canton, Illinois, 61520, United States
Illinois CancerCare-Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Ottawa Clinic
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
RECRUITING

Peru, Illinois, 61354, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
John B Amos Cancer Center
RECRUITING

Columbus, Georgia, 31904, United States
John H Stroger Jr Hospital of Cook County
RECRUITING

Chicago, Illinois, 60612, United States
Knox Community Hospital
RECRUITING

Mount Vernon, Ohio, 43050, United States
Levine Cancer Institute-Gaston
RECRUITING

Gastonia, North Carolina, 28054, United States
Levine Cancer Institute-SouthPark
RECRUITING

Charlotte, North Carolina, 28211, United States
Lewistown Hospital
RECRUITING

Lewistown, Pennsylvania, 17044, United States

Contact Email: •••••@•••••
Licking Memorial Hospital
RECRUITING

Newark, Ohio, 43055, United States
Louisiana Hematology Oncology Associates LLC
RECRUITING

Baton Rouge, Louisiana, 70809, United States

Contact Email: •••••@•••••
MBP Cancer Center - Baton Rouge General
RECRUITING

Baton Rouge, Louisiana, 70809, United States
MGC Hematology Oncology-Union
RECRUITING

Union, South Carolina, 29379, United States
Marshfield Medical Center - Minocqua
RECRUITING

Minocqua, Wisconsin, 54548, United States

Contact Email: •••••@•••••
Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

Contact Email: •••••@•••••
Marshfield Medical Center Dickinson
RECRUITING

Iron Mountain, Michigan, 49801, United States

Contact Email: •••••@•••••
Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

Contact Email: •••••@•••••
Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

Contact Email: •••••@•••••
Mary Bird Perkins Cancer Center
RECRUITING

Baton Rouge, Louisiana, 70809, United States

Contact Email: •••••@•••••
MedStar Georgetown University Hospital
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States
Mercy Clinic-Rolla-Cancer and Hematology
WITHDRAWN

Rolla, Missouri, 65401, United States
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Springfield
RECRUITING

Springfield, Missouri, 65804, United States
Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States

Contact Email: •••••@•••••
Minnesota Oncology Hematology PA-Maplewood
RECRUITING

Maplewood, Minnesota, 55109, United States
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital
RECRUITING

Sullivan, Missouri, 63080, United States
New Ulm Medical Center
RECRUITING

New Ulm, Minnesota, 56073, United States
Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Parkland Health Center - Farmington
RECRUITING

Farmington, Missouri, 63640, United States
Physicians' Clinic of Iowa PC
RECRUITING

Cedar Rapids, Iowa, 52402, United States
Prisma Health Cancer Institute - Butternut
RECRUITING

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley
RECRUITING

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside
RECRUITING

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris
RECRUITING

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer
RECRUITING

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca
RECRUITING

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg
RECRUITING

Boiling Springs, South Carolina, 29316, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital
RECRUITING

Willmar, Minnesota, 56201, United States
SIH Cancer Institute
RECRUITING

Carterville, Illinois, 62918, United States

Contact Email: •••••@•••••
SSM Health Good Samaritan
RECRUITING

Mount Vernon, Illinois, 62864, United States
Saint Anthony Regional Hospital
RECRUITING

Carroll, Iowa, 51401, United States
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Saint Francis Regional Medical Center
RECRUITING

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast
RECRUITING

Maplewood, Minnesota, 55109, United States
Saint Joseph Hospital East
WITHDRAWN

Lexington, Kentucky, 40509, United States
Saint Vincent Hospital Cancer Center Green Bay
RECRUITING

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
RECRUITING

Green Bay, Wisconsin, 54303, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
RECRUITING

Sturgeon Bay, Wisconsin, 54235-1495, United States
Sainte Genevieve County Memorial Hospital
RECRUITING

Sainte Genevieve, Missouri, 63670, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Email: •••••@•••••
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Self Regional Healthcare
WITHDRAWN

Greenwood, South Carolina, 29646, United States
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
Southern Ohio Medical Center
RECRUITING

Portsmouth, Ohio, 45662, United States
Spartanburg Medical Center
RECRUITING

Spartanburg, South Carolina, 29303, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Regional Cancer Center
RECRUITING

Springfield, Ohio, 45504, United States
Terrebonne General Medical Center
RECRUITING

Houma, Louisiana, 70360, United States
The Mark H Zangmeister Center
RECRUITING

Columbus, Ohio, 43219, United States
The University of Iowa - Ankeny
RECRUITING

Ankeny, Iowa, 50023, United States
The University of Iowa-Des Moines
RECRUITING

Des Moines, Iowa, 50309, United States
Trinity Health IHA Hematology Oncology Consultants-Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology -Ann Arbor
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health IHA Medical Group Hematology Oncology-Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health Medical Center-Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States

Contact Email: •••••@•••••
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States

Contact Email: •••••@•••••
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge
RECRUITING

Fort Dodge, Iowa, 50501, United States

Contact Email: •••••@•••••
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
University of Michigan Health - West
RECRUITING

Wyoming, Michigan, 49519, United States
Wake Forest Baptist Health - Wilkes Medical Center
RECRUITING

Wilkesboro, North Carolina, 28659, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Wake Forest University at Clemmons
RECRUITING

Clemmons, North Carolina, 27012, United States

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