New COVID pill shows promise in early trial

NCT ID NCT06928051

Completed Disease control Sponsor: Shionogi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 2 study tested an oral antiviral drug called S-892216 in 282 adults with mild-to-moderate COVID-19. Participants took either the drug or a placebo tablet for a short time. The main goal was to see if the drug could lower the amount of virus in the nose and throat by day 4. Researchers also tracked how quickly symptoms improved and when the virus became undetectable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: S-892216 (oral antiviral tablet)
What this could lead to: If successful, this could provide a new oral treatment option for mild-to-moderate COVID-19, helping reduce viral levels and speed recovery.
What could go wrong: This is a Phase 2 trial with 282 participants, so results are still early. The drug may not show a strong enough antiviral effect or could have side effects not yet fully understood.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19

Contacts and locations

Locations

Advanced Research for Health Improvement LLC

Immokalee, Florida, 34142, United States
Alina Clinical Trials LLC

Dallas, Texas, 75209, United States
Balanced Life Health Care Solutions

Lawrenceville, Georgia, 30046, United States
CCM Clinical Research Group

Miami, Florida, 33133, United States
Care United Research, LLC

Forney, Texas, 75126, United States
Clinical Research Partners LLC

Richmond, Virginia, 23226, United States
Combined Research Orlando Phase I-IV LLC

Orlando, Florida, 32807, United States
Continental Clinical Research

Miami, Florida, 33144, United States
Entrust Clinical Research

Miami, Florida, 33176, United States
Frontier Clinical Research LLC

Kingwood, West Virginia, 26537, United States
Global Clinical Professionals

St. Petersburg, Florida, 33705, United States
Global Health Clinical Trials

Miami, Florida, 33135, United States
Healthstar Research

Hot Springs, Arkansas, 71913, United States
Hope Clinical Trials

Coral Gables, Florida, 33134, United States
Invictus Clinical Research Group LLC

Coconut Creek, Florida, 33073, United States
Japanese Site 1

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Kendall South Medical Center Inc

Miami, Florida, 33185, United States
LCC Medical Research

Miami, Florida, 33126, United States
Oceane7 Medical & Research Center, Inc.

Miami Lakes, Florida, 33144, United States
Palm Springs Community Health Center

Miami Lakes, Florida, 33014, United States
PanAmerican Clincal Research

Brownsville, Texas, 78520, United States
Quality Research of South Florida

Miami Lakes, Florida, 33016, United States

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