Can a new shot help control hepatitis d in people with hepatitis b?

NCT ID NCT04535544

Completed Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether adding an experimental drug called JNJ-73763989 to standard oral antivirals can better suppress hepatitis D virus in people who are also infected with hepatitis B. About 52 adults with stable chronic co-infection will receive either the combination or a placebo plus antivirals. The goal is to see if the added drug leads to a significant drop in hepatitis D levels and improves liver enzyme readings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental drug called JNJ-73763989 (JNJ-3989) given as a shot, plus standard oral antivirals (entecavir, tenofovir disoproxil, or tenofovir alafenamide)
What this could lead to: If successful, this combination could offer a more effective way to suppress hepatitis D virus and improve liver health in people with chronic co-infection.
What could go wrong: This is a mid-stage trial with only 52 participants, so results may not apply broadly. The experimental drug is injected and may cause side effects, and it is unclear if it will outperform standard therapy alone.

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Conditions

The condition(s) this trial relates to.

hepatitis B virus infection hepatitis D virus infection Hepatitis D, Chronic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATITIS D, CHRONIC

Contacts and locations

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Locations

Azienda Ospedaliero Universitaria Pisana

Pisa, 56124, Italy
Beijing Ditan Hospital Capical Medical University

Beijing, 100015, China
CHU Hopital Saint Antoine

Paris, 75012, France
CHU de Nantes hotel Dieu

Nantes, 44093, France
Centro Oncológico De Roraima

Boa Vista, 69304015, Brazil
Cepem - Centro de Pesquisa Em Medicina Tropical

Porto Velho, 76812-329, Brazil
China Medical University Hospital

Tiachung, Taiwan
Chu Rennes Hopital Pontchaillou

Rennes, 35033, France
Danderyds Sjukhus

Danderyd, 18288, Sweden
Ege University Medical of Faculty, Department of Gastroenterology

Izmir, 35100, Turkey (Türkiye)
Fundacao De Medicina Tropical Doutor Heitor Vieira Dourado

Manaus, 69040-000, Brazil
Guangzhou Eighth People's Hospital, Guangzhou Medical University

Guangzhou, 510000, China
Harvard Medical School Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital

Hiroshima, 730-8619, Japan
Hopital Beaujon

Clichy, 92110, France
Hopital de La Croix Rousse

Lyon, 69004, France
Hosp Clinic de Barcelona

Barcelona, 8028, Spain
Hosp Univ Vall D Hebron

Barcelona, 8035, Spain
Hosp. Univ. 12 de Octubre

Madrid, 28041, Spain
Hosp. Univ. Marques de Valdecilla

Santander, 39008, Spain
Huashan Hospital Fudan University

Shanghai, 200040, China
Ikeda City Hospital

Ikeda, 563-8510, Japan
Irccs Ospedale Maggiore Di Milano

Milan, 20122, Italy
Istanbul University Cerrahpasa Medical Faculty

Istanbul, 34098, Turkey (Türkiye)
Kaohsiung Medical University Chung Ho Memorial Hospital

Kaohsiung City, 80756, Taiwan
Karadeniz Teknik University Medical Faculty

Trabzon, 61080, Turkey (Türkiye)
Karolinska Universitetssjukhuset Huddinge

Stockholm, 14186, Sweden
Kings College Hospital

London, SE5 9RF, United Kingdom
Kocaeli University Medical Faculty

Kocaeli, 41001, Turkey (Türkiye)
Krasnoyarsk Regional Center For AIDS And Infectious Diseases Treatment And Prophylaxis

Krasnoyarsk, 660049, Russia
Kumamoto Shinto General Hospital

Kumamoto, 862 8655, Japan
Kumamoto University Hospital

Kumamoto, 860-8556, Japan
Medical Company Hepatolog Ltd

Samara, 443045, Russia
Medizinische Hochschule Hannover

Hanover, 30625, Germany
Nagasaki University Hospital

Nagasaki, 852-8501, Japan
Nakagami Hospital

Okinawa, 904-2195, Japan
Nanfang Hospital

Guangzhou, 510515, China
National Hospital Organization Nagasaki Medical Center

Nagasaki, 856-8562, Japan
National Hospital Organization Shikoku Cancer Center

Iizuka-shi, 820-8505, Japan
National Taiwan University Hospital

Taipei, 10002, Taiwan
New Zealand Clinical Research

Auckland, 1010, New Zealand
Osaka University Hospital

Suita-shi, 565-0871, Japan
Ospedale Molinette, AO Città della Salute e della Scienza di

Torino, 10126, Italy
Peking University People s Hospital

Beijing, 100044, China
Royal Prince Alfred Hospital

Camperdown, 2050, Australia
Skanes universitetssjukhus

Malmö, 20502, Sweden
St. Petersburg City Center for AIDS and Infectious Diseases Treatment and Prophylaxis

Saint Petersburg, 190103, Russia
Stanford University School of Medicine

Redwood City, California, 94063, United States
Suita Municipal Hospital

Suita, 564-8567, Japan
The First Affiliated Hospital Zhejiang University College of Medicine

Hangzhou, 310003, China
The First Bethune Hospital of Jilin University

Changchun, 130021, China
The Second Affiliated Hospital of Chongqing Medical University

Chongqing, 400010, China
Tokyo Medical and Dental University Hospital

Bunkyō City, 113 8519, Japan
Tokyo Metropolitan Bokutoh Hospital

Sumida Ku, 130 8575, Japan
Universita degli Studi di Roma 'La Sapienza' - Umberto I Policlinico di Roma

Rome, 00161, Italy
Universitatsklinikum Essen

Essen, 45147, Germany
University of the Ryukyus Hospital

Nakagami Gun, 903-0215, Japan
Universitätsklinikum Johann Wolfgang Goethe- Universität Frankfurt Medizinische Klinik 1

Frankfurt, 60590, Germany
West China Hospital Sichuan University

Chengdu, 610041, China
Western Health

Footscray, 3011, Australia
Westmead Hospital

Westmead, 2145, Australia

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