New flu vaccine shows promise for seniors in massive trial

NCT ID NCT06087640

Completed Prevention Sponsor: Seqirus Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This large study tested whether an enhanced flu vaccine (Fluad) works better than standard flu shots in adults aged 65 and older. Over 38,000 participants received either Fluad or a regular vaccine. The goal was to see if Fluad prevents confirmed flu cases more effectively. Results could help improve annual flu protection for older adults.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

MF59-adjuvanted influenza vaccine (Fluad or Fluad Quadrivalent)

What this could lead to

If successful, this could show that Fluad provides better flu protection for older adults than standard flu shots.

What could go wrong

The trial is complete, but results may not show a big advantage over standard vaccines, and individual responses vary.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLUENZA, HUMAN

Contacts and locations

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Locations

03601-University of the Sunshine Coast - Morayfield

Morayfield, Australia
03602-Emeritus Research - Melbourne

Camberwell, Australia
03603-University of the Sunshine Coast - Birtinya

Birtinya, Australia
03604-Doherty Clinical Trials Limited

Melbourne, Australia
03605-Emeritus Research - Sydney

Botany, Australia
03607-University of the Sunshine Coast - South Bank

South Brisbane, Australia
03608-Paratus Clinical Brisbane

Herston, Australia
03609-Paratus Clinical Western Sydney

Blacktown, Australia
03610-Paratus Clinical Central Coast

Kanwal, Australia
03611-Nucleus Network

Melbourne, Australia
03612-Wollongong Clinical Reserach

Wollongong, Australia
03613-Momentum Clinical Research Taringa

Taringa, Australia
03614-Northern Beaches Clinical Research

Brookvale, Australia
03615-Momentum Clinical Research Darlinghurst

Darlinghurst, Australia
05601-Jan Yperman Ziekenhuis

Ieper, Belgium
05602-Universitair Ziekenhuis Gent

Ghent, Belgium
05603-Medif BVBA

Gozée, Belgium
05605-AZ Sint-Jan Brugge-Oostende - Campus Sint-Jan

Bruges, Belgium
10004-Medical Center Prolet EOOD

Rousse, Bulgaria
10005-MHAT Dr. Tota Venkova

Gabrovo, Bulgaria
10006-DCC 22 - Sofia

Sofia, Bulgaria
10007-Medical Center Hera EOOD

Montana, Bulgaria
10012-Specialized Hospital For Active Treatment Of Pneumo-Phthisiatric Diseases Dr. Dimitar Gramatikov-Ruse EOOD

Rousse, Bulgaria
10014-Multi-Profile Hospital For Active Treatment Dr. Stamen Iliev AD

Montana, Bulgaria
10015-Medical Center Hera - Pulmonology Office

Sofia, Bulgaria
10016-Diagnostic Consultative Center - 1 - Sevlievo EOOD

Sevlievo, Bulgaria
10018-Medical Center - Zdrave-1

Kozloduy, Bulgaria
10019-MC Med Consult Pleven

Pleven, Bulgaria
10021-Medical Center Intermedica OOD

Sofia, Bulgaria
10022-Ambulatory Outpatient Medical Practice for First Patient Care Zaprin Pepelov

Plovdiv, Bulgaria
10023-DCC-1 Sliven

Sliven, Bulgaria
10024-Diagnostic Consultative Center PulMed EOOD

Plovdiv, Bulgaria
10026-Multiprofile Hospital for Active Treatment Sv. Panteleymon - Plovdiv

Plovdiv, Bulgaria
10027-AIPPMP Dr. Zhaneta Demireva

Stamboliyski, Bulgaria
10028-Medical Center Excelsior OOD

Sofia, Bulgaria
10029-Medical Centre Leo Clinic EOOD

Lovech, Bulgaria
10030-Diagnostic-Consultative Centre Ascendent EOOD

Sofia, Bulgaria
10031-Medical Centre Pratia Clinic EOOD

Plovdiv, Bulgaria
10032-Outpatient Clinic For Individual Practice For Primary Medical Care Dr. Valya Videnova-Avramova EOOD

Pazardzhik, Bulgaria
15801-China Medical University Hospital

Taichung, Taiwan
15802-National Cheng Kung University Hospital

Tainan, Taiwan
15803-Taipei Medical University - Shuang Ho Hospital

New Taipei City, Taiwan
15804-Taipei Medical University - Wanfang Hospital

Taipei, Taiwan
15805-Taipei Medical University Hospital

Taipei, Taiwan
20305-Centrum ockovani a cestovni mediciny

Hradec Králové, Czechia
20306-ADMED, s.r.o.

