Could longer or stronger antivirals beat COVID in vulnerable patients?

NCT ID NCT05587894

Recruiting now Disease control Sponsor: ANRS, Emerging Infectious Diseases Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving a longer course (10 days instead of 5) or adding another antiviral (remdesivir) to the standard Paxlovid treatment helps immunocompromised people clear COVID-19 faster. About 256 adults with mild or no symptoms will be randomly assigned to different treatment plans. The main goal is to see if the virus is gone by day 10.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Paxlovid (nirmatrelvir/ritonavir) and remdesivir
What this could lead to: If successful, this could show that a longer course or combination of antivirals helps immunocompromised people clear COVID-19 faster and avoid severe illness.
What could go wrong: This is a Phase 2 trial with only 256 participants, so results are preliminary. The added drugs may cause more side effects or not improve outcomes significantly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

COVID-19 immunodeficiency disease inborn error of immunity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 IMMUNODEFICIENCY

Contacts and locations

Locations

Bichat Claude-Bernard Hospital
RECRUITING

Paris, Paris, 75877, France
Croix Rousse Hospital
RECRUITING

Lyon, Lyon, 69317, France
Division of Infectious Diseases, Verona University Hospital
RECRUITING

Verona, Italy
Drammen Hospital, Vestre Viken Hospital
RECRUITING

Drammen, 3004, Norway
Francois Mitterrand Hospital
RECRUITING

Dijon, Dijon, 21079, France
Hotel Dieu Hospital
RECRUITING

Nantes, Nantes, 44093, France
La Colombière Hospital
RECRUITING

Montpellier, Montpellier, 34295, France
Laribosière Hospital
RECRUITING

Paris, Paris, 75010, France
Oslo University Hospital and University of Oslo
RECRUITING

Oslo, 0372, Norway
Pellegrin Hospital
RECRUITING

Bordeaux, Bordeaux, 33076, France
Pitié-Salpêtrière Hospital
RECRUITING

Paris, Paris, 75013, France
Purpan Hospital
RECRUITING

Toulouse, Toulouse, 31059, France
Robert Debré Hospital
RECRUITING

Reims, Reims, 51092, France
Saint Antoine Hospital
RECRUITING

Paris, Paris, 75012, France
Saint Louis Hospital
RECRUITING

Paris, Paris, 75474, France
Saint-André Hospital
RECRUITING

Bordeaux, Bordeaux, 33075, France
Tourcoing Hospital
RECRUITING

Tourcoing, Tourcoing, 59208, France
Vestfold Hospital Trust
RECRUITING

Tønsberg, 3103, Norway

More trials for these conditions

Other studies related to the condition(s) this trial covers.