New RNA mpox vaccine shows promise in early trial
NCT ID NCT05988203
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tested an RNA-based vaccine called BNT166a against mpox (monkeypox) in 96 healthy volunteers. The goal was to check safety and see if the vaccine triggers an immune response. Researchers looked for side effects like pain, fever, and fatigue, and monitored serious reactions over several months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RNA-based mpox vaccine (BNT166a)
What this could lead to
If successful, this could lead to a new vaccine to protect against mpox (monkeypox).
What could go wrong
This is an early-phase trial with only 96 participants, so results may not apply to larger populations. The vaccine may cause side effects or fail to provide strong immunity.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Addenbrooke's Hospital - Cambridge University Hospitals NHS Foundation Trust
Cambridge, CB2 0QQ, United Kingdom
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Alliance for Multispecialty Research, LLC
Kansas City, Missouri, 64114, United States
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Alliance for Multispecialty Research, LLC
Knoxville, Tennessee, 37909, United States
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California Research Foundation
San Diego, California, 92123, United States
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Guy's and St Thomas' NHS Foundation Trust of St Thomas' Hospital
London, SE1 7EH, United Kingdom
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Medicine Evaluation Unit Ltd, The Langley Building, Wythenshawe Hospital
Manchester, M239QZ, United Kingdom
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Royal Surrey County Hospital Foundation Trust, NIHR Royal Surrey Clinical Research Facility
Guildford, GU2 7XP, United Kingdom
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University Hospital Southampton
Southampton, SO16 6YD, United Kingdom
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University of Washington Virology Research Clinic
Seattle, Washington, 98104, United States