České Budějovice, Czechia
20307-CCR Brno s.r.o.

Brno, Czechia
20308-Zdravi - fit, s.r.o.

Protivín, Czechia
20309-CCR Ostrava, s.r.o.

Ostrava, Czechia
20310-MUDr. Jakub Strincl, s.r.o.

Liberec, Czechia
20311-Ordinace Hradebni s.r.o

České Budějovice, Czechia
20312-MEDISON s.r.o.

Přeštice, Czechia
24601-Tampere Vaccine Research Clinic

Tampere, Finland
24602-Oulu Vaccine Research Clinic

Oulu, Finland
24603-Helsinki South Vaccine Research Clinic

Helsinki, Finland
24604-Turku Vaccine Research Clinic

Turku, Finland
26801-LTD Hospital Service

Kutaisi, Georgia
26802-Acad. G. Chapidze Emergency Cardiology Center

Tbilisi, Georgia
26803-LTD "High Technology Hospital Medcenter"

Batumi, Georgia
26804-K. Eristavi National Center of Clinical Surgery

Tbilisi, Georgia
38001-PO A. Manzoni di Lecco, ASST Lecco

Lecco, Italy
38003-AOUC Policlinico di Bari

Bari, Italy
38004-Ospedale Fatebenefratelli e Oftalmico, ASST Fatebenefratelli Sacco

Milan, Italy
41001-Inha University Hospital

Incheon, South Korea
41002-Korea University Ansan Hospital

Ansan, South Korea
41003-Ajou University Hospital

Suwon, South Korea
41004-Hallym University Kangnam Sacred Heart Hospital

Seoul, South Korea
41005-Korea University Guro Hospital

Seoul, South Korea
44004-UAB InMedica

Kaunas, Lithuania
44008-JSC Saulės Šeimos Medicinos Centras

Kaunas, Lithuania
44009-Hospital of Lithuanian University of Health Sciences Kauno klinikos

Kaunas, Lithuania
44010-Inlita JSC Santara CTC

Vilnius, Lithuania
52802-Emotional Brain BV

Almere Stad, Netherlands
52804-Stichting European Clinical Research Alliance on Infectious Diseases

Utrecht, Netherlands
55401-Pacific Clinical Research Network - Auckland

Takapuna, New Zealand
55402-P3 Research Wellington

Wellington, New Zealand
55403-Optimal Clinical Trials - North

Rosedale, New Zealand
55404-Optimal Clinical Trials - Central

Grafton, New Zealand
55405-Pacific Clinical Research Network - West Auckland

New Lynn, New Zealand
60801-Davao Doctors Hospital

Davao City, Philippines
60802-West Visayas State University Medical Center

Iloilo City, Philippines
60803-Philippine General Hospital

Manila, Philippines
60804-St. Michael Family Hospital

Marilao, Philippines
60805-San Juan de Dios Hospital

Pasay, Philippines
60806-Quirino Memorial Medical Center

Quezon City, Philippines
60808-CARE Clinical Trial Group

Dasmariñas, Philippines
60811-Philippine General Hospital

Manila, Philippines
60812-Health Index Multispecialty and Lying-In Clinic

Bacoor, Philippines
60813-Norzel Medical and Diagnostic Clinic

Cebu, Philippines
60814-Manila Doctors Hospital

Manila, Philippines
60815-St. Paul's Hospital of Iloilo, Inc.

Iloilo City, Philippines
60816-St. Paul's Hospital of Iloilo, Inc.

Iloilo City, Philippines
60817-Silang Specialist Medical Center

Silang, Philippines
61605-RCMed Oddzial Sochaczew

Sochaczew, Poland
61614-KO-MED Centra Kliniczne Staszow

Staszów, Poland
61615-ETG Warszawa

Warsaw, Poland
61616-FutureMeds Targowek

Warsaw, Poland
61617-Przychodnia FutureMeds Wroclaw

Wroclaw, Poland
61618-FutureMeds Łódź

Lodz, Poland
61619-Krakowskie Centrum Medyczne Sp. z o.o

Krakow, Poland
61620-Velocity Nova Sp. z o.o.

