Lentivirus infection

This early-stage trial tests two experimental mRNA vaccines designed to train the immune system to make special antibodies that could block HIV. The study involves 40 healthy adults without HIV who will receive the vaccines and be monitored for safety and immune responses. It is …

This study tests the Shingrix vaccine in people with HIV and healthy volunteers to see how well it boosts immunity against shingles. Participants receive two shots two months apart and are followed for a year. The goal is to understand if the vaccine works safely in those with di…

This early-stage trial is testing a new HIV vaccine booster called VRIPRO, given with an immune-boosting adjuvant, in 40 healthy adults aged 18-60 who previously received an HIV vaccine in the HVTN 706 study. Participants will get three shots over 24 weeks. The main goals are to …

This study tests three new HIV vaccines in healthy adults aged 18-49 to see if they are safe and trigger an immune response. Two vaccines are given as nasal sprays, followed by a booster shot. The trial also monitors household and intimate contacts to check if the vaccine viruses…

This early-stage trial tests an experimental HIV vaccine called ICVAX in 22 adults with HIV who are stable on antiretroviral therapy (ART). The goal is to see if the vaccine is safe and can strengthen the body's immune response against HIV. Participants receive four injections ov…

This study is testing a new tuberculosis vaccine called MTBVAC in 276 adolescents and adults in South Africa, some of whom have HIV. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants will receive either MTBVAC or the standard BCG vaccin…

This Phase 1 trial is testing a new HIV vaccine called GRAdHIVNE1, made using a harmless gorilla virus to deliver HIV protein pieces. The study will enroll 120 healthy adults in southern Africa, some living with HIV and some without, to check safety and measure immune responses. …

This study looks at whether giving two doses of the HPV vaccine instead of three can protect women living with HIV just as well. Researchers will compare immune responses in 275 Canadian women aged 18-45 who have not been vaccinated before. If two doses work, it could make HPV va…

This study tests a new oral cholera vaccine (Biovac OCV-S) to see if it works as well as a currently approved vaccine (Euvichol-Plus). About 2,824 healthy people aged 1 to 45, including some adults living with HIV, will receive two doses. Researchers will check immune responses a…

This early-stage trial tests whether a new HIV vaccine combination is safe and can trigger an immune response. About 78 healthy adults will receive either the vaccine or a placebo. The study uses two different dosing schedules to see which works better.

This Phase 1 trial tests a two-part HIV vaccine regimen in 42 healthy adults without HIV. The first shot primes the immune system, and later booster shots aim to mature antibody-producing cells. The main goal is to see if the regimen is safe and whether it triggers a specific imm…

This study tests a program called Mentor Moms+ for pregnant women in South Africa who drink alcohol. Trained mentor mothers—women who have successfully reduced alcohol use while on HIV medication—provide one-on-one counseling sessions. The goal is to see if this approach helps wo…

This study tests whether a combination of three drugs (cyclophosphamide, bortezomib, and maraviroc) can safely prevent graft-versus-host disease after a half-matched bone marrow transplant in people living with HIV who also have a blood cancer. The trial involves 265 participants…

This trial tests whether a two-drug combination (darunavir/cobicistat plus lamivudine) works as well as a standard three-drug combination (darunavir/cobicistat plus tenofovir alafenamide/emtricitabine) in people with HIV whose virus is already suppressed. The study involves 78 ad…

This study tests a program to help women living with HIV in Ghana get screened for cervical cancer more easily. The program includes self-sampling kits, patient navigators, and training for healthcare providers. Researchers want to see if these tools increase screening rates and …

This study tests a new long-acting injectable drug called VH4524184 in healthy adults to see if it is safe and how the body handles it. The goal is to find a dose that could one day help control HIV with fewer shots. About 268 volunteers will receive either the drug or a placebo …

This study tests whether community health workers (CHWs) can help Black people with poorly controlled HIV achieve long-term viral suppression. CHWs provide support through weekly phone calls, home visits, and clinic accompaniment for three months. The study enrolls 10 Black adult…

This study tests whether adding the drug lenacapavir to standard HIV treatment can reduce the hidden HIV reservoirs that remain in the body. About 50 adults with well-controlled HIV will either continue their usual therapy or receive lenacapavir injections plus pills. Researchers…

This study tests a program that sends personalized text messages and provides nicotine patches to help people with HIV in Cambodia stop smoking. Researchers will enroll 800 smokers and check if they quit after 6 months using self-reports and breath tests. The goal is to find a pr…

This study tests whether a combination of a special diet, omega-3 and L-carnitine supplements, and resistance exercise can improve muscle quality and reduce fat in veterans with HIV and obesity. The trial will enroll 70 participants and measure changes in muscle density, metaboli…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This early-stage study tests whether a single dose of an experimental drug called IAP086 is safe in 30 adults with HIV whose virus is already well-controlled by standard antiretroviral therapy. Participants receive one intravenous infusion and are monitored closely for 28 days. T…

This study tests a 5-session virtual program called MATTER for 256 people living with HIV and substance use disorders in Boston and Miami. The program uses text messages and coaching to help people manage shame and stigma, set health goals, and stay connected to HIV care. The goa…

This large platform trial is testing new antifungal drug combinations for cryptococcal meningitis, a severe brain infection that is fatal without treatment and common in people with HIV. The study will enroll 2,000 participants across multiple sites to compare a newer oral drug, …

This study follows 200 people with HIV who need a kidney transplant. Half will receive a kidney from a donor with HIV, half from a donor without HIV. Researchers track how many patients experience organ rejection or death over time to see if donor HIV status affects outcomes.

This early-stage study tests a new antibody called BNT351 in 67 adults, both with and without HIV. The goal is to check safety, how long the antibody stays in the blood, and whether it can lower HIV levels in people with the virus. It is a first step toward possibly controlling H…

This study investigates whether a mobile app called reSET can help men who have sex with men, are living with HIV, and have a stimulant use disorder reduce their drug use and keep their HIV under control. Participants use the app for 12 weeks, completing modules on topics like ma…

This study tests whether a simple text-message system can help caregivers in Kenya spot and prevent malnutrition in children exposed to HIV. About 776 caregiver-child pairs will be split into two groups: one gets weekly SMS reminders to measure the child's arm and receive feeding…

This study tests a behavioral program for sexually active young people aged 16-24 who use stimulants like meth, cocaine, or MDMA. The goal is to help them reduce stimulant use and lower the risk of passing or getting HIV. Participants will receive counseling and support through v…

This study tests whether giving very early and intensive antiretroviral therapy, plus an antibody, can help infants with HIV achieve remission—meaning the virus stays undetectable even after stopping treatment. Researchers will enroll about 1,120 infants and follow them for safet…

This study tests whether adding the HIV drug rilpivirine to standard treatment can help people with HIV whose immune systems haven't fully recovered. About 21 adults with low CD4 counts despite years of successful viral suppression will receive rilpivirine for 48 weeks. The goal …

This study tests a short counseling program (about 4 sessions) designed to help pregnant and postpartum women in Cape Town, South Africa, keep taking their daily HIV-prevention pill (PrEP). Many women stop PrEP due to depression or trauma from violence. The program uses cognitive…

This study tests a mobile app called DynamiCare, combined with a patient navigator, to help people recently released from jail or prison reduce their use of stimulants like methamphetamine or cocaine. The app uses at-home saliva tests and financial rewards to encourage healthy be…

This early-stage trial is testing whether lab-made antibodies that target HIV are safe and how long they stay in the body. About 83 healthy adults without HIV will receive the antibodies by vein or under the skin, alone or in combination. The goal is to find the right dose and ch…

This study offers continued access to HIV medications for children and adolescents who completed a previous Gilead HIV treatment study. About 350 participants will receive their study drug or switch to a standard HIV medication, and researchers will monitor for side effects. The …

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This study tests whether a special T-cell vaccine, combined with an immune-boosting drug (vesatolimod) and two powerful antibodies, can help people with HIV control the virus without needing daily antiretroviral therapy. The trial involves 36 adults who started HIV treatment soon…

This study looks at how well a long-acting injectable HIV treatment works in people with HIV-1 subtype A6, a common type in Eastern Europe. Researchers will compare medical records from 250 adults in Poland, Germany, and the Czech Republic who have already received the shots. The…

This study tests whether a once-weekly combination of two experimental drugs (islatravir and ulonivirine) works as well as the standard daily three-drug pill Biktarvy for people newly diagnosed with HIV-1. About 570 adults who have never taken HIV medication will be randomly assi…

This study tests two smoking cessation methods—varenicline pills and nicotine patches with gum—in 660 people with HIV in South Africa. Participants will receive one of these treatments for 12 weeks, along with counseling. The goal is to see which approach works best to help them …

This study tests a daily combination pill (TLD) as first-line HIV treatment for 100 people who became infected with HIV despite receiving long-acting cabotegravir PrEP in the past year. Researchers will check if the pill can suppress the virus to undetectable levels after 6 month…

This study tests a program called Friendship Bench + Safety Planning for teens aged 13-19 living with HIV who have had suicidal thoughts. The goal is to see if the program is practical, acceptable, and helps reduce suicidal thoughts and improve engagement in HIV care. Sixty parti…

This phase 1 study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), in adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs can shrink tumors. Up to 58 people with Kapo…

This study is testing whether a smartphone app designed for people with HIV can help them quit smoking when combined with a lung cancer screening CT scan. About 100 participants will use the app and get a low-dose CT scan. The goal is to see if this approach is practical and help…

This study tests whether dasatinib, a drug used for leukemia, can reduce the hidden HIV reservoir in people whose virus is already suppressed by antiretroviral therapy (ART). Fourteen adults on ART for at least 4 years will be randomly assigned to take dasatinib or a placebo dail…

This study tests two drugs, PDS01ADC and M7824, that work with the immune system to fight Kaposi sarcoma (KS), a cancer often linked to HIV or organ transplants. The trial enrolls 80 adults with advanced KS that has not responded well to prior therapy. Participants receive PDS01A…

