Can a Blood-Clot drug tame severe COVID-19?
NCT ID NCT04652115
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a drug called defibrotide is safe and feasible for people with severe COVID-19 pneumonia. About 42 adults with confirmed COVID-19 and lung infiltrates will receive the drug intravenously. Researchers will monitor for bleeding and low blood pressure as key safety concerns.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Defibrotide (given intravenously)
What this could lead to
If it works, this could point toward a new treatment to reduce complications in severe COVID-19 pneumonia.
What could go wrong
This is a small, early-phase safety study with only 42 participants, so it may not prove effectiveness. There are also risks of bleeding and low blood pressure.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brigham and Women's Hospital
RECRUITINGBoston, Massachusetts, 02214, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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