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Can detailed tracking of dengue patients sharpen the next generation of clinical trials?

NCT ID NCT07799168

Knowledge-focused Sponsor: Liverpool School of Tropical Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This observational study follows 235 people hospitalised with dengue in Vietnam to map how the illness unfolds, especially the leaking of blood vessels that can lead to severe disease. Researchers will collect routine clinical data, blood samples, and ultrasound scans during the hospital stay, plus a follow-up visit. The goal is to develop new statistical models that describe dengue accurately and to identify blood biomarkers that could serve as reliable measures of severity and recovery in future treatment trials. The study also checks whether simplified diagnostic tests match laboratory reference methods for use in low- and middle-income countries.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could improve how future dengue trials are designed, making them more accurate and efficient, and could identify simple blood tests to track disease severity.
What could go wrong
This is an observational study, so it does not test a treatment. The findings may not apply to other regions or patient groups, and the new statistical methods and biomarkers need further validation before they can be used in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 235 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients presenting to Khánh Hòa Hospital of Tropical Diseases, Nha Trang, Vietnam.

Ages

16 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (hospitalised cohort): * Meet the 2009 WHO criteria for dengue with warning signs or severe dengue AND * Are being admitted as an inpatient AND * Have documented standard-of-care laboratory confirmation of dengue (defined as either positive by molecular assay (e.g. reverse transcription polymerase chain reaction) OR positive by antigen testing (non-structural protein-1) OR positive Immunoglobulin M (IgM) combined with clinical diagnosis of dengue by attending physician. AND * Were born in Vietnam (only for platelet phenomics substudy) Inclusion Criteria (diagnostic control cohort): * Have a documented fever at assessment AND * Have a documented negative standard-of-care dengue test, with no clinical diagnosis of dengue AND * Were born in Vietnam (only for platelet phenomics substudy) Inclusion Criteria (platelet control cohort): * Vietnamese-born adults ≥16 years of age with no history of febrile illness in the preceding 14 days. Exclusion Criteria: * Receiving an experimental dengue treatment during their illness. * Inability to provide written, informed consent AND no legal guardian able to provide written, informed consent in the event of incapacity. * Clinician-determined unsuitability for recruitment. Exclusion Criteria (platelet substudy only): * Any non-steroidal anti-inflammatory, antiplatelet or anticoagulant medication received in preceding 7 days.

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Conditions

The condition(s) this trial relates to.

dengue disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dengue

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Nagasaki University Vietnam Research Station, Nha Trang

    Nha Trang, Vietnam

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