This study tests a program called Full-SPARCS, where trained peers lead group sessions to help people with HIV stay in care after they leave prison in South Africa. The program includes one-on-one check-ins and group meetings in community centers. Researchers will compare viral s…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This study tests whether offering a choice of e-cigarettes, nicotine pouches, or nicotine patches helps people with HIV stop smoking tobacco. About 972 participants in Switzerland will receive their preferred product free for 6 months, plus standard care. The main goal is to see …

This study in Botswana tests whether giving three powerful antibodies by infusion can help children who started HIV treatment early keep the virus suppressed without taking daily antiretroviral pills. About 41 children aged 2 to 12 will receive the antibodies while stopping their…

This trial tests a program called WeCare, which combines problem-solving therapy with support for taking HIV medication. It is designed for men who have sex with men (MSM) in South Africa. The study will enroll 60 participants to see if the program reduces depression and anxiety,…

This study tests four approaches to help adults with drug-resistant tuberculosis and HIV stick to their treatments. Participants receive either standard care, counseling, phone reminders via a special pill bottle, or both counseling and reminders. The goal is to see which method …

This study tests whether semaglutide, a drug used for diabetes, can help adults with HIV reduce their alcohol intake and smoking, and lower their risk of heart disease. About 200 participants will take semaglutide or a placebo for 3 months and provide blood, stool, and saliva sam…

This study tests if tirzepatide, a weekly injection, can help overweight or obese people with well-controlled HIV lose weight and reduce chronic inflammation. Twelve adults will receive increasing doses over 12 weeks, with a 4-week safety follow-up. Researchers will measure chang…

This study tests a long-acting injectable HIV medication (CAB LA + RPV LA) in people whose virus is still detectable despite taking daily oral pills. About 332 participants will either get the shots or continue standard oral therapy. The goal is to see if the injections can bette…

This study looks at whether the HIV drug cabotegravir is safe for newborns who were exposed to HIV during birth. About 44 healthy babies will receive the drug either by mouth or injection. The goal is to find the right dose and check for side effects, helping to protect these inf…

This phase 2 trial tests whether adding tesamorelin (a growth-hormone-releasing hormone analogue) to a home-based exercise program can improve physical function in 100 adults aged 50-80 with HIV. Participants are randomly assigned to receive tesamorelin or a placebo injection dai…

This study tests a program called ARC that helps HIV clinics improve their work environment and reduce discrimination. Researchers will compare viral suppression and care retention in clinics using ARC versus standard care. The goal is to see if better clinic culture leads to bet…

This study is testing a long-acting injectable medication for children aged 2 to 12 who have HIV and whose virus is already under control. The goal is to see if switching from daily pills to a shot given every few weeks is safe, tolerable, and effective. About 90 children will pa…

This study tests whether a mobile app with a virtual group support feature can help young Black women (ages 18-30) who misuse alcohol reduce their drinking and risky sexual behavior, and increase their use of PrEP (a daily pill that prevents HIV). About 500 HIV-negative women in …

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for HIV or already living with it, and who also have substance use issues. The program provides prevention, treatment, and support to help them start HIV prevention medication (PrEP) or lo…

This study tests a program called Mlambe for married couples in Malawi where one partner drinks heavily and both are affected by HIV. The program offers savings accounts, money management classes, and relationship skills training to help couples reduce alcohol use. Researchers wi…

This study tests a program called Kisoboka for men living with HIV who drink heavily in fishing communities. The goal is to help them drink less, take their HIV medication as prescribed, and achieve undetectable viral loads. About 716 men will be randomly assigned to different co…

This study is testing an experimental injection called LP-98 in 30 adults with HIV who have never taken HIV medication. The goal is to see if the drug can safely lower the amount of virus in the blood and improve immune cell counts. Participants will receive the injection and be …

This study tests whether personalized text messages can help HIV-positive women in Africa who sell sex take their antiretroviral therapy (ART) regularly. 350 women will either get standard care or standard care plus text reminders and tips for six months. The goal is to see if mo…

This study tests a lab-made human protein called CYT107 in 55 people with HIV and Kaposi sarcoma. The protein aims to boost T cells, which may help shrink cancer tumors. Participants receive weekly injections for up to 4 weeks, with follow-up for 3 years.

This study is testing a new experimental drug called VH4524184 for people with HIV-1 who have never taken HIV medication before. About 150 adults will receive either a low or high dose of VH4524184 along with two standard HIV drugs (emtricitabine and tenofovir alafenamide), or a …

This early-stage trial tests whether venetoclax, a drug used for certain blood cancers, can help eliminate the hidden HIV reservoir. The study enrolls 38 adults newly starting HIV therapy. Participants receive venetoclax in three short cycles while researchers monitor safety and …

This study tests a program called Tunawiri (meaning 'thrive') that adds mental health screening, counseling, and support to regular HIV care for pregnant and postpartum women in Kenya. The goal is to improve depression, anxiety, and HIV treatment success. Nine hundred women will …

This study tests a drug called abemaciclib, already used for breast cancer, in people with Kaposi sarcoma (KS), both with and without HIV. The goal is to find a safe dose and see if it can shrink KS tumors. About 111 adults will take the drug daily in 28-day cycles until their ca…

This study compares two antibiotics for treating early syphilis: a single penicillin shot (standard care) versus a 14-day course of cefixime pills. Researchers want to see if the pill works just as well. The study includes 400 adults with early syphilis, including those with well…

This study provides free testing for chlamydia, gonorrhea, syphilis, and HIV to Black youth aged 15-26 in New Orleans. Those who test positive can get treatment at no cost and are encouraged to bring their partners. The goal is to reduce STI rates and health disparities in this c…

This study tests whether resmetirom, a drug already approved for another liver condition, can safely reduce liver fat in people with HIV who also have fatty liver disease (MASLD). About 120 adults with well-controlled HIV will take either resmetirom or a placebo daily for 24 week…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This study tests whether adding one dose of a stronger antifungal drug (liposomal amphotericin) to the standard treatment (fluconazole) can prevent cryptococcal meningitis in HIV-positive adults who test positive for the fungus but have no symptoms. About 356 participants in Ugan…

This study tests a 5-session program for Black women living with HIV who have experienced intimate partner violence in the past two years. The program teaches skills to find inner strength, build a safety net, improve communication, and overcome barriers to HIV care. Researchers …

This study tests whether semaglutide (Ozempic) helps people with HIV and obesity lose more weight than diet and exercise alone. About 80 participants will receive either semaglutide injections or standard lifestyle advice for 28 weeks. Researchers will also check how the drug aff…

This study tests an HIV medicine called doravirine in children aged 4 weeks to under 12 years who weigh less than 45 kg. The goal is to see how the drug works in their bodies and if it is safe. About 84 children who are either new to treatment or already have the virus under cont…

This study tests a program called Enhanced Friendship Bench that combines problem-solving therapy with HIV support for pregnant women in Malawi who have HIV and depression. About 400 women will take part to see if the program reduces depression symptoms and helps them stay in HIV…

This study tests a long-acting HIV medicine called lenacapavir (Sunlenca®) in 12 adolescents and children with HIV who have tried other treatments. Participants take lenacapavir as pills and injections along with their other HIV drugs. The goal is to see if the combination is saf…

This study tests whether giving two powerful HIV-fighting antibodies along with standard HIV medication (ART) to people diagnosed very early with HIV can help them control the virus without daily pills later. 48 adults with acute HIV infection will receive either the antibodies o…

This study tests a program to reduce stigma for women in Botswana who have both HIV and a serious mental illness. The program helps women challenge negative stereotypes and build coping skills after leaving a psychiatric hospital. Researchers will compare viral suppression rates …

This study tests whether metformin, a common diabetes drug, can reduce harmful inflammation and improve immune function in 100 adults aged 18-64 who have a history of injection drug use, some of whom also have HIV. Participants take metformin or a placebo for 16 weeks and receive…

This study tests a harm reduction strategy for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, the program helps participants cut down on smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to improve o…

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study tests a new way to help people with HIV in rural Uganda. Traditional healers will be trained to offer HIV testing, counseling, and support to take medication regularly. The goal is to see if this extra help, alongside regular clinic care, can help more people achieve a…

This study tests whether high-dose zinc supplements can improve immune function in people with HIV who still have low CD4 counts despite successful antiretroviral therapy. 120 participants will receive either zinc or a placebo for 16 weeks. Researchers will measure changes in CD4…

This study tests a CAR-T cell therapy (axicabtagene ciloleucel) in 20 HIV-positive adults whose aggressive B-cell lymphoma has come back or stopped responding to standard treatment. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells. The …

This study looks at whether giving young women (ages 15-24) in Kenya a long-acting injectable HIV medication along with a birth control implant is safe and works well. Researchers will check hormone levels and HIV viral suppression in 700 participants. The goal is to simplify car…

This study is testing a combination of counseling, peer mentoring, text messages, and nicotine replacement therapy to help people with HIV quit smoking. Researchers will enroll 500 smokers living with HIV in New York City to find the most effective and affordable approach. The go…

This early-phase trial tests whether specially engineered immune cells (CAR-T cells) can control HIV in people who stop their regular antiretroviral drugs. 18 participants will receive a single infusion of their own modified cells, with some also getting a mild chemotherapy drug …

This study tests whether having a trusted friend or family member (a Support Confidant) can help people with HIV keep their medical appointments and lower their virus levels. Researchers will enroll 900 people aged 18-49 in Chicago and Alabama who have missed visits or had unsupp…

This study tests two programs to help young people aged 15-24 in Nigeria. One program focuses on finding undiagnosed HIV cases using mobile health tools and peer support. The other helps those already diagnosed stick to their HIV medication to achieve viral suppression. The goal …

This phase 2 trial is testing whether a combination of three lab-made antibodies is safe and tolerable in 200 healthy adults without HIV. Participants receive one or more IV infusions of the antibodies and are followed for 18 months. The goal is to see if this approach could even…

This study in South Africa tests whether peer support and long-acting injectable HIV medication help teens (ages 12-19) stay virally suppressed and keep up with care. 720 teens living with HIV will take part. The goal is to see if these approaches improve health and retention ove…

