New vaccine aims to supercharge COVID-19 immunity

NCT ID NCT06810934

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: Kara Chew Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing two experimental COVID-19 booster vaccines in 80 healthy volunteers aged 40-64. One vaccine includes an extra component called 's3' designed to improve the body's immune response. Participants will receive a single dose of either vaccine or a placebo and be monitored for side effects and immune responses. The goal is to see if these vaccines are safe and if the s3 component leads to broader, longer-lasting protection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ad35-vectored SARS-CoV-2 RBD (XBB.1.5) vaccine
What this could lead to: If successful, this could lead to a more effective COVID-19 booster that provides broader and longer-lasting protection against current and future variants.
What could go wrong: This is an early-phase trial with only 80 participants, so results may not apply to the general population. The vaccine may not produce stronger immunity than existing boosters, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for COVID-19 are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Coronavinae infectious disease Infections RNA Virus Infections viral infectious disease COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 SARS-COV-2 INFECTION

Contacts and locations

Locations

UCLA Westwood
RECRUITING

Los Angeles, California, 90095, United States
UCSF Community and Clinical Research Center
RECRUITING

San Francisco, California, 94110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.