Can a pill speed up monkeypox recovery? major trial underway

NCT ID NCT05597735

Ongoing Disease control Sponsor: ANRS, Emerging Infectious Diseases Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the antiviral drug tecovirimat can help people with monkeypox heal faster. About 480 adults and teens (14+) with active lesions will receive either tecovirimat or a placebo, alongside standard care. The main goal is to see how quickly skin and mouth sores clear up.

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Conditions

The condition(s) this trial relates to.

monkeypox

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MONKEYPOX MPOX

Contacts and locations

Locations

CHUV

Lausanne, Canton of Vaud, 1010, Switzerland
Emílio Ribas Institute of Infectious Diseases

São Paulo, Brazil
Evandro Chagas National Institute of Infectious Diseases-Oswaldo Cruz Foundation-FIOCRUZ

Rio de Janeiro, Brazil
Faculty of Medicine, Federal University of Minas Gerais

Belo Horizonte, Brazil
Federal Hospital for State Employees

Rio de Janeiro, Brazil
Fundación Huésped

Buenos Aires, C1204ABB, Argentina
Hôpitaux Universitaires de Genève

Geneva, Canton of Geneva, 1211, Switzerland
Nova Iguaçu General Hospital

Rio de Janeiro, Brazil
Pr Alexandra Calmy

Geneva, Canton of Geneva, 1211, Switzerland
STD/AIDS Reference and Training Center

São Paulo, Brazil
University Hospital Prof. Edgard Santos

Salvador, Brazil
Zürich checkpoint

Zurich, Canton of Zurich, Switzerland

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