This study aims to help people with HIV stay in care, especially during the first six months of treatment when the risk of dropping out is highest. Researchers will create and test a toolkit that includes risk assessments, a treatment roadmap, and a WhatsApp support coach. The st…

This study tests a couple-based problem-solving therapy for pregnant women living with HIV who also have depression. The goal is to improve their mental health and help them stick to their HIV medication, which prevents passing the virus to their baby. The trial will enroll 180 c…

This study tests a program that combines peer support and text message reminders to help young LGBTQ+ people with HIV in Nigeria stay on their medication and lower their virus levels. One hundred participants aged 15-29 will receive the program for 24 weeks. The goal is to see if…

This study tests a mutual-help group called the TLC Program for transgender adults who struggle with substance use or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy to improve mental health and reduce HIV risk…

This pilot study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with HIV reduce their alcohol use. Thirty participants will receive the drug along with support from a pharmacist and psychiatrist. The goal is to see if this approach is feasibl…

This study tests a new way to help doctors in Mozambique and Zambia decide if a sick child has tuberculosis (TB). The approach uses simple checklists and decision guides, supported by a computer system, to improve diagnosis and treatment, especially for children with HIV or sever…

This Phase 2 trial tests whether baricitinib, an FDA-approved arthritis drug, can reduce the amount of HIV hiding in the central nervous system. 95 people with HIV on stable antiretroviral therapy will receive either baricitinib or a placebo for 10 weeks. Researchers will measure…

This study looks at a Philadelphia program called Arms Around You, which provides housing to people with HIV who are experiencing housing instability. Researchers will compare 200 people who get into the program right away versus those on a waitlist, tracking their health, housin…

This study tests three approaches to help older adults with HIV become more physically active: one-on-one coaching, cognitive behavioral therapy to overcome barriers like low motivation or pain, and a Fitbit-based social support program. About 196 participants will wear a Fitbit …

This pilot study tests whether adding the HIV drug efavirenz to a person's current antiretroviral therapy (ART) can kill cells that harbor hidden HIV. About 26 adults with HIV who have low but detectable virus levels despite good adherence will take efavirenz for 8 weeks. The goa…

This study tests different approaches to help people with HIV whose current medication (tenofovir, lamivudine, and dolutegravir, or TLD) is no longer working. It involves 648 adults and teens in Uganda and South Africa. The goal is to find the best strategy to get the virus under…

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This study tests whether giving monthly cash payments to pregnant women with HIV in Botswana helps them better manage their health. Researchers want to see if the money improves their ability to stick to HIV medication and stay in care after giving birth. About 100 women will tak…

This study tests a program called reSTART for men living with HIV who also use stimulants. It combines a smartphone app, a urine test to check medication levels, and motivational messages to help them remember to take their HIV drugs. The goal is to see if this approach can lower…

This early-stage trial tests whether a patient's own immune cells, modified to target HIV (called CAR-T cells), can help control the virus without daily medication. Only 3 people with well-controlled HIV will receive the treatment. The main goal is to check safety, but researcher…

This study tests whether a team-based program (called ARTAS) helps people with HIV get connected to care after leaving the hospital and reduces the chance of coming back. The team includes infectious disease doctors and social workers who provide support during the hospital stay …

This study tests a mobile app called WiseApp along with a smart pill dispenser to help Spanish-speaking people with HIV take their medication regularly. About 248 participants from New York City and the Dominican Republic will use the app for 12 months. The goal is to see if the …

This early-phase study tests whether specially engineered immune cells (CMV-HIV CAR T cells) can help control HIV in people already on antiretroviral therapy (ART). The goal is to see if these cells can persist in the body and keep the virus suppressed, potentially allowing long-…

This study tests whether a same-day HPV screening and treatment approach can help prevent cervical cancer in women living with HIV in the Dominican Republic. 600 women will be randomly assigned to either the new same-day method or standard care. The goal is to see if more women c…

This study tests a new way to provide HIV care for people who have trouble keeping regular doctor appointments. It offers drop-in visits and mobile care at convenient locations like a needle exchange site. The goal is to help 400 participants in California stay in care and get th…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce food insecurity and improve insulin resistance. About 200 adults with HIV from a clinic…

This study tests whether a very low dose of semaglutide (a drug used for weight loss and diabetes) can help people with HIV avoid regaining weight after an initial weight-loss period. About 30 adults with HIV who are on stable HIV treatment and are overweight or obese will take p…

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid returning to heavy drinking. About 150 adults from a Johns Hopkins HIV clinic will take part. The goal is to see if the program helps them stay alcohol-free longer and drink le…

This study looks at how the HIV drug doravirine works in pregnant women. Researchers want to find the right dose to keep the virus under control and protect the baby. About 76 pregnant women with HIV will take either doravirine or standard HIV medication starting in the second tr…

This study tests whether using drones to deliver HIV medication to people living in remote islands of Uganda can improve viral suppression. Over 1,000 participants will either get their medication via drone or through standard methods. Researchers will compare viral load and rete…

This study tests a system that uses a special pill bottle to track when HIV medication is taken. If doses are missed, the system alerts a care team to help address problems like food or housing issues. The goal is to help 110 adults in Los Angeles stick to their HIV treatment and…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study tests a phone-based therapy called Acceptance and Commitment Therapy (ACT) to help people with HIV who drink heavily. The goal is to reduce alcohol use and improve symptoms of depression and anxiety. 300 participants will be randomly assigned to ACT or a standard brief…

This study tests a program called SAVVY that helps young people with HIV choose their preferred antiretroviral therapy (ART) and overcome barriers to getting it. The program includes counseling and a decision-support tool. Researchers will enroll 288 participants to see if this a…

This study tests two ways to help Latino men with HIV take their medication regularly. One group gets text reminders, and the other gets texts plus online support from a navigator. The goal is to see which approach works better for keeping the virus under control. 250 men will pa…

This study tests whether starting antiretroviral therapy within 7 days of an HIV diagnosis can reduce stigma and improve health outcomes for people who inject drugs. Researchers will develop a rapid-start strategy and pilot it with 135 participants at HIV clinics. The goal is to …

This study is testing a mobile health app designed to help women living with HIV remember their medications, appointments, and prescription refills. The app also addresses barriers like stigma and mistrust of the medical system. Researchers will enroll 80 women to see if the app …

This study tests a program designed specifically for Haitian immigrants living with HIV. The goal is to help them stay engaged in medical care and lower their virus levels. Participants will attend four one-on-one meetings over six months and complete questionnaires. A small grou…

This study tests whether combining an HIV vaccine with powerful antibodies can help people with HIV control the virus without daily antiretroviral therapy. 48 adults with well-controlled HIV will receive the combination and briefly stop their regular medication to see if their im…

This study looks at whether hearts from HIV-positive deceased donors are as safe and effective for HIV-positive recipients as hearts from HIV-negative donors. Fifty HIV-positive patients with advanced heart failure will receive a heart transplant, with the donor's HIV status dete…

This study tests a three-session program called We-INtervention for 160 Chinese male couples where one partner has HIV and the other does not. The program focuses on improving relationship dynamics to reduce stigma and boost well-being. Participants are randomly assigned to the p…

This pilot study tests a program where a clinical pharmacist talks with people with HIV about the risks of drinking alcohol (with or without cannabis) while taking multiple medications, especially those that affect the brain. The goal is to see if this approach can reduce falls a…

This study tests whether empagliflozin, a diabetes drug, can help people with HIV who are overweight or obese lose weight and improve metabolic health. Researchers will enroll 66 adults with HIV who are on a specific antiretroviral therapy and have a BMI over 30. Participants wil…

This study tests a program called ADELANTE for Latinos with HIV whose virus is not well-controlled. Participants will either receive five sessions with a community health worker who helps solve problems, or five reminder phone calls. The goal is to see if the health worker progra…

This study tests a support package for people with HIV in Malawi who start or restart antiretroviral therapy (ART). The package includes mobility counseling, a toll-free hotline, and multi-month medication dispensing. Researchers want to see if this approach is acceptable to pati…

This study compares two HIV medications, doravirine and dolutegravir, in people who have never taken HIV treatment before. About 610 adults with HIV-1 will receive one of these drugs along with standard medicines. The goal is to see if doravirine works just as well as dolutegravi…

This study is testing an experimental drug called CL-197 in 24 adults with HIV-1 who have never taken any anti-HIV drugs. The goal is to see if a single dose can lower the amount of virus in the blood and to check for side effects. Participants will be monitored for about two wee…

This study tests a proactive approach to help people living with HIV quit smoking. A pharmacist calls participants, offers counseling, and sends cessation medication unless they opt out. The goal is to see if this method works better than standard care. The trial involves 231 adu…

This study is testing whether a single low dose of nivolumab, a drug used in cancer immunotherapy, can reduce the latent HIV reservoir in people living with HIV who are on antiretroviral therapy (ART). The latent reservoir is a group of dormant HIV-infected cells that current tre…

This study in Malawi tests a new approach for people with HIV who have stopped taking their medication. Instead of a one-size-fits-all plan, participants can choose from different services to fit their changing needs. The goal is to see if this flexible, client-driven care helps …

This early-stage study is testing a long-acting injectable HIV prevention drug called cabotegravir, combined with an enzyme (rHuPH20) that helps the drug spread under the skin. The goal is to see if this combination is safe and how the body processes it in 214 healthy adults. Res…

This study compares two smartphone apps designed to help people living with HIV quit smoking. Participants will use one of the apps for about six months and also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, using b…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This phase 2 trial tests whether adding adalimumab (an arthritis drug) to standard tuberculosis meningitis treatment can reduce deaths in HIV-positive adults. About 130 participants in Brazil, Mozambique, and Zambia will receive adalimumab injections every two weeks for 10 weeks …

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study tests whether two experimental antibodies (MGD014 and MGD020) are safe in people with HIV who are on standard antiretroviral therapy. Some participants also receive a drug called Vorinostat to help expose hidden HIV, or temporarily stop their regular HIV meds. The goal…

