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Why does dengue put some people in the hospital? scientists track 258 patients to find out
NCT ID NCT05607472
First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time
Summary
Dengue has become a recurring illness on Reunion Island, and repeat infections tend to be more severe. Researchers are following 258 adults and children who arrive at two island hospitals with confirmed or suspected dengue, collecting blood samples and health questionnaires over 18 months. The goal is to identify which factors at first consultation predict hospitalization and severe disease, and to understand how patients recover over the long term.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If researchers identify which factors predict severe dengue, doctors could triage high-risk patients sooner and target care where it matters most.
- What could go wrong
- This is an observational study, so it can show links between factors and outcomes but cannot prove cause and effect. Findings from one island population may not apply elsewhere.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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258 people
The number who actually took part.
- Started
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Mar 2022
- Finished
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Dec 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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8 months and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Adult patients (including pregnant women) or children (\> 8 kg) * Admitted to the Emergency Department, in the hospital wards, or in outpatient clinics from the two teaching hospitals of Réunion island * with a definite or probable diagnosis of dengue, as defined by a positive PCR (plasma or urine), NS1 antigen within the first five days of onset of symptoms; or 2 serologies indicating a recent primary or a secondary infection (positive IgM twice or IgG seroconversion x 4 at a minimum of 10 days apart) * affiliated to a social insurance Exclusion Criteria: * refusal of participation as expressed by the patient or its entourage (if the patient is physically unable to give his opinion) * absence of social insurance
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Patrick GERARDIN
Saint-Pierre, 97410, France
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Other studies related to the condition(s) this trial covers.
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