Puławy, Poland
61621-Futuremed Warszawa Centrum

Warsaw, Poland
61622-KO-MED Centra Kliniczne Lublin II

Lublin, Poland
61623-KOMED Nova Zamość

Zamość, Poland
64204-Ames Research Center

Calarasi, Romania
64208-Spitalul Municipal Caracal

Caracal, Romania
64209-Clintrial Medical Center

Reșca, Romania
64210-Sana Monitoring

Bucharest, Romania
64211-Nova-Clin Medical Research Center

Timișoara, Romania
68802-Institute for Pulmonary Disease of Vojvodina

Kamenitz, Serbia
68803-Clinical Center of Serbia

Belgrade, Serbia
68804-General Hospital Valjevo

Valjevo, Serbia
68805-Clinical Hospital Center Zemun

Belgrade, Serbia
68806-CHC Bezanijska Kosa

Belgrade, Serbia
71001-Ubuntu Clinical Research Krugersdorp

Krugersdorp, South Africa
71003-Tsitsikamma Clinical Research Initiative

Plettenberg Bay, South Africa
71004-FCRN Clinical Trials Centre

Vereeniging, South Africa
71005-Be Part Research

Paarl, South Africa
71006-DJW Research

Krugersdorp, South Africa
71007-Josha Research Center

Bloemfontein, South Africa
71008-Madibeng Centre for Research

Brits, South Africa
71009-Newtown Clinical Research Centre

Newtown, South Africa
71010-Merclinico Middelburg

Middelburg, South Africa
71011-University of Cape Town Lung Institute

Cape Town, South Africa
71013-Into Research, Life Groenkloof Hospital

Pretoria, South Africa
71014-TREAD Research

Cape Town, South Africa
71015-Tiervlei Trial Centre

Cape Town, South Africa
71601-Charles River Medical Group, Mutala Trust and Infectious Disease Research Laboratory

Harare, Zimbabwe
72401-Hospital Ribera Povisa

Vigo, Spain
72402-EAP Vic - CAP El Remei

Barcelona, Spain
72403-Complexo Hospitalario Universitario De Santiago

Santiago de Compostela, Spain
72404-Hospital Universitario Son Espases

Palma de Mallorca, Spain
72405-Futuremeds Spain Madrid

Madrid, Spain
72406-Futuremeds Spain Sevilla

Seville, Spain
72407-Futurmeds Spain Cadiz

Cadiz, Spain
791210-Dokuz Eylul University Faculty of Medicine

Izmir, Turkey (Türkiye)
79204 - Kocaeli University Faculty of Medicine

Kocaeli, Turkey (Türkiye)
79205-Goztepe Suleyman Yalcin City Hospital

Istanbul, Turkey (Türkiye)
79207-Akdeniz University Faculty of Medicine

Antalya, Turkey (Türkiye)
79208-Izmir Dr. Suat Seren Pulmonary Hospital

Izmir, Turkey (Türkiye)
79209-Hacettepe University Faculty of Medicine

Ankara, Turkey (Türkiye)
79211-Karadeniz Technical University Faculty of Medicine

Trabzon, Turkey (Türkiye)
79212-Dicle Universitesi Tip Fakultesi

Diyarbakır, Turkey (Türkiye)
79213-Ege University Hospital

Izmir, Turkey (Türkiye)
84001-Revival Research Institute, LLC

Southfield, Michigan, 48075, United States
84002-ActivMed Practices and Research, LLC

Methuen, Massachusetts, 01844, United States
84003-DM Clinical Research - New Jersey

Jersey City, New Jersey, 07306, United States
84004-TMA Headlands LLC, dba Trial Management Associates

Wilmington, North Carolina, 28403, United States
84005-DM Clinical Research - Brookline

Brookline, Massachusetts, 02446, United States
84006-Nature Coast Clinical Research - Crystal River

Crystal River, Florida, 34429, United States
84007-Velocity Clinical Research - Omaha

Omaha, Nebraska, 68134, United States
84008-Global Health Research Center, Inc. - Tampa

Tampa, Florida, 33615, United States
84009-Velocity Clinical Research - Providence

East Greenwich, Rhode Island, 02818, United States
84010-M3 Wake Research/Charleston Clinical Trials, LLC

Charleston, South Carolina, 29414, United States
84011-Clinical Trials of Texas, LLC, dba Flourish Research

San Antonio, Texas, 78229, United States
84012-Evolution Clinical Trials

Doral, Florida, 33122, United States
84013-M3 Wake Research/Mount Vernon Clinical Research, LLC

Sandy Springs, Georgia, 30103, United States
84014-Asheville Clinical Research

Asheville, North Carolina, 28803, United States
84015-Trio Clinical Trials LLC

Houston, Texas, 77008, United States
84016-USA and International Research Inc.

