One shot, two protections? new study combines e. coli and flu vaccines for seniors
NCT ID NCT06134804
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a new vaccine against certain E. coli bacteria (ExPEC9V) can be given at the same time as a high-dose flu shot in adults aged 65 and older. The goal was to see if the immune response to both vaccines remains strong when given together. About 959 participants took part, and the study looked at antibody levels 29 days after vaccination.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ExPEC9V (a vaccine against certain types of E. coli bacteria) and high-dose quadrivalent influenza vaccine
What this could lead to
If successful, this could show that older adults can get protection against both severe E. coli infections and flu with a single visit, simplifying vaccination schedules.
What could go wrong
This is a completed phase 3 trial focused on immune response, not on directly proving the vaccine prevents disease. The results may not guarantee real-world effectiveness.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Accellacare
Wilmington, North Carolina, 28401, United States
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Aggarwal and associates Ltd
Brampton, Ontario, L6T 0G1, Canada
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Alliance for Multispeciality Research
Mobile, Alabama, 36608, United States
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Alliance for Multispeciality Research
Lexington, Kentucky, 40509, United States
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Alliance for Multispeciality Research
Knoxville, Tennessee, 37909, United States
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Artemis Institute for Clinical Research
San Diego, California, 92103, United States
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Atlanta Center for Medical Research
Atlanta, Georgia, 30331, United States
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Az Sint-Maarten
Mechelen, 2800, Belgium
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Benchmark Clinical Research - Austin
Austin, Texas, 78705, United States
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CTI Clinical Trial and Consulting Services
Cincinnati, Ohio, 45212, United States
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Center for Vaccinology (CEVAC)
Ghent, 9000, Belgium
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Centricity Research- Manna Research (MR) - Quebec Location
Lévis, Quebec, G6W 0M5, Canada
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Diablo Clinical Research, Inc.
Walnut Creek, California, 94598, United States
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Heartland Research Associates, LLC
Newton, Kansas, 67114, United States
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Heartland Research Associates, an AMR Company
Wichita, Kansas, 67207, United States
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MICS Centrum Medyczne Torun
Torun, 87-100, Poland
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MICS Centrum Medyczne Warszawa
Warsaw, 00 874, Poland
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Medical Affiliated Research Center Inc. (MARC)
Huntsville, Alabama, 35801, United States
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Milestone Research
London, Ontario, N5W 6A2, Canada
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Optimal Research
Melbourne, Florida, 32934, United States
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Optimal Research
Peoria, Illinois, 61614, United States
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Optimal Research
Austin, Texas, 78744, United States
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PUNKT ZDROWIA Hlebowicz Jakubowski Lekarze sp.p.
Gdansk, 80405, Poland
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Pharmax Research Clinic Inc
Miami, Florida, 33126, United States
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Pratia MCM Krakow
Krakow, 30 727, Poland
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Suncoast Research Associates, LLC
Miami, Florida, 33173, United States
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Synexus Clinical Research US Inc
Chicago, Illinois, 60602, United States
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Synexus Clinical Research US Inc
Creve Coeur, Missouri, 63141, United States
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Synexus Polska Sp z o o Oddzial w Katowicach
Katowice, 40 040, Poland
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Synexus Polska Sp z o o Oddzial w Warszawie
Warsaw, 02 672, Poland
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Synexus Polska Sp z o o Oddzial we Wroclawiu
Wroclaw, 50 381, Poland
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Synexus Polska Sp. z o.o. Oddzial w Gdansku
Gdansk, 80 382, Poland
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Synexus Polska Sp. z o.o. Oddzial w Gdynia
Gdynia, 81 537, Poland
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Synexus Radiant Research, Inc
Evansville, Indiana, 47714, United States
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Tekton Research Inc.
Beaumont, Texas, 77706, United States
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Universiteit Antwerpen - Centrum voor de Evaluatie van Vaccinaties (CEV)
Edegem, 2650, Belgium
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Velocity Clinical Research
Savannah, Georgia, 31406, United States
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Velocity Clinical Research
Cleveland, Ohio, 44122, United States
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Velocity Clinical Research
East Greenwich, Rhode Island, 02818, United States
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Velocity Lublin
Lublin, 20 362, Poland
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Velocity Staszow
Staszów, 28 200, Poland