Common cold

This study tests whether a daily pill called AP1189 can help hospitalized patients with breathing failure due to viruses like flu, RSV, or COVID-19. About 96 adults will receive either AP1189 or a placebo for 14 days, on top of usual care. The main goal is to see if the drug redu…

This trial investigates whether a rapid C-reactive protein (CRP) blood test can help doctors decide when antibiotics are truly needed for adults with acute respiratory infections in Indonesian primary health clinics. Many such infections are viral and do not require antibiotics, …

This study tests whether ColdZyme mouth spray can lower the amount of virus people breathe out when they have a cold or flu. Researchers will measure virus particles in exhaled air before and after using the spray. The goal is to see if the spray might help reduce airborne transm…

This study is testing whether a dietary supplement called IDP (Immune Defense Protein) can reduce the length and severity of cold and flu symptoms in people aged 60 and older. About 300 participants will take either a low or high dose of IDP or a placebo daily during cold and flu…

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This study tests whether giving oral antibiotics instead of IV antibiotics is just as safe and effective for patients with common infections like pneumonia, urinary tract infections, and cellulitis. About 4,000 adults in Danish emergency rooms will be randomly assigned to start o…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study is testing a finger-prick blood test called FebriDx in 800 children aged 2-11 who have a fever and symptoms of a respiratory infection. The goal is to see if the test can quickly tell whether the infection is caused by bacteria or something else (like a virus). If accu…

This study tests a new technology called Pictura Bio that aims to detect respiratory viruses quickly and cheaply from nose or throat swabs. Researchers will collect samples from 1000 adults and children with suspected viral infections at a UK hospital. The data will be used to tr…

This study is testing new rapid tests (lateral flow and microfluidic devices) to detect respiratory infections in children and adults in Uganda, Ethiopia, and Senegal. Researchers want to see if these tests are accurate and easy to use in low-resource clinics. Participants with r…

This study is testing whether measuring a natural immune marker called IFN-I in nasal swabs can help detect respiratory viral infections in older adults. Current PCR tests only look for a few viruses and can miss others or show old infections. The goal is to improve diagnosis, es…

This study is testing a new diagnostic tool that helps doctors quickly tell if a respiratory infection is caused by bacteria or a virus. The goal is to see if using this test leads to better treatment decisions, fewer unnecessary antibiotics, and lower healthcare costs. About 100…

This study tests an oral drug called vapendavir in 180 adults with COPD who catch a rhinovirus (common cold). The goal is to see if it can reduce the severity and length of breathing symptoms compared to a placebo. Participants are randomly assigned to one of two doses or a place…

This study will test four medical devices (HMG, PHN, PHR, TUR) in 160 adults with sore throat from acute pharyngitis or viral tonsillitis. The goal is to see if they are safe and help reduce symptoms like pain when swallowing. Participants will use the device for up to 7 days and…

This study tests a new pill containing three ingredients (dipyrone, caffeine, and chlorpheniramine) to see if it works as well as a standard cold medicine for relieving stuffy nose and other cold and flu symptoms. About 620 adults with early cold or flu symptoms will take either …

This study is testing four medical devices (PIR, NS, NHE, NHG) in 150 adults with acute viral rhinitis, rhinosinusitis, or rhinopharyngitis (common cold). The goal is to see if they are safe and help reduce symptoms like sneezing, runny nose, and sore throat. Participants use the…

This study tests whether taking fish oil for 12 weeks can help the body adapt to cold by activating brown fat, which burns energy to produce heat. Thirty healthy adults aged 18-40 will take either fish oil or a placebo and then undergo a cold chamber challenge. Researchers will m…

This study tests two throat sprays (CDN and CW) for adults with a cough from a viral cold. About 58 people will use one of the sprays for 7 days and report how well it works and any side effects. The goal is to see if these sprays are safe and help ease cough symptoms.

