Could longer or stronger antivirals beat COVID in vulnerable patients?
NCT ID NCT05587894
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether giving a longer course (10 days instead of 5) or adding another antiviral (remdesivir) to the standard Paxlovid treatment helps immunocompromised people clear COVID-19 faster. About 256 adults with mild or no symptoms will be randomly assigned to different treatment plans. The main goal is to see if the virus is gone by day 10.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Paxlovid (nirmatrelvir/ritonavir) and remdesivir
What this could lead to
If successful, this could show that a longer course or combination of antivirals helps immunocompromised people clear COVID-19 faster and avoid severe illness.
What could go wrong
This is a Phase 2 trial with only 256 participants, so results are preliminary. The added drugs may cause more side effects or not improve outcomes significantly.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Bichat Claude-Bernard Hospital
RECRUITINGParis, Paris, 75877, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Croix Rousse Hospital
RECRUITINGLyon, Lyon, 69317, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Division of Infectious Diseases, Verona University Hospital
RECRUITINGVerona, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Drammen Hospital, Vestre Viken Hospital
RECRUITINGDrammen, 3004, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Francois Mitterrand Hospital
RECRUITINGDijon, Dijon, 21079, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hotel Dieu Hospital
RECRUITINGNantes, Nantes, 44093, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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La Colombière Hospital
RECRUITINGMontpellier, Montpellier, 34295, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Laribosière Hospital
RECRUITINGParis, Paris, 75010, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oslo University Hospital and University of Oslo
RECRUITINGOslo, 0372, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Pellegrin Hospital
RECRUITINGBordeaux, Bordeaux, 33076, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Pitié-Salpêtrière Hospital
RECRUITINGParis, Paris, 75013, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Purpan Hospital
RECRUITINGToulouse, Toulouse, 31059, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Robert Debré Hospital
RECRUITINGReims, Reims, 51092, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Saint Antoine Hospital
RECRUITINGParis, Paris, 75012, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Saint Louis Hospital
RECRUITINGParis, Paris, 75474, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Saint-André Hospital
RECRUITINGBordeaux, Bordeaux, 33075, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tourcoing Hospital
RECRUITINGTourcoing, Tourcoing, 59208, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vestfold Hospital Trust
RECRUITINGTønsberg, 3103, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••