Doral, Florida, 33126, United States
84017-Chase Medical Research, LLC

Waterbury, Connecticut, 06708, United States
84018-Quest Research Institute

Farmington Hills, Michigan, 48334, United States
84019-Green Leaf Clinical Trials

Jacksonville, Florida, 32258, United States
84020-M3 Wake Research/Raleigh Clinical Research, LLC

Raleigh, North Carolina, 27612, United States
84021-Velocity Clinical Research - Cleveland

Beachwood, Ohio, 44122, United States
84022-DM Clinical Research - River Forest

Melrose Park, Illinois, 60160, United States
84023-Velocity Clinical Research - Gulfport

Gulfport, Mississippi, 39503, United States
84024-St. Johns Center for Clinical Research

Saint Augustine, Florida, 32086, United States
84025-Velocity Clinical Research - Valparaiso

Valparaiso, Indiana, 46383, United States
84026-Health Awareness, Inc.

Jupiter, Florida, 33458, United States
84027-SIMEDHealth, LLC

Gainesville, Florida, 32607, United States
84028-Benchmark Research

Fort Worth, Texas, 76135, United States
84029-Imagine Research of Palm Beach County

Boynton Beach, Florida, 33435, United States
84030-Velocity Clinical Research - Grand Island

Grand Island, Nebraska, 68803, United States
84031-North Texas Family Medicine

Plano, Texas, 75093, United States
84032-Bioscope Clinical Research, LLC

Farmington Hills, Michigan, 48336, United States
84034-CTI Clinical Research Center

Cincinnati, Ohio, 45212, United States
84035-Monroe Biomedical Research

Monroe, North Carolina, 28112, United States
84036-Velocity Clinical Research - Suffolk

Suffolk, Virginia, 23435, United States
84037-Eximia Research - GA

Atlanta, Georgia, 30315, United States
84038-Kansas City Research Institute

Kansas City, Missouri, 64131, United States
84039-North Georgia Clinical Research

Woodstock, Georgia, 30189, United States
84040-Velocity Clinical Research - Norfolk

Norfolk, Nebraska, 68701, United States
84042-Velocity Clinical Research - Sioux City

Sioux City, Iowa, 51106, United States
84043-Velocity Clinical Research - Gaffney

Gaffney, South Carolina, 29340, United States
84044-Clarkston Medical Group

Clarkston, Michigan, 48346, United States
84045-Lynn Institute of the Ozarks

Little Rock, Arkansas, 72204, United States
84046-Accel Research Sites - Birmingham

Birmingham, Alabama, 35216, United States
84047-Velocity Clinical Research - Spartanburg

Spartanburg, South Carolina, 29303, United States
84048-Velocity Clinical Research - Binghamton

Binghamton, New York, 13905, United States
84049-Charlottesville Medical Research

Charlottesville, Virginia, 22911, United States
84050-3SYNC Research

Pittsburgh, Pennsylvania, 15241, United States
84051-Precision Clinical Research

Sunrise, Florida, 33351, United States
84052-Velocity Clinical Research - Lafayette

Lafayette, Louisiana, 70508, United States
84053-Velocity Clinical Research - Union

Union, South Carolina, 29379, United States
84054-Centricity Research Columbus

Columbus, Georgia, 31904, United States
84055-Velocity Clinical Research - Baton Rouge

Baton Rouge, Louisiana, 70809, United States
84056-Coastal Carolina Research Center, LLC

North Charleston, South Carolina, 29405, United States
84057-Sundance Clinical Research

St Louis, Missouri, 63141, United States
84058-Clinical Research Partners

Richmond, Virginia, 23226, United States
84059-DM Clinical Research - Sugar Land

Sugar Land, Texas, 77478, United States
84060-Great Lakes Clinical Trials LLC, dba Flourish Research

Chicago, Illinois, 60640, United States
84061-Velocity Clinical Research - New Smyrna Beach

Edgewater, Florida, 32132, United States
84062-Activian Clinical Research

Kingwood, Texas, 77339, United States
84063-Velocity Clinical Research - Cincinnati (Mt. Auburn)

Cincinnati, Ohio, 45219, United States
84064-Benchmark Research

Metairie, Louisiana, 70006, United States
84065-Fleming Island Center for Clinical Research

Fleming Island, Florida, 32003, United States
84066-Research Your Health

Plano, Texas, 75093, United States
84067-Innovative Research of West Florida, Inc.