This study tests whether teaching pregnant women in Kenya how to farm and providing them with supplies like seeds and irrigation pumps can reduce food shortages and improve health for both mothers and their babies. 410 pregnant women, half living with HIV, will be randomly assign…

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes better manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals…

This study looks at whether a higher dose of the TB medicine rifampicin is safe and works well in children with both HIV and TB. Twenty children will take their usual HIV and TB drugs, but for two weeks the rifampicin dose will be increased. Researchers will measure drug levels i…

This study tests a new way to help people with HIV stick to their medication. Participants join an adherence club where they pick up 6 months of medicine at once and can get peer support. The goal is to see if this approach improves viral suppression and keeps people in care comp…

This study tests whether adding the drug fostemsavir to standard HIV treatment can lower the risk of heart disease in people with well-controlled HIV. Researchers will compare heart imaging and blood tests between 150 adults who get the extra drug and those who don't. Participant…

This study tests a youth-led approach to help young people living with HIV in Kenya successfully move from pediatric to adult clinics. About 1,920 youth and their healthcare providers will take part across 32 clinics. The goal is to see if this strategy improves how many youth st…

This study tests whether trained peer recovery specialists can help Black individuals with substance use stick to their long-acting injectable HIV treatment or prevention. 186 participants will either get this peer support or standard care. The goal is to see if the peer program …

This study is testing a program called Women SHINE, which uses online peer support sessions and group therapy to help women living with HIV who have experienced interpersonal violence. The goal is to see if this approach helps them take their HIV medication more consistently and …

This study compares nurse-led treatment for drug-resistant tuberculosis (TB) in local clinics to standard doctor-led care in hospitals. About 2,944 people will take part across South Africa. The goal is to see if nurse-led care works just as well, is safe, and lowers costs for pa…

This study tests whether giving low-income Black men living with HIV a universal basic income of $500 per month for six months helps them get regular HIV care and stick with their medication. Researchers in Arkansas will compare 80 men who receive the payments to those who don't,…

This study tests whether a mobile app called Positive Peers can help young people (ages 13-34) with HIV keep the virus under control. About 250 participants who are racial, ethnic, sexual, or gender minorities will use the app and complete surveys over 12 months. The main goal is…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This study aims to help people living with HIV achieve and maintain viral suppression (low virus levels) using a smartphone-based program. It will enroll 1,000 adults who have trouble staying on treatment due to substance use, mental health issues, or other barriers. The program …

This study looks at whether kidney transplants from HIV-positive donors are safe and effective for HIV-positive recipients. Researchers will follow 30 adults with HIV and end-stage kidney disease who receive a kidney from an HIV-positive donor. The goal is to learn more about pat…

This study tests whether a two-drug HIV regimen (dolutegravir plus lamivudine) works as well as the standard three-drug regimen in people who also have tuberculosis and are on TB treatment. About 150 participants who have never taken HIV medication will be randomly assigned to on…

This study tests two remote programs—peer support groups and strengths-based case management—for adults aged 50+ living with HIV in rural Southern U.S. counties. The goal is to see if these programs help with viral suppression, medication adherence, quality of life, and depressio…

This study tests a 10-session counseling program called STEP-AD for Black women living with HIV who have a history of trauma. The goal is to help them stick to their HIV medication and achieve viral suppression. Researchers will enroll 250 participants and compare the program to …

This study is testing a group-based support program to help young sexual and gender minority people (ages 18-24) in Rio de Janeiro take their HIV medication consistently. The program includes four sessions that focus on building social support, self-confidence, and problem-solvin…

This early-stage study tests whether giving two powerful antibodies along with a therapeutic HIV vaccine can help people with HIV control the virus after they stop their daily antiretroviral therapy. The trial enrolls 48 adults in Thailand who started HIV treatment very soon afte…

This study investigates whether urine samples can be used to screen for cervical cancer in women living with HIV. Researchers will compare the accuracy of urine HPV testing with self-collected and provider-collected samples to detect cervical precancer (CIN2 or worse). The goal i…

This study compares two ways to offer cervical cancer screening to women living with HIV: standard clinic-based screening versus adding community outreach where health workers provide HPV self-collection kits at home or in community settings. About 7,600 women across multiple cli…

This study is testing a new rapid diagnostic device called TruPlex that can detect HIV, Hepatitis B, and Syphilis from a small blood sample. Researchers will enroll 1000 adults at risk for these infections to see how accurate and easy the test is to use in clinics and point-of-ca…

This study tests whether measuring HIV drugs in hair can reliably show if patients are taking their medication as prescribed. Researchers will collect hair and blood samples from 30 HIV patients who are known to be compliant. The goal is to see if hair can be a simple, non-invasi…

This study aims to see if a dried blood spot test can effectively screen drug users for hepatitis B, hepatitis C, and AIDS. Researchers will enroll 500 former or active drug users. The goal is to find a simpler way to detect these infections in a hard-to-reach population.

This study is testing a new medical device called MagIA IBC that uses a single drop of blood from a finger prick to screen for HIV, hepatitis B, and hepatitis C at the same time. Researchers will enroll 252 adults who are known or suspected to have one of these infections. The go…

This study tests a new device called MagIA H3S that can screen for HIV, hepatitis B, hepatitis C, and syphilis using a single blood sample. Researchers will enroll about 2,950 people in Ivory Coast and Kenya to see how accurate the device is compared to standard lab tests. If it …

This study checks if a new self-test for HIV and syphilis is accurate and easy for people to use at home. About 900 adults in Canada will try the test and compare results to lab tests. The study also looks at how peer support can help homeless people in Toronto get tested and tre…

This study tests whether a DNA sequencing test can help doctors choose the right antibiotics for people with drug-resistant tuberculosis (TB). Researchers will collect samples from 2,500 participants in clinics and use targeted sequencing to identify which drugs the TB bacteria a…

This study tests whether text messages about HIV prevention, sent to dental patients at community health centers, can increase HIV testing and use of preventive medications like PrEP. About 266 HIV-negative adults with at least one HIV risk factor will receive either HIV-focused …

This study looks at how well people stick to a new HIV prevention shot called lenacapavir. About 3,000 people in the U.S. who want or need HIV prevention will take part. Researchers will track who stays on the shot and how it works in everyday clinic settings.

This phase 3 trial tests MK-8527, a once-monthly oral pill, to prevent HIV-1 infection in women. About 4580 HIV-negative women will take either MK-8527 monthly or a daily PrEP pill (Truvada) to see which works better and is safer. The goal is to offer a more convenient prevention…

This large phase 3 trial is testing whether a new oral pill called MK-8527, taken just once a month, can prevent HIV infection as well as the standard daily PrEP pill. About 4,390 people at risk of HIV will be randomly assigned to receive either the monthly pill or daily Truvada …

This study tests a program called SAKHI HPV for women in India who have both HPV and HIV. The program provides support from community health workers, group sessions, and nutrition education to help women stay healthy and reduce their risk of cervical cancer. Researchers will comp…

This study tests whether a mobile app plus virtual peer support can help young men who have sex with men (ages 16–25) start and stick with PrEP, a daily pill that prevents HIV. The app provides sexual health information and connects users with a peer navigator who can guide them …

This study tests a quick digital toolkit that teaches cisgender women about PrEP, a daily pill that prevents HIV. About 125 women at clinics in Alabama and Mississippi will use the toolkit on a tablet and then talk with a healthcare worker about starting PrEP. Researchers want to…

This study tests a program called JUNTOS that helps HIV test counselors refer Latino men who have sex with men to prevention and treatment services. The goal is to see if this referral network increases the number of men who use HIV prevention or get treated. About 245 participan…

This study tests a mobile health program called WINGS+PrEP for women who have experienced heavy drinking, partner violence, and involvement with the criminal legal system. The program provides information about PrEP (a daily pill that prevents HIV) and offers support sessions. Re…

This study tests a new way to offer HIV prevention pills (PrEP) to people visiting family planning clinics in Kenya. Instead of requiring a separate appointment, HIV counselors will provide PrEP screening and prescriptions right at the family planning visit. The goal is to see if…

This study tests four different approaches to help people who inject drugs remember and stick with their daily HIV prevention pill (PrEP). Researchers will enroll 256 adults who are newly on medication for opioid use disorder and have started PrEP. The goal is to see which method…

This study in Botswana tests whether offering sexually transmitted infection (STI) testing alongside HIV prevention medication (PrEP) helps more pregnant women start and continue using PrEP. About 600 pregnant women without HIV will be split into two groups: one gets standard car…

This study is developing and testing a virtual reality tool to help young people aged 15-30 who have experienced trauma and are at risk for substance use and HIV. The goal is to see if the tool can reduce substance use and risky behaviors. Researchers are recruiting young men who…

This study tests whether a monthly injection of naltrexone can prevent fentanyl overdose in people who use stimulants like cocaine or methamphetamine but do not intentionally use opioids. One hundred participants will either receive the shot or standard harm reduction supplies. R…

This study tests a digital health program to help women involved in the criminal justice system start PrEP (a daily pill to prevent HIV) and get treatment for opioid use disorder. Researchers will compare the program to a simpler decision aid alone. The goal is to reduce stigma a…

This study tests whether giving HIV prevention pills (PrEP) to people right in the emergency room helps them start and stay on prevention. Researchers will enroll 250 HIV-negative adults at risk for HIV in Dallas. Participants get a 30-day pill supply and a clinic appointment to …

This study tests an online program called UPDOs Protective Styles to help Black women in the southeastern US learn about and start using PrEP, a medicine that prevents HIV. Researchers will recruit 1000 participants from 32 beauty salons in areas with high HIV rates. One group wi…

This study looks at whether patients and doctors in a family planning clinic find it acceptable to discuss and start PrEP, a daily pill that prevents HIV. About 83 English- or Spanish-speaking patients aged 16 and older, along with their doctors, will take part. Patients will rec…

This early-stage study is testing whether two lab-made antibodies, PGT121.414.LS and VRC07-523LS, are safe for newborns who were exposed to HIV during birth. The 48 infants will receive one or two shots of the antibodies under the skin. Researchers will monitor for side effects a…

