Virus therapy takes on liver cancer in major trial

NCT ID NCT02562755

Completed Disease control Sponsor: SillaJen, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a virus-based immunotherapy (Pexa-Vec) to the standard drug sorafenib helps people with advanced liver cancer live longer. About 459 adults with advanced liver cancer who had not received prior treatment took part. The approach uses a modified virus to attack cancer cells and boost the immune system, followed by sorafenib to slow tumor growth.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma neoplasm vaccinia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOCELLULAR CARCINOMA (HCC)

Contacts and locations

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Locations

Auckland City Hospital

Auckland, New Zealand, 1142, New Zealand
Benaroya Research Institute at Virginia Mason Hospital

Seattle, Washington, 98101, United States
Billings Clinic

Billings, Montana, 59101, United States
Hospital of The University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Juravinski Cancer Centre

Hamilton, Ontario, L8V 1C3, Canada
Kansas City Research Institute

Kansas City, Missouri, 64131, United States
Mayo Clinic Arizona

Scottsdale, Arizona, 85259, United States
Mercy Medical Center, Inc.

Baltimore, Maryland, 21202, United States
Morristown Medical Center

Morristown, New Jersey, 07960, United States
Ohio State University

Columbus, Ohio, 43210, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Saint Louis University

St Louis, Missouri, 63104, United States
Site 8216

Daegu, South Korea
Site 8224

Goyang, South Korea
Site 8702

Singapore, Singapore
Site 8703

Singapore, Singapore
Site 8805

Hefei, China
Site 8806

Shanghai, China
Site 8811

Fuzhou, China
Site 8820

Fuzhou, China
Site 8822

Shanghai, China
Site 8827

Guangzhou, China
Site 8829

Changchun, China
Site 8831

Shanghai, China
Site 8832

Hangzhou, China
Site 8833

Qingdao, China
Site 9012

Montpellier, France
Site 9704

Haifa, Israel
Site No 9105

Hannover, Germany
Site No. 8201

Busan, South Korea
Site No. 8202

Seoul, South Korea
Site No. 8203

Seoul, South Korea
Site No. 8205

Seoul, South Korea
Site No. 8207

Daegu, South Korea
Site No. 8208

Ansan, South Korea
Site No. 8209

Seoul, South Korea
Site No. 8210

Suwon, South Korea
Site No. 8211

Bucheon-si, South Korea
Site No. 8212

Seoul, South Korea
Site No. 8213

Daegu, South Korea
Site No. 8215

Seoul, South Korea
Site No. 8217

Ulsan, South Korea
Site No. 8218

Pusan, South Korea
Site No. 8219

Seongnam-si, South Korea
Site No. 8220

Daegu, South Korea
Site No. 8221

Jinju, South Korea
Site No. 8222

Seongnam, South Korea
Site No. 8223

Seoul, South Korea
Site No. 8301

Taipei, Taiwan
Site No. 8302

Tainan, Taiwan
Site No. 8303

Taipei, Taiwan
Site No. 8305

Kaohsiung City, Taiwan
Site No. 8306

Taichung, Taiwan
Site No. 8307

Linkou District, Taiwan
Site No. 8401

Camperdown, Australia
Site No. 8402

Parkville, Australia
Site No. 8403

Brisbane, Australia
Site No. 8405

Footscray, Australia
Site No. 8406

Concord, Australia
Site No. 8407

Clayton, Australia
Site No. 8408

Fitzroy, Australia
Site No. 8409

Adelaide, Australia
Site No. 8411

Melbourne, Australia
Site No. 8412

Adelaide, Australia
Site No. 8413

Sydney, Australia
Site No. 8414

Heidelberg, Australia
Site No. 8415

Perth, Australia
Site No. 8501

Khon Kaen, Thailand
Site No. 8502

Bangkok, Thailand
Site No. 8503

Chiang Mai, Thailand
Site No. 8505

Bangkok, Thailand
Site No. 8506

Phitsanulok, Thailand
Site No. 8507

Hat Yai, Thailand
Site No. 8601

Hong Kong, Hong Kong
Site No. 8701

Singapore, Singapore
Site No. 8801

Nanjing, China
Site No. 8802

Harbin, China
Site No. 8808

Hefei, China
Site No. 8821

Changsha, China
Site No. 8823

Xi'an, China
Site No. 8825

Xi'an, China
Site No. 8902

Christchurch, New Zealand
Site No. 9001

Strasbourg, France
Site No. 9002

Toulouse, France
Site No. 9003

Créteil, France
Site No. 9005

Bordeaux, France
Site No. 9006

Lille, France
Site No. 9007

Paris, France
Site No. 9008

Nantes, France
Site No. 9009

Vandœuvre-lès-Nancy, France
Site No. 9010

Nice, France
Site No. 9011

Rennes, France
Site No. 9013

Bondy, France
Site No. 9014

Paris, France
Site No. 9101

Mainz, Germany
Site No. 9102

München, Germany
Site No. 9104

Tübingen, Germany
Site No. 9106

Hamburg, Germany
Site No. 9108

Frankfurt am Main, Germany
Site No. 9109

Dresden, Germany
Site No. 9110

Ulm, Germany
Site No. 9111

Aachen, Germany
Site No. 9112

Heidelberg, Germany
Site No. 9113

Bonn, Germany
Site No. 9201

Palermo, Italy
Site No. 9203

Parma, Italy
Site No. 9204

Naples, Italy
Site No. 9401

Porto, Portugal
Site No. 9402

Porto, Portugal
Site No. 9403

Lisbon, Portugal
Site No. 9404

Coimbra, Portugal
Site No. 9405

Coimbra, Portugal
Site No. 9501

Birmingham, United Kingdom
Site No. 9502

London, United Kingdom
Site No. 9503

Leeds, United Kingdom
Site No. 9504

London, United Kingdom
Site No. 9505

Guildford, United Kingdom
Site No. 9506

London, United Kingdom
Site No. 9702

Haifa, Israel
Site No. 9703

Ramat Gan, Israel
Site No. 9705

Jerusalem, Israel
Site No. 9706

Tel Aviv, Israel
Site No. 9707

Afula, Israel
Site No.8815

Hefei, China
Site No.8816

Guangdong, China
Site No.8828

Guangzhou, China
Site No.9205

Modena, Italy
St. Joseph's Hospital

Paterson, New Jersey, 07503, United States
Stanford University School of Medicine

Palo Alto, California, 94304, United States
Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada
Tulane University Health Sciences Center

New Orleans, Louisiana, 70112, United States
UC Irvine Medical Center

Orange, California, 92868, United States
University of Alabama

Birmingham, Alabama, 35294, United States
University of Alberta Hospital

Edmonton, Alberta, T6G 2B7, Canada
University of Chicago

Chicago, Illinois, 60637, United States
University of Florida Shands Hospital

Gainesville, Florida, 32608, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66205, United States
University of Louisville

Louisville, Kentucky, 40202, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Tennessee Medical Center

Knoxville, Tennessee, 37920, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States