Clearwater, Florida, 33756, United States
84068-WR-ClinSearch, LLC

Chattanooga, Tennessee, 37421, United States
84069-Velocity Clinical Research - Savannah

Savannah, Georgia, 31406, United States
84070-Baptist Health Center for Clinical Research

Little Rock, Arkansas, 72205, United States
84071-3SYNC Research

Lake Worth, Florida, 33460, United States
84072-WR-Global Medical Research, LLC

Dallas, Texas, 75224, United States
84074-DM Clinical Research - Southfield

Southfield, Michigan, 48076, United States
84075-Cullman Clinical Trials

Cullman, Alabama, 35055, United States
84076-DM Clinical Research - San Antonio

San Antonio, Texas, 78257, United States
84077-Velocity Clinical Research - Syracuse

East Syracuse, New York, 13057, United States
84078-Tekton Research

Yukon, Oklahoma, 73099, United States
84079-Progressive Medicine of the Triad, LLC

Winston-Salem, North Carolina, 27103, United States
84080-ACRC Trials

Plano, Texas, 75024, United States
84081-Suncoast Research Associates, LLC

Pembroke Pines, Florida, 33024, United States
84082-Global Health Research Center, Inc.

Miami Lakes, Florida, 33016, United States
84083-Accel Research Sites Network - St. Petersburg-Largo

Largo, Florida, 33777, United States
84084-Clinical Research Associates, Inc.

Nashville, Tennessee, 37203, United States
84085-Clinical Research Consulting, LLC

Milford, Connecticut, 06460, United States
84086-Agile Clinical Research Trials, LLC

Atlanta, Georgia, 30328-6124, United States
84087-DM Clinical Research - Tomball

Tomball, Texas, 77375, United States
84088-Velocity Clinical Research - Covington

Covington, Louisiana, 70433, United States
84089-Velocity Clinical Research - Durham

Durham, North Carolina, 27701, United States
84090-Alliance for Multispecialty Research, LLC

Knoxville, Tennessee, 37909, United States
84101-West Coast Research LLC

Dublin, California, 94568, United States
84102-Eximia Research - NC

Raleigh, North Carolina, 27607, United States
84103-Alliance for Multispecialty Research, LLC

Las Vegas, Nevada, 89119, United States
84104-Zillan Clinical Research

Inglewood, California, 90303, United States
84105-Eximia Research - CA

La Mesa, California, 91942, United States
84106-Las Vegas Clinical Trials

North Las Vegas, Nevada, 89030, United States
84107-Long Beach Research Institute

Long Beach, California, 90805, United States
84108-Boeson Research MSO

Missoula, Montana, 59804, United States
84109-Long Beach Clinical Trials

Long Beach, California, 90806, United States
84110-Tekton Research

Longmont, Colorado, 80501, United States
84111-Vector Clinical Trials

Las Vegas, Nevada, 89128, United States
84112-DM Clinical Research - Phoenix

Phoenix, Arizona, 85012, United States
84113-DM Clinical Research - Seattle

Seattle, Washington, 98122, United States
84114-Scottsdale Clinical Trials

Scottsdale, Arizona, 85260, United States
84115-Central Valley Research

Modesto, California, 95350, United States
84117-M3 Wake Research/CRCN

Las Vegas, Nevada, 89106, United States
84118-Velocity Clinical Research - Boise

Meridian, Idaho, 83642, United States
84119-Apex Clinical Research

San Diego, California, 92120, United States
84120-Paradigm Research

Redding, California, 96001, United States
84121-Velocity Clinical Research - Medford

Medford, Oregon, 97504, United States
84122-Albuquerque Clinical Trials

Albuquerque, New Mexico, 87102, United States
84123-Paradigm Research

Wheat Ridge, Colorado, 80033, United States
84124-Leading Edge Research

Encino, California, 91316, United States
84125-Lynn Institute of Denver

Aurora, Colorado, 80012, United States