This study combines peer navigation (trained community members) with mobile health tools to help gay, bisexual, and transgender people in rural Appalachia access HIV, STI, and hepatitis C testing and prevention services. About 141 participants will be split into two groups: one g…

This study expands on a previous mobile van HIV/STI testing program for men who have sex with men (MSM) in online spaces. Researchers will add a peer health navigator to help participants get PrEP or HIV care after testing. The study will compare this navigator approach to a refe…

This pilot study tests whether a peer-driven program can help people who inject drugs in Baltimore reduce their risk of HIV, hepatitis C, and overdose. Researchers will identify high-risk injection settings and train peers to promote safer practices, like carrying naloxone and av…

This study tests a program called CUPID that helps couples make decisions together about HIV prevention. About 1,424 women in Uganda will join with their male partners to choose and use PrEP (medicines that prevent HIV). The goal is to see if partner support increases women's use…

This study aims to make HIV prevention easier to access for underserved groups in Rio de Janeiro, such as gay and bisexual men, transgender women, and sex workers. Instead of requiring clinic visits, participants can get daily PrEP pills and support through community organization…

This study tests a smartphone app called MY-RIDE that offers just-in-time support and nurse-led sessions to help homeless youth reduce substance use and adopt HIV prevention methods like PrEP. 450 participants aged 15-24 who are homeless, use substances, and are sexually active w…

This study tests an online program called all2GETHER that teaches relationship and communication skills to gay, bisexual, and queer men, as well as transgender and non-binary people who partner with cisgender men. The goal is to see if the program can lower HIV and STI rates. 5,0…

This study tests two approaches to help men who have sex with men and use methamphetamine start or restart HIV prevention (PrEP) or treatment (ART). 400 participants will receive either contingency management (rewards for filling prescriptions) alone or combined with motivational…

This study looks at the safety of two HIV prevention methods (a long-acting shot and daily pills) in pregnant and breastfeeding women in Malawi. About 621 women who are already using or start these drugs during pregnancy will be followed along with their infants. The goal is to s…

This study in Uganda tests whether offering HIV self-testing and PrEP (a daily pill to prevent HIV) at home during routine TB contact tracing can increase HIV prevention. About 2,480 people from households with a TB patient will be randomly assigned to either home-based HIV testi…

This study looks at two strategies for getting HIV self-test kits and PrEP (a daily pill that prevents HIV) to people who might benefit. Current PrEP users will either directly give kits to friends or refer them to pick up kits. The goal is to see which method gets more people te…

This study tests a program called PrEP My Way that helps young women aged 16-24 in Kisumu, Kenya stay on HIV prevention medication. Participants can choose between a daily pill, a long-acting shot, or a vaginal ring, plus get support from peers. The goal is to see if offering cho…

This study tests a new way to prevent HIV by giving a long-acting injectable medication called lenacapavir through mobile health vans. It aims to reach 100 people in Los Angeles who are unhoused or unstably housed and face barriers to regular clinic visits. Participants receive t…

This study tests a program to help Latinx men lower their HIV risk by combining easy access to PrEP medication, social support from friends, and a national pharmacy chain. Researchers will enroll 624 men aged 18-54 and track how many start and stick with PrEP. The goal is to crea…

This study tests whether teaching Black male caregivers how to talk about sexual health can help protect Black girls aged 14-18 from HIV, other sexually transmitted infections, and sexual violence. The program involves 612 pairs of girls and their male caregivers. Researchers wil…

This study tests a program called Shamba Maisha that provides farming tools, training, and school gardens to families in Kenya. The goal is to reduce food insecurity and poverty, which are linked to higher STI and HIV risk in adolescent girls. Researchers will follow 900 girls an…

This study tests a model called STEP-UP, which partners community organizations with telehealth PrEP services to help people access HIV prevention medication. Researchers will enroll 92 participants in the Philadelphia area to see if this approach is acceptable and increases PrEP…

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12-17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience. The goal is to prevent substance …

This study tests a support service designed specifically for transgender women, men, and non-binary people in Thailand who have used chemsex drugs or other substances in the past year. The program offers HIV prevention (PrEP), mental health support, and STI care. Researchers will…

This study tests a program called CHORUS+ that helps people who inject opioids get HIV prevention medication (PrEP) and treatment for opioid use disorder (MOUD). Participants receive HIV self-testing, rapid access to medications, and 6 months of support from a peer coach. The goa…

This study tests a program called Mobile Enhanced Prevention Support (MEPS) for people recently released from jail or prison who have substance use disorders. The program pairs participants with a peer mentor, offers cash incentives for using health services, and provides a smart…

This study tests a mobile health program designed to reduce HIV-related stigma and improve use of PrEP (a daily pill that prevents HIV) among young transgender women in Thailand. The program includes counseling and stigma-reduction activities delivered via smartphone. Researchers…

This study tests whether taking the antibiotic doxycycline shortly after sex can prevent bacterial STIs like syphilis, gonorrhea, and chlamydia. It involves 200 men, transgender women, and travestis in Rio de Janeiro who are at higher risk. Participants choose whether to use doxy…

This study tests a program called TENDAI4PrEP, which uses problem-solving techniques to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program also involves their partners and healthcare providers. Researchers will enroll 132 HIV-negative pregnant …

This study in Brazil offers young men who have sex with men, transgender, and non-binary people a choice between a daily pill or a twice-yearly injection to prevent HIV. Researchers will follow 1,500 participants for up to two years to see how well each option works in real life,…

This study tests a community-based program called Moon and Sun Brothers for Latino immigrant men who have sex with men. The program includes a day-long retreat, weekly discussions, community events, and prevention counseling. Researchers want to see if it reduces risky sexual beh…

This study tests a program to help Black women in Baltimore start taking PrEP, a medication that prevents HIV. The program addresses challenges like intimate partner violence and racism that can make it hard to get PrEP. About 300 Black women who are HIV-negative and at risk will…

This study tests whether giving HIV self-testing kits and counseling to postpartum women in South Africa helps them and their male partners start PrEP (HIV prevention) or HIV treatment. About 120 women and their partners will take part. The goal is to see if this approach is feas…

This study looks at people with HIV between the ages of 65 and 74 to find those at risk for frailty—a condition that can lead to falls, hospital stays, and disability. Participants will be screened using a simple test called the Fried scale, and those at risk will receive a speci…

This study tests a decision aid that helps women in sexual and reproductive health clinics decide whether to take PrEP, a daily pill that prevents HIV. The tool will be used during counseling visits. Researchers will see if it increases PrEP use and if it's practical for clinics.…

This study is testing whether a long-acting injectable HIV prevention drug, called cabotegravir, can work for people who inject drugs. The trial will enroll 100 adults who have injected non-prescription drugs in the past 6 months and are at risk for HIV through sexual contact. Pa…

This large study in Malawi will test whether extra support—like better communication with providers, peer counselors, and earlier clinic hours—helps people at high risk for HIV stay on their prevention medication. It includes both daily pills and a new long-acting injectable. Nea…

This study tests a program that combines job-finding support with HIV prevention education for 500 young adults aged 18-24 in Baltimore who face economic hardship. Participants are randomly assigned to receive either job alerts alone or job alerts plus extra HIV prevention texts,…

This study tests whether a mobile app called MyPEEPS can reduce new HIV infections among 3,200 high-risk young men who have sex with men and non-binary individuals aged 16-29. Participants use the app to learn safer sex strategies and are compared to a standard care group. The tr…

This study is testing a new data dashboard to help clinics in Alabama track and improve how they provide PrEP, a daily pill that prevents HIV. The dashboard shows real-time data on PrEP prescriptions and patient needs, aiming to reduce racial gaps in HIV prevention. Researchers w…

This study compares two ways of offering HIV prevention medications, hepatitis C treatment, and substance use disorder care to people who inject drugs. Participants will receive services via telehealth and be followed for 12 months. The goal is to see which approach works best fo…

This study looks at how a one-time dose of two F/TAF tablets (a medicine used to prevent HIV) works in healthy adults. Researchers want to see how much of the drug gets inside cells over 14 days. 24 healthy volunteers will take the pills and have their blood tested. The goal is t…

This study tests a program in the Dallas County Jail that identifies people at high risk for HIV and offers them testing and education about PrEP, a daily pill that prevents HIV. A patient navigator helps interested individuals connect with PrEP providers after they are released.…

This study tests a peer-led program that helps women at risk of HIV choose and stick with prevention methods like PrEP. About 60 HIV-negative women in Uganda will get support from trained peers to pick what works best for them. The goal is to see if this approach increases use of…

This early-stage study tests a vaginal gel containing specially modified bacteria that produce an anti-HIV drug. The goal is to see if it is safe for healthy women and whether it can be cleared with antibiotics. If successful, this could become a long-lasting, woman-controlled HI…

This study tests a long-acting injectable PrEP (lenacapavir) program designed specifically for Latine gay, bisexual men and transgender women. Researchers want to see if offering the shots at community organizations helps more people stay on HIV prevention compared to standard cl…

This study tests a program called Treat4All that helps people who drink heavily and are at risk for HIV or already have HIV. About 160 adults from an STI clinic in Lilongwe, Malawi, will either get the program or usual care. The goal is to see if the program reduces heavy drinkin…

This study tests a program where people who use drugs (called 'Prevention Ambassadors') give HIV self-testing kits and service information to friends in their social network. The goal is to increase HIV testing and use of prevention or treatment services. About 210 participants w…

This study aims to find low-cost ways to encourage people at higher risk of HIV to get retested. Researchers will test several simple behavioral interventions, like phone messages, in 40,000 adults in Kenya and Uganda. The goal is to see which methods work best to increase repeat…

This study tests whether giving HIV prevention pills (PrEP) on a medical van is a good way to reach people who inject drugs and are at high risk for HIV. The researchers will enroll 20 adults who use drugs or are sexually active and see how many start and stay on PrEP. The goal i…

This study tests whether a health coach can help people leaving jail learn about and get PrEP, a daily pill that prevents HIV. The coach will be part of a re-entry program in Dallas. Researchers will see if this approach is feasible and acceptable to clients and staff.