This study tests whether a higher-dose version of the drug Ingavirin can help adults with the flu or other viral infections feel better faster. About 300 people will receive either the study drug or a placebo. The main goal is to see how quickly symptoms like fever, cough, and so…

This study tests whether a liquid medicine called Rengalin can safely reduce coughing in children aged 6 months to 3 years who have a viral cold or flu. About 264 children will take either Rengalin or a placebo three times a day for 7 days. The main goal is to see if more childre…

This study is testing a seawater spray mixed with essential oils to see how well it relieves nasal congestion from colds, sinus infections, or allergies. About 114 people aged 12 and older will use the spray for 7 days. The main goal is to see if nasal blockage improves after 3 d…

This study is testing a new seawater spray with essential oils to see if it safely relieves nasal congestion from colds, sinus infections, or allergies. About 101 people aged 12 and older will use the spray for 8 days. The main goal is to check if nasal stuffiness improves by at …

This study aims to collect blood, nose, and saliva samples from up to 20,000 people aged 3 and older who have or may have a respiratory virus infection like flu or COVID-19. The samples will be stored and used in future research to better understand these viruses and how the immu…

This study gathers fluid and tissue from the lungs and nose of healthy volunteers and people with a history of lung infections. Researchers will compare samples to find differences in immune function that might explain why some people are more prone to infections. Participants un…

This study aims to collect samples and medical information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to understand how viruses affect healthy individuals versus those with weakened immune systems. Pa…

This study will track which respiratory viruses—like flu, COVID-19, and RSV—are circulating in French primary care clinics each winter. Up to 25,000 patients with cold or flu symptoms will provide a saliva or nose swab sample. The goal is to monitor virus activity and help guide …

This study aims to identify the types of fungi causing pneumonia in immunocompromised ICU patients and test how resistant they are to antifungal drugs. Researchers will collect samples from 250 adults in intensive care who have pneumonia that does not respond to antibiotics. The …

This study tracks respiratory infections in thousands of patients across China to build a better early warning system. Researchers collect routine medical data and samples to identify which germs are circulating and how the body responds. The goal is to help hospitals and health …

This study tests whether implementing new Swiss national guidelines for acute respiratory infections can reduce unnecessary antibiotic prescribing in primary care. Researchers will work with 200 family doctors in quality circles and walk-in clinics, providing training and materia…

This study is observing 2,000 children under 2 years old in Ho Chi Minh City who have respiratory infections. Researchers will test for RSV, track how the virus spreads across seasons, and measure the illness's impact on families, including medical costs. No new treatments or vac…

This pilot study from Colorado State University will test 20 healthy adults (ages 18-40) to see if cold temperatures change how the body burns fat during exercise, and whether that change differs between females and males. Participants will exercise in both a normal room and a ve…

This study looks at whether having a respiratory infection in the past changes how your lungs react to ozone, a common air pollutant. One hundred healthy adults will breathe ozone while exercising and have their lung cells sampled. The goal is to understand why some people may be…

This study tests two ways to help general practitioners (GPs) use antimicrobial stewardship resources when treating respiratory tract infections. One group gets online training and self-audit tools; the other gets face-to-face support. Researchers will track how often GPs use the…

This study will follow 2,000 people of all ages who visit their doctor with symptoms of an acute respiratory infection, like cough, sore throat, or runny nose. Researchers will collect information on symptoms, treatments, and lab results to better understand how these infections …

This study looks at whether a quick lab test (Spotfire R/ST) can help doctors decide when antibiotics are truly needed for people with respiratory infections like colds or sore throats. About 800 urgent care patients will take part, and researchers will compare antibiotic use bef…

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This study will follow 1,000 adults who come to fever clinics with a respiratory infection. Researchers will collect data on symptoms, lab tests, and chest scans at the start, then check in over time to see who develops pneumonia or other complications. The goal is to better unde…

This study in Kyrgyzstan is testing whether using a rapid C-reactive protein (CRP) blood test and giving patients an information leaflet can help doctors prescribe fewer antibiotics for respiratory infections like coughs and sore throats. About 1050 adults will be randomly assign…