New pill combo aims to protect vulnerable from severe COVID

NCT ID NCT07013474

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This phase 3 trial tests a new antiviral pill, ibuzatrelvir, alone or with an IV drug (remdesivir) in 300 adults with weak immune systems who have mild-to-moderate COVID-19. The goal is to see if the combination prevents hospitalizations or worsening symptoms better than remdesivir alone. Participants are not severely ill at the start but are at high risk due to their immune status.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ibuzatrelvir (tablet) and remdesivir (injection)

What this could lead to

If successful, this could provide a new treatment option for severely immunocompromised people with COVID-19, potentially reducing hospitalizations and severe outcomes.

What could go wrong

This is still an experimental drug combination. The trial is relatively small (300 participants) and may not show a clear benefit over existing treatments. Side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Coronavinae infectious disease COVID-19 Infections lung disorder pneumonia respiratory tract infectious disorder RNA Virus Infections viral infectious disease viral pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 INFECTION

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AZ Sint-Jan Brugge-Oostende AV
RECRUITING

Bruges, West-vlaanderen, 8000, Belgium
Aalborg Universitetshospital, Syd
RECRUITING

Gistrup, 9260, Denmark
Aarhus Universitetshospital, Skejby
RECRUITING

Aarhus, Central Jutland, 8200, Denmark
Acibadem Universitesi Atakent Hastanesi
RECRUITING

Istanbul, İ̇stanbul, 34303, Turkey (Türkiye)
Alexandra General Hospital of Athens
RECRUITING

Athens, Attikí, 115 28, Greece
Amicis Research Center - Granada Hills
RECRUITING

Granada Hills, California, 91344, United States
Asan Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 05505, South Korea
Aso Iizuka Hospital
RECRUITING

Iizuka, Fukuoka, 820-8505, Japan
BRCR Global Puerto Rico
NOT_YET_RECRUITING

San Juan, 00907-1509, Puerto Rico
BRCR Medical Center - Ponce
NOT_YET_RECRUITING

Ponce, 00717, Puerto Rico
BRP- Hialeah Hospital
RECRUITING

Hialeah, Florida, 33013, United States
Baylor Scott & White Health - Center for Advanced Heart and Lung Disease
RECRUITING

Dallas, Texas, 75246, United States
Baylor Scott & White Research Institute - Clinical Trials Office
RECRUITING

Dallas, Texas, 75246, United States
Baylor University Medical Center
RECRUITING

Dallas, Texas, 75246, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
CECIP - Centro de Estudos do Interior Paulista
NOT_YET_RECRUITING

Jaú, São Paulo, 17201130, Brazil
CHUAC-Complejo Hospitalario Universitario A Coruña
RECRUITING

A Coruña, A Coruña [LA Coruña], 15006, Spain
CHUVI- Hospital Alvaro Cunqueiro
RECRUITING

Vigo, Pontevedra [pontevedra], 36212, Spain
Canas Medical Center
NOT_YET_RECRUITING

Ponce, 00728, Puerto Rico
Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand
RECRUITING

Dijon, 21000, France
Centro Médico São Francisco
RECRUITING

Curitiba, Paraná, 80810-050, Brazil
Chonnam National University Hospital
RECRUITING

Gwangju, Kwangju-kwangyǒkshi, 61469, South Korea
Clinical Trials Center
RECRUITING

Boston, Massachusetts, 02115, United States
Clinical Trials Hub
RECRUITING

Boston, Massachusetts, 02115, United States
D&H Cancer Research Center LLC
RECRUITING

Margate, Florida, 33063, United States
Duke University - Main Hospital and Clinics
RECRUITING

Durham, North Carolina, 27710, United States
Duke Vaccine and Trials Unit
RECRUITING

Durham, North Carolina, 27703, United States
Duke Vaccine and Trials Unit
RECRUITING

Durham, North Carolina, 27705, United States
Erasmus MC
RECRUITING

Rotterdam, 3015GD, Netherlands
Evangelismos General Hospital of Athens
RECRUITING

Athens, Attikí, 106 76, Greece
FAICIC S. de R.L. de C.V.
RECRUITING

Veracruz, Veracruz Ignacio de LA Llave, 91900, Mexico
Fakultna nemocnica Trnava
RECRUITING

Trnava, Trnava Region, 917 02, Slovakia
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica
RECRUITING

Banská Bystrica, Banská Bystrica Region, 974 01, Slovakia
Far Eastern Memorial Hospital
RECRUITING

New Taipei City, NEW Taipei, 220, Taiwan
Fujita Health University Hospital
RECRUITING

Toyoake, Aichi-ken, 470-1192, Japan
Fundación Santos y de la Garza Evia I.B.P
NOT_YET_RECRUITING