This study is tracking how HIV prevention is done across 23 clinics in France, including overseas territories. Researchers will collect data on HIV testing, STI and hepatitis screening, and the use of prevention pills (PrEP) and emergency treatment (PEP). The goal is to understan…

This study is checking the long-term safety and effectiveness of a long-acting injectable drug called cabotegravir (CAB LA) for preventing HIV. It includes about 3,500 people who already received CAB LA in earlier HIV prevention studies. Participants will continue getting the sho…

This study tests a text-message program to help trans girls and nonbinary youth (ages 14-18) prevent HIV. About 200 participants will use the program on their phones. The goal is to see if it increases HIV testing and use of prevention pills (PrEP).

This study tests whether a text-messaging program can help prevent HIV in cisgender teen boys and young men (ages 13-22) who have sex with men. About 5,000 participants across the US will receive either HIV prevention texts or general healthy lifestyle texts. The goal is to see i…

This study looks at how to keep an HIV prevention program running well in Bahamian schools over several years. Researchers will test different support strategies for teachers, like regular check-ins and mentorship. About 3,705 students and teachers will take part, and the study w…

This study aims to see if training people who inject drugs to become peer educators can help their friends get tested for HIV and use prevention tools like PrEP and treatment for opioid use. About 360 participants from syringe service programs in Maryland will be recruited, along…

This study enrolls 600 adolescent girls and young women (ages 15-24) at high risk of HIV in Uganda. Participants are randomly assigned to one of three groups: HIV risk reduction sessions alone, sessions plus peer support, or sessions plus peer support and a matched savings accoun…

This early-stage study tests a new long-acting injectable drug, VH4011499, in 168 healthy adults without HIV. The goal is to see if it is safe and how the body processes it, as a potential future option for HIV prevention. Participants receive one or more doses of the drug or a p…

This study looks at whether giving HIV prevention pills (PrEP) at the same time as opioid addiction treatment in pharmacies is practical and acceptable. About 350 HIV-negative adults on opioid therapy in Alberta and Saskatchewan will take part. Researchers will track how many peo…

This study tests a peer-led community program to help Black men in Prince George's County, Maryland, start taking PrEP, a daily pill that prevents HIV. The program uses in-person events to reduce stigma, build social support, and teach skills for getting HIV care. Researchers wil…

This study is testing a new approach called PAC-Man to help prevent HIV from passing from mothers to their babies. About 2,426 mothers and infants in Malawi will take part. The goal is to see if this model helps more babies get tested for HIV early and ensures mothers receive pro…

This study will follow 5,000 HIV-negative adults in Italy who are taking PrEP, a daily pill that prevents HIV. Researchers want to see how well PrEP works in real life, how many people stick with it, and what barriers they face. The goal is to use this information to improve HIV …

This study tests whether one dose of zoledronic acid can prevent bone loss that often happens when people start HIV medications. About 110 adults newly diagnosed with HIV and showing early bone thinning will be randomly assigned to get the drug or just follow-up. Researchers will…

This study compares two drugs, pramipexole and escitalopram, to treat major depression in people with HIV. Some participants also have mild memory or thinking problems. The goal is to see which medication is safer and more effective at easing depression symptoms. About 186 adults…

This study tests two types of smell training in 80 adults aged 40+ with HIV. Participants will sniff scents at home twice a day for 8 weeks. The goal is to see if the training is easy to do and if it improves smell and thinking abilities.

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This study tests a telehealth program called MCBMAP that combines counseling and skills training to help people with HIV reduce chronic pain and unhealthy drinking. The program is delivered entirely through video calls and online materials, making it easier for participants to jo…

This pilot study tests a mobile game called Change My Story, designed to help young people (ages 16-24) living with HIV who also have depression. The game uses a choose-your-own-adventure format to teach coping skills, and is combined with problem-solving therapy. Researchers wil…

This study looks at whether hormone therapy (estrogen with or without progesterone) can safely reduce hot flashes and night sweats in women living with HIV. Researchers will also check if it improves sleep, mood, thinking, bone health, and quality of life. About 105 women aged 40…

This pilot study is testing whether chiropractic care can improve quality of life and reduce inflammation in adults with HIV. Researchers will compare a group receiving weekly chiropractic adjustments to a group receiving no treatment. The study aims to see if a larger trial is p…

This study tests a 6-month holistic behavioral health program called EASE for 200 adults with HIV or seeking HIV prevention who also use alcohol or drugs. Participants receive counseling, case management, peer support, and education. Researchers will measure changes in depression…

This study tests whether a low dose of naltrexone, a drug normally used for addiction, can safely reduce chronic nerve pain in people with HIV. About 60 adults with HIV and nerve pain will take the drug for 12 weeks and report their pain levels. The goal is to find a cheaper, non…

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines proven methods to support smoking cessation and improve HIV/TB treatment results. Researchers will enroll 86 daily…

This study tests an 8-week hybrid exercise program for people with HIV who are at risk for heart failure. Participants attend one supervised session at a center and do two unsupervised home workouts each week, plus receive education and coaching. The goal is to see if this approa…

This study compares two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which one better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25-65, have H…

This study tests a digital peer-support program to reduce HIV-related stigma in 282 adolescents aged 15–22 in Ethiopia. Participants will use a phone-based group to share experiences and support each other, aiming to improve their mental well-being and help them stay in care. The…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study tests whether an AI-powered therapy program can help older adults (50+) living with HIV who are at risk for suicide. Participants watch short videos teaching coping skills and can chat with a coach. The goal is to see if this approach is practical and helps people mana…

This study tests whether changing the injection site (buttock vs. hip) or using a virtual reality headset can lower pain from HIV medications. 120 people with HIV will each try all four combinations and rate their pain. The goal is to find a simple way to make these injections mo…

This study tests whether high-intensity interval training (HIIT) or moderate continuous exercise can improve thinking, memory, and daily function in 110 older adults with HIV who are sedentary and fatigued. Participants will exercise three times a week for four months. The goal i…

This study tests a type of brain stimulation called accelerated theta burst stimulation (a form of TMS) to see if it can lower cravings for methamphetamine in people living with HIV. Thirty adults aged 18-65 with HIV and a history of meth use will receive the treatment. The goal …

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study looks at why some people with HIV who have very low virus levels in their blood still develop thinking and memory problems. Researchers will follow 1,150 participants—including healthy volunteers—for up to 10 years, using brain scans, blood tests, and spinal fluid samp…

This early-phase study will give 9 healthy adults a single dose of the experimental HIV drug VH4524184, plus a tiny radioactive version to track it. Researchers will measure how much of the drug gets into the blood, how it's broken down, and how it leaves the body through urine a…

This study aims to understand how HIV behaves differently in the blood compared to lymph nodes and bone marrow. Researchers will take samples from 400 people living with HIV and some without HIV to measure virus levels and immune system changes. The goal is to learn more about wh…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study looks at how natural hormones and hormone therapy (like birth control or gender-affirming hormones) affect the way the HIV prevention drug cabotegravir works in the body. Researchers will measure drug levels in blood, tissues, and fluids in 32 HIV-negative adults. The …

This study investigates how depression and cannabis use together affect brain circuits involved in reward and pain in young people living with HIV. Researchers will use MRI scans and questionnaires to measure brain activity, mood, and substance use. The goal is to understand why …

This study follows a large group of people with HIV over many years to track their health, treatments, and any complications. Researchers will collect medical data during regular clinic visits to better understand how the disease and its treatments affect patients over time. The …

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study tests whether giving clinics a dedicated coach helps them offer alcohol treatment to people with HIV who drink too much. The coach provides tools and guidance to support a stepped care model, which starts with brief advice and progresses to therapy or medication if nee…

This study tests a program to help people on long-acting injectable HIV prevention (LAI-PrEP) with social needs like food, housing, and transportation. Researchers will screen participants every 4 months and connect them with community organizations for support. The goal is to se…

This study follows 700 people with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Researchers will collect blood, spinal fluid, and brain scans over time to understand how the disease progresses. No treatment is given; the goal is…

This study collects white blood cells and plasma from 400 people with HIV, including rare 'non-progressors' who control the virus without medication. Researchers will analyze immune responses and genetic markers to understand what makes these individuals special. The goal is to u…

This study reviews medical records of over 5,600 people with HIV to see how many might need special dental care due to low immune cells or blood issues. The goal is to help dentists know when to take extra steps and when standard care is safe, reducing stigma. It is an observatio…

This study in South Africa works with women who have HIV and abnormal Pap results to find out why some don't follow up for cervical cancer care. Researchers will interview patients and providers, then create a short counseling and navigation program. They will test if the program…

This study compares two sets of strategies to help HIV clinics in Cape Town, South Africa, treat depression and improve medication adherence. Ten clinics will be randomly assigned to receive either basic support or enhanced training and supervision. Researchers will track how man…

This study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understa…

This study looks at HIV that stays hidden in the body even when the virus is under control. Researchers will measure the 'latent HIV reservoir' in 130 Ugandans with HIV and compare it to similar groups in the US. Participants give blood samples and answer health questions. No new…

This study looks at people with HIV who are 75 or older and take at least five medications regularly. Researchers want to understand how this 'polypharmacy' affects healthy aging and quality of life. They will interview participants and review their medical records to count medic…

This study talks to people living with HIV from diverse backgrounds to learn what helps or hinders them from getting oral health care and cancer prevention. Researchers will hold focus groups and use questionnaires to understand barriers and gather ideas for improvement. The goal…

This study aims to understand where HIV hides in the body when people stop their daily antiretroviral therapy (ART) for a short time. Fifty adults with HIV will either stay on ART or pause it for up to 90 days. Researchers will use PET/CT scans and take small tissue samples from …

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood samples from up to 2,419 adults, both with and without HIV. Researchers will analyze these samples to compare genetic and protein differences. The goal is to better underst…

This study tracks the health of people with HIV over time to learn more about the infection and related conditions. It is for adults 18 and older in the Washington, D.C., area who have or may have HIV. Participants visit the clinic every few months for check-ups and blood tests, …

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study follows 420 adults with HIV whose virus is fully suppressed by medication. Researchers want to see if switching to a different HIV drug regimen causes hidden drug resistance to appear. They will compare people who switch drugs with those who stay on their current treat…

This study looks at how well leg muscles produce energy in older adults (60+) with and without HIV. Researchers will use MRI scans and walking tests to measure muscle metabolism and fatigue. The goal is to understand if metabolic problems in the calf muscle are linked to reduced …

This study recruits 500 people who inject drugs through social media to see if they can use at-home HIV test kits mailed to them. Participants fill out online surveys and mail back samples. The goal is to find out if this approach is a practical way to conduct HIV prevention rese…

This study collects blood plasma and white blood cells from healthy volunteers and people with HIV using a procedure called apheresis. The samples are used for laboratory research on infectious diseases and immune function. Up to 3,000 participants aged 18 and older will be enrol…

This study will screen 2,000 people with HIV for fatty liver disease using a painless ultrasound technique. The goal is to catch liver problems early and improve long-term care. Researchers will also track how different HIV medications affect liver health.

