Can a diabetes drug help fight liver cancer? a trial puts it to the test
NCT ID NCT07729592
First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time
Summary
This trial investigates whether adding dapagliflozin—a drug typically used for diabetes—to standard first-line therapy can improve tumor response in people with advanced liver cancer that cannot be surgically removed and who also have metabolic syndrome. About 44 participants will receive either the standard therapy alone or standard therapy plus dapagliflozin. Researchers will compare how well the tumors shrink and how long patients live or go without the cancer worsening.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- dapagliflozin added to standard therapy (donafenib and tislelizumab)
- What this could lead to
- If successful, adding dapagliflozin could boost tumor shrinkage rates for people with advanced liver cancer and metabolic syndrome, offering a new combination approach.
- What could go wrong
- This is a small, early-phase trial (44 participants) at a single center, so results may not apply broadly. Dapagliflozin may also cause side effects like dehydration or urinary infections.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEPATOCELLULAR CARCINOMA (HCC) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a 'No-Touch' microwave technique match surgery for liver tumors?
- Can blood tests reveal how liver and bile duct cancers respond to treatment?
- AI-Powered surveillance may outsmart liver cancer recurrence
- Blood markers may forecast liver cancer treatment success
- Can a triple therapy shrink untreatable liver tumors?
- Breath of life: new test could sniff out gut cancers before they spread