San Pedro Garza García, Nuevo León, 66278, Mexico
Gachon University Gil Medical Center
RECRUITING

Namdong-gu, Incheon-gwangyeoksi [incheon], 21565, South Korea
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
RECRUITING

Gaziantep, 27310, Turkey (Türkiye)
General Hospital of Athens "Laiko"
RECRUITING

Athens, Attikí, 11527, Greece
Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Hacettepe Universite Hastaneleri
RECRUITING

Ankara, 06230, Turkey (Türkiye)
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Holy Name Medical Center
RECRUITING

Teaneck, New Jersey, 07666, United States
Hope Clinical Research, Inc.
RECRUITING

Canoga Park, California, 91303, United States
Hopital Claude Huriez - CHU de Lille
RECRUITING

Lille, NORD, 59037, France
Hospital General Universitario Dr. Balmis
RECRUITING

Alicante, 03010, Spain
Hospital Germans Trias i Pujol
RECRUITING

Badalona, Barcelona [barcelona], 08916, Spain
Hospital Italiano de Buenos Aires
RECRUITING

ABB, Buenos Aires F.D., C1199ABB, Argentina
Hospital Italiano de La Plata
RECRUITING

La Plata, Buenos Aires, B1900XI, Argentina
Hospital Nossa Senhora das Graças
RECRUITING

Curitiba, Paraná, 80810-040, Brazil
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona [barcelona], 08035, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, Madrid, Comunidad de, 28046, Spain
Hospital Universitario Reina Sofia
RECRUITING

Córdoba, Andalusia, 14004, Spain
Hospital Universitario Virgen de Valme
RECRUITING

Seville, 41014, Spain
Hospital de Clinicas de Porto Alegre
RECRUITING

Bairro Santa Cecília, Rio Grande do Sul, 90630-165, Brazil
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, Catalunya [cataluña], 08041, Spain
Hospital e Maternidade Celso Pierro
NOT_YET_RECRUITING

Campinas, São Paulo, 13060-803, Brazil
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Humphreys Diabetes Center
RECRUITING

Boise, Idaho, 83702, United States
Hôpital Bichat - Claude-Bernard
RECRUITING

Paris, 75018, France
Hôpital Saint Antoine
RECRUITING

Paris, 75012, France
Hôpital Saint-Louis
RECRUITING

Paris, Île-de-France Region, 75010, France
Ibni Sina Hospital
RECRUITING

Ankara, 06230, Turkey (Türkiye)
Icesp - Instituto Do Câncer Do Estado de São Paulo
RECRUITING

São Paulo, 01246-000, Brazil
Instituto Médico Río Cuarto
RECRUITING

Río Cuarto, Córdoba Province, X5800AEV, Argentina
Instituto Nacional de Infectologia Evandro Chagas
NOT_YET_RECRUITING

Rio de Janeiro, 21040-360, Brazil
International University of Health and Welfare Narita Hospital
RECRUITING

Narita, Chiba, 286-8520, Japan
Ippokrateio General Hospital of Thessaloniki
NOT_YET_RECRUITING

Thessaloniki, 546 42, Greece
Jacobs Medical Center at UC San Diego Health
RECRUITING

La Jolla, California, 92037, United States
Jadestone Clinical Research
RECRUITING

Silver Spring, Maryland, 20904, United States
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
Jules Bordet Institute
RECRUITING

Anderlecht, 1070, Belgium
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Karadeniz Technical University
RECRUITING

Trabzon, 61080, Turkey (Türkiye)
Karolinska Universitetssjukhuset Huddinge
RECRUITING

Huddinge, 141 86, Sweden
Kendall South Medical Center
RECRUITING

Miami, Florida, 33185, United States
Kocaeli Üniversitesi
RECRUITING

Kocaeli, 41380, Turkey (Türkiye)
Medical University of South Carolina
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
Medical University of South Carolina Infectious Disease Clinic
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
Medical University of South Carolina Investigational Drug Services (IDS)
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
Medical University of South Carolina Investigational Drug Services Pharmacy
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
Medical University of South Carolina Research Nexus Clinic
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
Medical University of South Carolina Translational Research Nexus Clinic and Laboratory
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Hermann Hospital
RECRUITING

Houston, Texas, 77030, United States
Nagasaki University Hospital
RECRUITING

Nagasaki, 852-8501, Japan
Narodny onkologicky ustav
RECRUITING

Bratislava, 833 10, Slovakia
Narodny ustav detskych chorob
RECRUITING

Bratislava, Bratislava Region, 833 40, Slovakia
National Center for Global Health and Medicine
RECRUITING

Shinjuku, Tokyo, 162-8655, Japan
National Hospital Organization Kyushu Medical Center
RECRUITING

