Old HIV drugs get a second look in Long-Term study
NCT ID NCT01125228
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This study compares three treatments for early HIV infection: zidovudine (AZT) alone, alpha-interferon alone, or both together. It aims to see which best lowers viral load, protects the immune system, and delays the first serious infection. About 180 adults with early HIV and healthy immune systems are taking part, with long-term follow-up to track outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
zidovudine (AZT) and alpha-interferon
What this could lead to
If successful, this could show which early HIV treatment better controls the virus and delays opportunistic infections.
What could go wrong
This is an older study from before modern HIV treatments (HAART), so results may not apply to current care. Side effects from both drugs can be significant.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States