Monkeypox vaccine immune response under the microscope

NCT ID NCT05562323

Recruiting now Knowledge-focused Sponsor: Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study looks at how the monkeypox vaccine (MVA-BN) sparks immune responses in 100 adults at high risk of infection, including those with and without HIV. Researchers will measure antibodies and other immune markers in blood samples taken after vaccination. The goal is to understand if the vaccine works similarly in both groups, which could help protect vulnerable populations during outbreaks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MVA-BN vaccine
What this could lead to: If successful, this study could clarify how well the monkeypox vaccine works in different groups, including people with HIV, and guide future vaccination strategies.
What could go wrong: This is an observational study, not a treatment trial. It measures immune markers, not actual disease prevention, so real-world protection remains uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

monkeypox prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MONKEYPOX

Contacts and locations

Locations

BCN Checkpoint
RECRUITING

Barcelona, Barcelona, 08015, Spain
Germans Trias i Pujol Hospital
RECRUITING

Badalona, Barcelona, 08916, Spain
VALLE HEBRÓN HOSPITAL/Centro Salud Internacional y Enfermedades Transmisibles Drassanes
NOT_YET_RECRUITING

Barcelona, Barcelona, 08035, Spain

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