Fukuoka, 810-8563, Japan
Nemocnica s poliklinikou Stefana Kukuru Michalovce, a.s.
RECRUITING

Michalovce, 07101, Slovakia
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Northwestern University Feinberg School of Medicine
RECRUITING

Chicago, Illinois, 60611, United States
Odense Universitetshospital
RECRUITING

Odense, Region Syddanmark, 5000, Denmark
Parc de Salut Mar - Hospital del Mar
RECRUITING

Barcelona, Barcelona [barcelona], 08003, Spain
Profound Research LLC
RECRUITING

Farmington Hills, Michigan, 48334, United States
Radboudumc
NOT_YET_RECRUITING

Nijmegen, 6525 GA, Netherlands
Rigshospitalet
RECRUITING

Copenhagen, Capital Region, 2100, Denmark
Rinku General Medical Center
RECRUITING

Izumisano, Osaka, 598-8577, Japan
Saga University Hospital
RECRUITING

Saga, 849-8501, Japan
Sakarya Training and Research Hospital
RECRUITING

Sakarya, 54100, Turkey (Türkiye)
Sanatorio Sagrado Corazón
RECRUITING

Buenos Aires, 1039, Argentina
School of Medicine Federal University of Minas Gerais
RECRUITING

Belo Horizonte, Minas Gerais, 30130-100, Brazil
Seattle Rheumatology Associates
RECRUITING

Seattle, Washington, 98104, United States
Skylight Health Research, - Burlington
RECRUITING

Burlington, Massachusetts, 01803, United States
Skånes Universitetssjukhus Malmö
RECRUITING

Malmö, Skåne LÄN [se-12], 205 02, Sweden
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
NOT_YET_RECRUITING

São Paulo, 05652-900, Brazil
St. Luke's Idaho Elks Children's Pavilion
RECRUITING

Boise, Idaho, 83712, United States
Swedish Ambulatory Infusion Center- First Hill
RECRUITING

Seattle, Washington, 98104, United States
Swedish Cancer Institute Treatment Center
RECRUITING

Seattle, Washington, 98104, United States
Swedish Medical Center - First Hill Campus
RECRUITING

Seattle, Washington, 98122, United States
Swedish Medical Center- Innovative Therapeutics & Research Unit
RECRUITING

Seattle, Washington, 98104, United States
Swedish Organ Transplant and Liver Center
RECRUITING

Seattle, Washington, 98104, United States
TRC
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
TUM Klinikum
RECRUITING

München, Bavaria, 81675, Germany
Tachikawa Hospital
RECRUITING

Tachikawa, Tokyo, 190-8531, Japan
Taichung Veterans General Hospital
RECRUITING

Taichung, 407, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 03312, South Korea
The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States
Tokyo Medical University Hachioji Medical Center
RECRUITING

Hachiōji, Tokyo, 1930998, Japan
UC Davis CTSC Clinical Research Center
RECRUITING

Sacramento, California, 95817, United States
UC San Diego Medical Center - Hillcrest
RECRUITING

San Diego, California, 92103, United States
UCHealth Anschutz Inpatient Pavilion - Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
UKE Hamburg
RECRUITING

Hamburg, 20246, Germany
UPMC Division of Infectious Disease Clinic
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UPMC Presbyterian IDS
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UPMC Presbyterian Shadyside
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UPMC Shadyside
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UPMC Shadyside IDS
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UT Physicians
RECRUITING

Houston, Texas, 77030, United States
UZ Brussel
RECRUITING

Brussels, Brussels Capital, 1090, Belgium
Universitaetsklinikum Koeln
RECRUITING

Cologne, North Rhine-Westphalia, 50937, Germany
University General Hospital of Alexandroupoli
RECRUITING

Alexandroupoli, Anatolikí Makedonía KAI Thráki, 681 00, Greece
University of California Davis Health
RECRUITING

Sacramento, California, 95817, United States
University of California San Diego Health
RECRUITING

San Diego, California, 92103, United States
University of Cincinnati College of Medicine (UC Holmes)
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Colorado Clinical and Translational Research Center
RECRUITING

Aurora, Colorado, 80045, United States
University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
University of Massachusetts Chan Medical School
RECRUITING

Worcester, Massachusetts, 01655, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Université Libre de Bruxelles - Hôpital Erasme
RECRUITING

Brussels, Bruxelles-capitale, Région de, 1070, Belgium
Velocity Clinical Research, Savannah
RECRUITING

Savannah, Georgia, 31406, United States
West Tennessee Research Institute
RECRUITING

Jackson, Tennessee, 38305, United States
Zenos Clinical Research
RECRUITING

Dallas, Texas, 75230, United States