Can pressurized oxygen clear long COVID brain fog?
NCT ID NCT04647656
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can improve thinking, memory, and other symptoms in people with long COVID. About 91 adults who have had cognitive problems for at least 3 months after a COVID infection will be randomly assigned to receive either real hyperbaric oxygen or a sham (fake) treatment. The goal is to see if this therapy can help with brain function and related issues like fatigue and sleep problems.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber)
What this could lead to
If it works, this could offer a new treatment option for people struggling with brain fog, fatigue, and other lingering symptoms after COVID-19.
What could go wrong
This is a relatively small, early-stage study (91 people) and the sham group also receives mild pressure, so the real benefit may be small or unclear. Hyperbaric oxygen can cause ear or sinus discomfort in some people.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Assaf-Harofeh medical center
RECRUITINGẔerifin, 70300, Israel
Contact Phone: •••-•••-•••• Email: •••••@•••••