This study looks at why some people with HIV develop Immune Reconstitution Inflammatory Syndrome (IRIS) after starting HIV medications. Researchers will use PET scans and lymph node biopsies to track inflammation and immune recovery in 300 adults. The goal is to better understand…

This study looks at whether a prebiotic supplement can help repair the gut barrier and reduce inflammation in people with HIV who also have alcohol use disorder. Forty participants will take either a prebiotic or a placebo for four weeks, then switch. Researchers will measure gut…

This study collects blood and tissue samples from 200 adults with HIV and certain cancers (like Kaposi sarcoma, lymphoma, or anal cancer) to help researchers understand how HIV and cancer are connected. Participants donate samples, which are stored for future research. There is n…

This study follows 150 adults with Kaposi sarcoma (KS) for up to 10 years to learn how the disease behaves, why it comes back, and how it affects the immune system and organs. Participants will have regular check-ups, scans, and biopsies, but no new treatments are being tested. T…

This study collects white blood cells from HIV patients through a process called leukapheresis to examine how the immune system responds to early treatment. Researchers aim to enroll 60 adults—30 with early HIV and 30 with chronic HIV—who are not yet on antiretroviral therapy. Pa…

This study looks at whether inflammation in the brain causes symptoms like loss of interest and slow movement in depressed people with HIV. Sixty participants will receive either the anti-inflammatory drug baricitinib or a placebo for 10 weeks. Researchers will use brain scans an…

This observational study will follow 2,500 people aged 14–55 who are at risk for HIV across multiple countries. Researchers will track how many new HIV and other sexually transmitted infections occur over time. The goal is to gather data that could help design future studies aime…

This study looks at whether being more forgiving and holding less resentment can improve quality of life for people living with HIV. Researchers will follow 206 participants at a French hospital, measuring their tendency to forgive and their well-being. The goal is to see if forg…

This study tests a program to help people safely stop taking long-acting injectable HIV prevention (PrEP). It will enroll 30 HIV-negative adults who are considering stopping or have stopped their PrEP shots. The program includes personalized coaching and, for some, monthly drug l…

This study in Zambia will follow about 11,800 people with advanced HIV who are starting or restarting antiretroviral therapy (ART). Researchers want to learn who these patients are, what challenges they face, and how well they do in the first six months of treatment. The goal is …

This study is creating a large database of health information from 743 adults with HIV/AIDS across Brazil. Researchers will look at how common chronic diseases like heart disease, kidney disease, and cancer are in this group. The goal is to gather data to help improve health poli…

This study is testing a program to help more people in coastal Alabama get tested for HIV, quickly connect to care, and start treatment right away. The program uses data to find areas with high need, helps people link to care when diagnosed, and offers rapid antiretroviral therap…

This study follows 390 adults in Zambia with hepatitis B, some also with HIV, to see how their liver and immune system change over time. Participants join when diagnosed or starting standard antiviral treatment and are monitored for years. The goal is to learn more about the dise…

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, treatment, and prevention services. About 40 clinics will either use SAIA or continue their usual routines. The goal is to see if this approach increases the number of women a…

This study tests whether offering rapid point-of-care testing for gonorrhea and chlamydia helps more teens get HIV testing and PrEP. About 6,460 adolescents aged 16-24 will be compared: some get rapid testing, others get standard lab testing. The goal is to see if same-day result…

This study looks at whether stopping vaginal washing can lower inflammation in the cervix, which might help explain why this practice is linked to a higher risk of HIV. Researchers will measure immune cells and protective bacteria in 122 women who currently wash inside the vagina…

This study looks at the bacteria living in the lungs of people with active tuberculosis (TB) and how they change with treatment. Researchers will compare lung bacteria in diseased and healthy areas, and also check the mouth, nose, and gut. They aim to understand how these microbe…

This study collects large amounts of blood cells from people with HIV to help researchers understand why the virus persists even with treatment. It involves up to 100 participants who are either on HIV therapy, elite controllers, or untreated with detectable virus. The goal is to…

This study looks at how CBD and THC, two compounds found in cannabis, affect inflammation and brain health in people with HIV. About 90 participants will take both substances in a random order over six weeks. Researchers will measure blood markers and brain function to better und…

This study takes small samples of lymph nodes from people with HIV to learn how the virus persists even with effective medication. Researchers want to measure how much HIV remains in these tissues and how much damage has occurred. The goal is to better understand why HIV is so ha…

This study looks at how to help people with both HIV and cancer stay engaged in their HIV care while receiving cancer treatment. Researchers will first observe 150 patients to identify barriers, then develop and test strategies to improve care. A second group of 150 patients will…

This study looks at how cannabis ingredients (THC and CBD) affect decision-making, attention, and motivation in people with and without HIV. About 138 adults who use cannabis infrequently will take either THC, CBD, or a placebo for 5 days and complete thinking tests and brain flu…

This study is testing whether the antibiotic doxycycline, already used to prevent bacterial STIs after sex, also changes inflammation levels and the natural bacteria in the body. Researchers will enroll 200 men, including those with HIV and those on PrEP, and measure immune marke…

This study follows 300 young men who have sex with men (ages 18-24) living with HIV in Ho Chi Minh City, Vietnam, for 12 months. Researchers will track how well they stick to their HIV medication, their viral suppression, mental health, and quality of life. The goal is to underst…

This study looks at immune cells in the gut, spinal fluid, lymph nodes, and blood of HIV-positive and HIV-negative adults in Thailand. The goal is to understand how HIV changes the immune system in different parts of the body. About 232 people aged 18 to 50 will join. No new trea…

This study follows 100 HIV patients who were diagnosed early and started antiretroviral therapy (ART) right away. After they completed a research protocol that included a temporary stop of their HIV medications (called an analytic treatment interruption), they join this study for…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study enrolls 777 people with very early (acute) HIV infection to learn how the virus affects the body and mind. Researchers will track health events, immune responses, and behavior. No new treatment is tested; the goal is to gather knowledge for better future care.

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study looks at how harm reduction care (a non-judgmental approach to drug use) in HIV clinics affects stigma and health outcomes for people living with HIV who use drugs. Researchers will survey 768 patients and providers to understand how attitudes and care practices influe…

This study looks at whether menopause and HIV together increase heart disease risk in women. Researchers will examine inflammation and body fat using MRI scans and blood tests in 90 women with HIV. The goal is to understand why heart risks may worsen after menopause in this group…

This study tests a program called TransAction to help transgender women in Ho Chi Minh City improve their HIV prevention and care. 80 participants will either join the full program (individual sessions, group support, and social events) or just social events. The goal is to see i…

This study compares two support programs for Black men who have been in jail or prison and are at risk for or living with HIV. One group gets health navigation only; the other also gets employment help and up to $340 in incentives. Researchers want to see which approach better co…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study tests a training program for entire HIV clinics to reduce stigma and improve well-being for both patients and staff. About 1,000 people from 5 clinics in the US South will take part. The training includes interactive sessions for all staff and aims to change clinic pol…

This study is creating a large registry and biobank of 10,000 adults with various infections, such as bloodstream, heart, and bone infections. Researchers will collect medical data and biological samples to describe the infections and their treatments. The goal is to better under…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study collects blood samples from people with and without HIV to help researchers learn more about the virus. Up to 2,000 participants will donate blood for scientific studies. No treatment or medication is given as part of this study.

This study tests a method where people newly diagnosed with HIV are asked to recruit anyone they know who might benefit from HIV testing. The goal is to find more undiagnosed cases, especially among men who often avoid testing due to stigma. About 2,480 participants from 32 clini…

This study tests whether a two-day employment program can help young Black men who have sex with men stay engaged in HIV care. Researchers will ask 132 participants about their satisfaction and track changes in job-seeking confidence and sexual health visits over 13 months. The g…

This study tests whether a very brief, persuasive message—delivered by a video or a counselor—can increase HIV and hepatitis C testing among emergency room patients who initially said no. About 2,000 adults who speak English or Spanish and haven't been tested in the past year wil…

This study follows 450 HIV-positive adults in France who can naturally control the virus without taking antiretroviral drugs. Researchers want to understand how their immune systems keep the virus in check and why some eventually lose that control. The goal is to learn more about…

This 20-year study will collect information from up to 300,000 people who visit HIV and sexual health clinics in Thailand. Researchers aim to understand behaviors, social factors, and health needs to improve services. No new treatments are tested; the focus is on gathering data t…

This study follows 150 adults with advanced HIV who are hospitalized in South Africa. Researchers will interview them and review medical records to see if they successfully continue HIV care after leaving the hospital. The goal is to identify where the system fails and find ways …

This study looks at how common certain infections are among 250 asylum seekers living in reception centers in Italy. Participants must be adults who arrived in Italy between 2 and 36 months ago. The goal is to better understand infection rates to improve health screening and care…

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This study looks at how exercise training affects blood pressure and heart rate in people with HIV. Participants will do 12 weeks of supervised strength and aerobic exercises. The goal is to see if regular exercise can improve the body's muscle reflexes and exercise tolerance.

