2,300 COVID survivors join quest to unravel long COVID mysteries
NCT ID NCT05531773
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study follows 2,300 adults who had COVID-19 to learn why some develop long-term symptoms like fatigue, brain fog, or organ damage. Researchers will review medical records and track participants over time. The goal is to find patterns and predictors of post-COVID condition, which could improve care and prevention.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors predict who will develop long COVID and identify ways to prevent or manage it.
- What could go wrong
- This is an observational study, not a treatment trial. It can show links but cannot prove causes, and results may not apply to all populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 2,300 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2022
- Expected to finish
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Dec 2025
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients diagnosed with acute COVID-19 disease from 01/03/2020 to 01/02/2025 at the participating centers will be enrolled in the study; two groups of patients recovered from acute COVID-19 will be enrolled: * Group 1 (hospitalized patients): patients hospitalized for COVID-19 disease; * Group 2 (outpatients): patients diagnosed with mild COVID-19 disease and thus not hospitalized (these patients will be referred to the Clinic of Infectious Diseases by the general practitioner or have received monoclonal antibodies for COVID-19 or antiviral treatments for COVID-19 at the Clinic of Infectious Diseases or have been visited at the Emergency Department of the hospital).
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients, \>18 years old; * Confirmed diagnosis of COVID-19 disease (positive SARS CoV-2 RNA on naso- pharyngeal swab or upper respiratory sample); * Mild COVID-19 disease without hospital admission or moderate/severe disease requiring hospital admission for COVID-19 or hospitalization for other medical issues with a positive SARS CoV-2 RNA sample; * Informed consent for the study. Exclusion Criteria: * death during hospitalization: * patient's decline to participate in the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
7 sites in 6 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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ASST Santi Paolo e Carlo
RECRUITINGMilan, Lombardy, Italy
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Centro Hospitalar de Lisboa Ocidental
RECRUITINGLisbon, Portugal
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Policlinico "Tor Vergata", Università degli Studi di Roma TOR VERGATA
RECRUITINGRome, Lazio, Italy
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Regional Hospital Dr. Juan Graham Casasús
RECRUITINGVillahermosa, Tabasco, Mexico
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St. Mary Hospital, Imperial College Healthcare NHS Trust
RECRUITINGLondon, United Kingdom
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University Hospital Heinrich Heine
RECRUITINGDüsseldorf, Germany
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Vilnius University Hospital, Santaros Klinikos
RECRUITINGVilnius, Lithuania
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