Can a smallpox vaccine stop mpox in its tracks?

NCT ID NCT05745987

Ongoing Prevention Sponsor: McMaster University Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests whether giving the smallpox vaccine to people who have been exposed to mpox can prevent them from getting sick or reduce the severity of the disease. It involves about 3,000 household members of people with confirmed mpox, who receive either the vaccine or a control. The study also looks at how the vaccine affects symptoms, skin lesions, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bavarian Nordic smallpox vaccine (Imvamune)
What this could lead to: If effective, this could provide a proven way to prevent mpox in people exposed to the virus, reducing spread and easing symptoms.
What could go wrong: The trial is still in progress, and results may not confirm the vaccine's effectiveness. There are also risks of allergic reactions, and the vaccine may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

monkeypox prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MONKEYPOX

Contacts and locations

Locations

Aminu Kano Teaching Hospital

Kano, Nigeria
Catholic University of Bukavu

Kinshasa, Bukavu, Democratic Republic of the Congo
Federal Medical Center

Abuja, Nigeria
Irrua Specialist Teaching Hospital

Irrua, Nigeria
Lagos University Teaching Hospital

Lagos, Nigeria
Makerere University Lung Institute

Kampala, Kampala, Uganda
Niger Delta Teaching Hospital

Okolobiri, Nigeria
University of Abuja Teaching Hospital

Abuja, Nigeria
University of Ibadan

Ibadan, Nigeria
University of Port Harcourt Teaching Hospital

Port Harcourt, Nigeria

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