This study looks at how women with HIV in the United States decide to feed their babies, whether by breastfeeding or formula. Researchers will interview mothers and track their choices and health outcomes. The goal is to fill gaps in knowledge and create a national registry to be…

This study aims to understand frailty in people with HIV who are 50 or older. Researchers will screen participants for signs of weakness or low stamina, then offer a personalized activity plan with strength, balance, and walking goals. The study will track how well people stick w…

This study looks at whether it's practical to surgically remove a type of eye surface tumor (OSSN) in people living with HIV in Sub-Saharan Africa. About 84 participants will have the tumor cut out and be followed for a year to see if the procedure is safe and if patients return …

This study looks at 20 adults in Ethiopia who have both HIV and visceral leishmaniasis (a serious parasitic disease). Researchers want to find out why the parasite keeps coming back in some patients and how to better monitor treatment. Participants provide samples and attend foll…

This study in Uganda tests whether trained peer counselors can help people with tuberculosis (TB) and HIV stay on track with their medications. About 1,920 adults will take part, and researchers will compare treatment success rates between clinics using peer-led education and tho…

This study looks at whether long-acting antiretroviral drugs for HIV prevention (PrEP) are effective and affordable for key populations in Thailand, including men who have sex with men and transgender women. Researchers will survey over 10,000 people about their preferences, anal…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study looks at whether traditional healers in rural Uganda can offer HIV screening tests to children aged 18 months to 5 years. Researchers will compare how many caregivers accept testing from a healer versus how many follow a referral to a health center. The goal is to find…

This study is testing whether setting up special HIV teams in hospitals can increase testing for undiagnosed HIV. The teams will remind doctors to test patients with certain health conditions, reduce stigma, and improve care links. Over 5,200 patients across ten European countrie…

This study looks at whether text messages can encourage teenagers (ages 13-19) to get tested for HIV. About 360 teens who have had sex and are HIV-negative or don't know their status will receive either helpful texts or general information. Researchers will check if more teens ge…

This study is testing whether giving the COVID-19 booster and flu vaccine at the same time is as good as giving them a month apart for people with weakened immune systems. It also compares getting a COVID-19 booster every 3 months versus every 6 months. The trial involves 660 adu…

This study is testing whether people with HIV can collect small blood samples at home using a finger prick or a simple device. The goal is to see if these home-collected samples are as good as clinic-drawn blood for measuring levels of HIV medications. About 150 adults already on…

This study looks at how the drug bulevirtide changes gut bacteria and bile acids in people with hepatitis delta (a serious liver infection). Researchers will follow 20 patients for 48 weeks, collecting stool and blood samples to see how these changes relate to liver health. The g…

This study looks at whether getting legal help can improve HIV care for people who have been in jail. Researchers will work with 100 adults living with HIV who have a detectable viral load and a history of incarceration. They will also train healthcare providers on how to connect…

This study is a long-term project that collects health information from 30,000 HIV patients at 15 clinics in France. The goal is to track how well HIV treatments are working, monitor changes in the disease over time, and understand related health issues like hepatitis C. No new t…

This study is gathering information from 2,500 adults with HIV who are having their first upper digestive tract endoscopy. Researchers will record patient details, test results, and any diagnoses found during the procedure. The goal is to better understand digestive health issues…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study compares fat storage around the heart and liver in people with HIV versus the general population using MRI scans. Researchers aim to understand why HIV-positive individuals have double the risk of heart attacks. The study involves 100 participants aged 40 and older wit…

This study looks at how adults in France choose to get tested for HIV voluntarily. Researchers will survey 1,000 people aged 18 and older to see which testing methods they use, such as doctor prescriptions, free testing centers, or self-tests. The goal is to learn more about test…

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at how damage to the vagus nerve may cause gut issues and inflammation in people with HIV. Researchers will test two approaches—a drug called pyridostigmine and non-invasive vagus nerve stimulation—to see if they can improve gut function and reduce inflammation. …

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This pilot study tests whether telemedicine can help people living with HIV in Alabama who also struggle with opioid or stimulant misuse get follow-up care. Thirty participants will receive either telemedicine or standard care. The goal is to see if telemedicine is feasible and a…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study tests whether a specially designed play can help reduce stigma around PrEP (pills that prevent HIV) for young women in Kenya. About 160 people, including young women who use PrEP and community members, will watch the play and share their thoughts. The goal is to see if…

This study looks at better ways to provide cervical cancer screening and treatment to women living with HIV in Nigeria. About 2,400 women will take part. Researchers will compare two sets of strategies to see which works best for getting women screened and treated. The goal is to…

This study looks at how a type of talk therapy for depression changes the gut microbiome, immune system, and brain function in people living with HIV. Researchers will enroll 150 adults with HIV and depression to understand these connections. The goal is to learn more about how t…

This long-term study follows 19,000 people with or at risk for HIV in Washington, DC to track their health outcomes and quality of care. Researchers will monitor viral suppression rates and new infections over up to 10 years. The goal is to find ways to improve HIV treatment and …

This study tests whether giving syringe service programs funding and training helps them offer routine HIV and hepatitis C testing to people who inject drugs. About 40 programs will either get this support or just receive a link to CDC resources. The goal is to see if more people…

This study follows 380 children in Uganda for two years to understand how malaria and HIV treatments interact. Half the children have HIV and half do not. Researchers will measure changes in body weight, blood sugar, and drug levels to find the best ways to treat both infections …

This study will offer HIV tests to everyone visiting emergency departments in South Africa and Baltimore, regardless of risk factors. The goal is to find undiagnosed HIV cases and connect people to either treatment or preventive medication (PrEP). Researchers will track how many …

This study pauses HIV medication in 40 volunteers to closely monitor how the virus and body interact during the earliest stages of rebound. Participants stop their antiretroviral therapy and undergo frequent testing, resuming treatment within three weeks. The goal is to learn mor…

This study looks at whether peer education and support can help more adolescents and young adults (ages 15-39) living with HIV get screened for cancer and stick with their cancer treatment. Researchers will work with 4,100 participants in Zambia to improve early diagnosis and tre…

This study looks at whether people with HIV have chronic pain because their bodies don't make enough natural painkillers (opioid peptides). Researchers will test pain sensitivity in 200 adults (with and without HIV) using heat, touch, and pressure. The goal is to understand the c…

This study looks at how medical care affects the quality of life of 100 pregnant women living with HIV. Researchers will ask women to fill out questionnaires about their feelings and experiences during pregnancy and one year after giving birth. The goal is to improve care and sup…

This study looks back at medical records of 50 adults in France who were diagnosed with HIV between 2021 and 2024. Researchers want to find out if doctors missed signs of HIV during visits in the year before diagnosis. The goal is to understand why testing is delayed and help cat…

This study looks at how HIV affects a natural cell cleanup process called autophagy in people with HIV. Researchers will compare blood cells from 180 participants, including those on HIV medication, rare controllers, and healthy volunteers. The goal is to understand why cell clea…

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will follow about 6,770 participants, including those with HIV, and use advanced genetic testing to track TB spread among close contacts. The goal is…

This study looks at how to get more people in Canadian federal prisons to use needle exchange programs, which can help stop the spread of HIV and hepatitis C. Researchers will work in nine prisons, including five women's prisons, to find out what helps or hinders program use and …

This study tests whether having traditional healers offer HIV counseling and testing can increase the number of people who get tested compared to usual care. Over 230,000 adults in rural South Africa will take part. The goal is to reach people who might avoid regular clinics and …

This study looks at 400 women living with HIV to understand how the bacteria in their gut and vagina might influence HPV infection and cervical changes. Researchers will collect samples to see if an imbalance in vaginal bacteria makes these women more likely to get HPV and develo…

This study looks at whether people living with HIV can collect their own anal swab to test for HPV (a virus that can cause anal cancer) as accurately as a doctor can. About 400 adults aged 30 and older in Reunion Island will try both methods and share which they prefer. The goal …

This study looks at two ways to screen for cervical cancer in women with HIV in Cameroon. One way sends self-collected samples to a central lab; the other uses a mobile team that tests and treats on the spot. Researchers want to see which approach helps more women complete all sc…

This study will analyze medical records from up to 1 million people in Malawi to understand how different models of HIV treatment delivery are working. The goal is to see which approaches are most effective and efficient, without directly interacting with patients. Findings could…

This pilot study tests whether pasteurized donor human milk (PDHM) is a practical feeding option for infants born to mothers living with HIV. Ten families in Saskatchewan will try PDHM as a supplement to breastfeeding or formula, and researchers will track how often it's used and…

Researchers are analyzing medical records from about 7 million people with HIV in South Africa to see how different models of care are working. The goal is to understand which approaches help more people stay on treatment and achieve viral suppression. No new drugs or treatments …

This study looks at medical records from 1.2 million people with HIV in Zambia to understand how different models of delivering HIV treatment are working. Researchers want to see how many people are using these models, how well they control the virus, and what the costs are. No n…

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This study looks at whether giving out special syringes with less leftover space (low dead-space) can help reduce the spread of HIV and hepatitis among people who inject drugs. Researchers will talk with participants and track their health in several countries. The goal is to fin…

This study follows 120 people with HIV who switch to a long-acting injectable treatment or stay on oral pills. Researchers will measure HIV reservoirs, immune activation, and gut bacteria changes over a year. The goal is to see if injectable therapy reduces inflammation and hidde…

This study looks at the gut bacteria of 132 people with HIV who are 55 or older and have had the virus under control for at least 5 years. Researchers want to see if changes in gut bacteria over time are linked to signs of frailty and other health problems. The goal is to better …

This study tests whether a single-visit approach to cervical cancer screening and treatment can reduce dropout rates among women living with HIV in Cameroon. Researchers will compare the current multi-visit system with a streamlined process that includes HPV testing and same-day …