Silent spreaders? study probes asymptomatic TB transmission

NCT ID NCT07312266

Recruiting now Knowledge-focused Sponsor: Barcelona Institute for Global Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will follow about 6,770 participants, including those with HIV, and use advanced genetic testing to track TB spread among close contacts. The goal is to better understand how asymptomatic TB contributes to the epidemic.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could show that asymptomatic TB plays a key role in spreading the disease, potentially reshaping how we control TB outbreaks.
What could go wrong: This is an observational study, not a treatment trial. It may not prove direct transmission, and results might not apply to all populations or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

active tuberculosis AIDS HIV infectious disease latent tuberculosis infection tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV HIV (HUMAN IMMUNODEFICIENCY VIRUS) TUBERCULOSIS TUBERCULOSIS (TB)

Contacts and locations

Locations

Centro de Investigação em Saúde de Manhiça (CISM)
RECRUITING

Manhiça, Maputo Province, Mozambique

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