Can a diabetes drug help fight liver cancer? a trial puts it to the test

NCT ID NCT07729592

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial investigates whether adding dapagliflozin—a drug typically used for diabetes—to standard first-line therapy can improve tumor response in people with advanced liver cancer that cannot be surgically removed and who also have metabolic syndrome. About 44 participants will receive either the standard therapy alone or standard therapy plus dapagliflozin. Researchers will compare how well the tumors shrink and how long patients live or go without the cancer worsening.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
dapagliflozin added to standard therapy (donafenib and tislelizumab)
What this could lead to
If successful, adding dapagliflozin could boost tumor shrinkage rates for people with advanced liver cancer and metabolic syndrome, offering a new combination approach.
What could go wrong
This is a small, early-phase trial (44 participants) at a single center, so results may not apply broadly. Dapagliflozin may also cause side effects like dehydration or urinary infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

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