Can a pill and a vaccine stop STIs in High-Risk men?
NCT ID NCT04597424
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two strategies to prevent sexually transmitted infections (STIs) in men who have sex with men and already take HIV PrEP. One group took doxycycline pills after unprotected sex, and another group received a meningitis vaccine (Bexsero). The goal was to see if these approaches could reduce new cases of chlamydia, syphilis, and gonorrhea. Over 550 men took part in this completed Phase 3 trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
doxycycline and Bexsero® vaccine
What this could lead to
If it works, this could offer a new way to prevent bacterial STIs in high-risk groups, reducing infections like chlamydia, syphilis, and gonorrhea.
What could go wrong
This is a completed Phase 3 trial, but results may not apply to all populations. Doxycycline overuse could lead to antibiotic resistance, and the vaccine may not protect against all gonorrhea strains.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hôpital Bichat
Paris, 75000, France
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Hôpital Européen Georges Pompidou
Paris, 75908, France
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Hôpital Hôtel Dieu
Paris, 75181, France
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Hôpital Necker-Enfants Malades
Paris, 75743, France
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Hôpital Pitié-Salpétrière
Paris, 75651, France
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Hôpital Saint-Antoine
Paris, 75571, France
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Hôpital Saint-Louis
Paris, 75475, France
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Hôpital Tenon
Paris, 75970, France
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Hôpital pitié Salpetrière
Paris, 75651, France